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The map label for this gene is argE

Identifier: 157158301

GI number: 157158301

Start: 4487762

End: 4488913

Strand: Reverse

Name: argE

Synonym: EcE24377A_4496

Alternate gene names: 157158301

Gene position: 4488913-4487762 (Counterclockwise)

Preceding gene: 157158861

Following gene: 157159345

Centisome position: 90.15

GC content: 51.48

Gene sequence:

>1152_bases
ATGAAAAACAAATTACCGCCATTTATCGAGATTTACCGTGCTCTGATTGCCACACCTTCAATAAGCGCCACGGAAGAGGC
ACTCGATCAAAGCAATGCAGATTTAATCACTCTGCTGGCGGACTGGTTTAAAGATTTAGGCTTCAATGTGGAAGTGCAGC
CTGTGCCAGGAACTCGCAACAAATTTAATATGCTGGCCAGTTGCGGACAGGGGGCTGGCGGCTTGTTGCTGGCGGGGCAT
ACCGATACGGTACCATTTGATGACGGTCGCTGGACGCGTGATCCGTTTACACTGACGGAGCATGACGGCAAGCTTTACGG
CTTAGGCACCGCCGACATGAAAGGCTTTTTTGCGTTTATCCTTGATGCGCTACGCGATGTCGACGTCACGAAACTGAAAA
AACCGCTCTACATTCTGGCGACTGCTGATGAAGAAACCAGTATGGCCGGAGCGCGTTATTTTGCCGAAACTACCGCCCTG
CGCCCGGATTGCGCCATCATTGGCGAACCGACGTCACTACAACCGGTACGCGCACATAAAGGTCATATCTCTAACGCCAT
CCGTATTCAGGGCCAGTCGGGGCACTCCAGCGATCCAGCACGCGGAGTTAACGCTATCGAACTAATGCACGACGCCATCG
GGCATATTTTGCAATTGCGCGATAACCTGAAAGAACGTTATCACTACGAAGCGTTTACCGTGCCATACCCTACGCTCAAC
CTCGGGCATATTCACGGTGGCGACGCTTCTAACCGTATTTGCGCTTGCTGTGAGTTGCATATGGATATTCGTCCGCTGCC
TGGCATGACACTCAATGAACTTAATGGTTTGCTCAACGATGCATTGGCTCCGGTGAACGAACGCTGGCCGGGTCGTCTGA
CGGTCGACGAGCTGCATCCGCCGATCCCTGGCTATGAATGCCCACCGAATCATCAACTGGTTGAAGTGGTTGAGAAATTG
CTCGGAGCAAAAACCGAAGTGGTGAACTACTGTACCGAAGCGCCGTTTATTCAAACGTTATGCCCGACGCTGGTGTTGGG
GCCTGGCTCAATTAATCAGGCTCATCAACCTGATGAATATCTGGAAACACGGTTTATCAAGCCCACCCGCGAACTGATAA
CCCAGGTAATTCACCATTTTTGCTGGCATTAA

Upstream 100 bases:

>100_bases
CCTTACGGCTGGTGGGTTTTATTACGCTCAACGTTAGTGTATTTTTATTCATAAATACTGCATGAATATTGATACTATCA
TGACCAGAGGTGTGTCAACA

Downstream 100 bases:

>100_bases
AACGTAGGCCGGATAAGGCGCTCGCGCCGCATCCGGCACTGTTGTCAAACTCCAGTGCCGCAATAATGTCGGATGCGATA
CTTGCGCATCTTATCCGACC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGH
TDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTAL
RPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLN
LGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVNERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKL
LGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH

Sequences:

>Translated_383_residues
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGH
TDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTAL
RPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLN
LGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVNERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKL
LGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH
>Mature_383_residues
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGH
TDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTAL
RPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLN
LGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVNERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKL
LGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=383, Percent_Identity=99.4778067885117, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1789236, Length=373, Percent_Identity=26.5415549597855, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788816, Length=259, Percent_Identity=28.957528957529, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551016, Length=384, Percent_Identity=25.2604166666667, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_ECO24 (A7ZUH5)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001465454.1
- ProteinModelPortal:   A7ZUH5
- SMR:   A7ZUH5
- STRING:   A7ZUH5
- EnsemblBacteria:   EBESCT00000019215
- GeneID:   5588158
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_4496
- NMPDR:   fig|331111.3.peg.2110
- eggNOG:   COG0624
- GeneTree:   EBGT00050000009680
- HOGENOM:   HBG728841
- OMA:   RICGQCA
- ProtClustDB:   PRK05111
- BioCyc:   ECOL331111:ECE24377A_4496-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 42365; Mature: 42365

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 82-82 ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRN
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
KFNMLASCGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFI
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHH
LDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHK
HHHHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHC
GHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLN
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCE
LGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVNERWPGRLTVDELHP
ECCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCC
PIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEY
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCHHH
LETRFIKPTRELITQVIHHFCWH
HHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRN
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
KFNMLASCGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFI
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHH
LDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHK
HHHHHCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHC
GHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLN
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCE
LGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVNERWPGRLTVDELHP
ECCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCC
PIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEY
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCHHH
LETRFIKPTRELITQVIHHFCWH
HHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA