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The map label for this gene is torZ [H]

Identifier: 157157392

GI number: 157157392

Start: 2082175

End: 2084622

Strand: Reverse

Name: torZ [H]

Synonym: EcE24377A_2103

Alternate gene names: 157157392

Gene position: 2084622-2082175 (Counterclockwise)

Preceding gene: 157156650

Following gene: 157157865

Centisome position: 41.86

GC content: 51.43

Gene sequence:

>2448_bases
TTGATCAGGGAGGAAGTTATGACATTAACAAGACGTGAATTTATTAAACACAGCGGTATTGCCGCTGGGGCGCTGGTGGT
GACATCGGCAGCACCGCTACCCGCATGGGCAGAAGAGAAGGGCGGTAAAATCCTCACCGCGGGCCGTTGGGGAGCGATGA
GCGTAGAAGTGAAGGACGGCAAGATTGTTTCTTCGACAGGCGCGCTGGCGAAAACCATACCGAACTCCTTACAGTCTACG
GCGGCGGATCAGGTACACACCACGGCACGTATTCAGCATCCGATGGTAAGAAAAAGCTATCTCGATAATCCACTGCAACC
GGCGAAAGGTCGTGGCGAAGATACTTATGTACAGGTGAGCTGGGAGCAAGCATTAAAACTGATTCATGAGCAACACGATC
GCATTCGCAAAGCTAACGGACCATCTGCTATTTTTGCCGGATCATACGGCTGGCGCTCTTCTGGCGTGTTGCATAAAGCG
CAAACCTTACTGCAACGTTATATGAACCTGGCGGGCGGTTATTCCGGGCATAGCGGCGATTATTCAACCGGGGCGGCACA
GGTGATCATGCCGCATGTGGTCGGTTCTGTAGAGGTGTATGAACAGCAGACCTCCTGGCCGCTGATTCTGGAAAACAGCC
AGGTTGTGGTGCTGTGGGGAATGAACCCGCTGAATACCTTAAAAATTGCCTGGAGCAGTACCGATGAGCAAGGGCTGGAA
TACTTCCATCAGCTGAAAAAATCTGGCAAACCAGTGATTGCCATTGATCCTATCCGCTCCGAAACCATCGACTTCTTTGG
CGATAATGCCACCTGGATCGCGCCGAATATGGGCACCGACGTGGCACTGATGTTAGGGATTGCGCATACCCTGATGACAC
AAGGCAAACATGATAAAGTGTTCCTTGAAAAATACACCACCGGGTATCCGCAGTTTGAAGAGTATCTGACAGGTAAGAGC
GATAATACGCCGAAGAGCGCGGCCTGGGCGGCGGAAATTACTGGCGTACCGGAAGCGCAGATAGTCAAACTCGCTGAACT
GATGGCGGCGAATCGCACAATGCTGATGGCAGGCTGGGGAATTCAGCGCCAGCAATATGGTGAACAGAAACACTGGATGC
TGGTGACGCTGGCGGCGATGTTAGGGCAGATTGGTACACCGGGCGGCGGTTTTGGTTTCTCTTATCATTACTCCAATGGT
GGCAACCCGACGCGTGTTGGCGGCGTGCTGCCGGAAATGTCTGCGGCGATTGCCGGACAGGCCAGCGAGGCCGCTGATGA
TGGCGGAATGACGGCGATTACTGTTGCCCGTATCGTCGATGCGCTGGAAAATCCTGGTGGCAAATATCAGCATAACGGTA
AAGAACAAACGTATCCGAATATCAAAATGATCTGGTGGGCGGGTGGCGGTAACTTTACCCATCACCAGGATACTAATCGT
CTGATTAAAGCATGGCAGAAACCGGAGATGATCGTCGTTTCTGAATGCTACTGGACCGCAGCTGCTAAACATGCAGATAT
CGTATTACCGATCACCACATCGTTTGAGCGCAATGACTTGACGATGACCGGTGATTACAGCAACCAGCATATTGTGCCGA
TGAAGCAGGCTGTTGCTCCGCAATTTGAAGCGCGAAACGATTTTGATGTGTTTGCCGATCTTGCGGAATTACTCAAACCT
GGCGGAAAAGAGATCTATACCGAAGGTAAAGATGAAATGGCGTGGCTGAAATTTTTCTATGATGCCGCTCAGAAAGGGGC
CCGTGCGCAACGCGTCACTATGCCAATGTTTAATGTCTTCTGGCAGCAAAATAAACTGATCGAAATGCGCCGCAGCGAGA
AGAACGAACAGTACGTTCGTTATGGTGATTTCCGCGCCGATCCGGTGAAAAATGCGCTGGGTACGCCAAGTGGCAAAATT
GAGATTTACTCCAAAACGCTGGAAAAATTTGGCTATAAGGATTGCCCGGCACACCCAACCTGGCTTGCGCCTGATGAGTG
GAAGGGTACCGCCGACGAGAAGCAGTTGCAGCTTCTGACCGCACATCCGGCACACCGTTTACACAGTCAGCTTAACTATG
CGGAACTGCGTAAAAAATATGCGGTTGCCGATCGTGAACCGATCACTATTCACACCGAAGATGCTGCTCGATTTGGTATT
GCGAATGGCGATCTGGTGCGTGTCTGGAACAAACGTGGTCAGATACTAACAGGTGCGGTGGTGACTGACGGGATCAAAAA
AGGCGTGGTATGCGTGCATGAAGGTGCATGGCCAGATCTGGAAAATGGCTTATGTAAAAACGGCAGTGCGAACGTGTTAA
CGGCGGATATCCCCAGCTCGCAGCTGGCAAATGCCTGTGCCGGTAACTCTGCGCTGGTGTATATCGAAAAATATACGGGT
AACGCACCGAAGTTAACGGCATTTGATAAGCCTGCTGTTCAGGCGTAA

Upstream 100 bases:

>100_bases
AATGGGTGCGCGAACCAGCATGAGCGAAAACGAACTGGACATTTTGACGCGGTACTTCCAGTACAACGCCAAAGATATTA
CCGAGAAACAGTGATCCTCG

Downstream 100 bases:

>100_bases
GAAGTGAATAGCGCCCGGAAACGGGCGCTGAGGTTATGCAAACGTAAAACTGCCTGATGCGCTATGCTTATCAGGCCTAC
ATAGTCCCTGCAATAGATTG

Product: trimethylamine N-oxide reductase III, subunit TorZ

Products: NA

Alternate protein names: TMAO reductase 2; Trimethylamine oxidase 2 [H]

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MIREEVMTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQST
AADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHDRIRKANGPSAIFAGSYGWRSSGVLHKA
QTLLQRYMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLE
YFHQLKKSGKPVIAIDPIRSETIDFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKS
DNTPKSAAWAAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNG
GNPTRVGGVLPEMSAAIAGQASEAADDGGMTAITVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNR
LIKAWQKPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKP
GGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNVFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKI
EIYSKTLEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGI
ANGDLVRVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTG
NAPKLTAFDKPAVQA

Sequences:

>Translated_815_residues
MIREEVMTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQST
AADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHDRIRKANGPSAIFAGSYGWRSSGVLHKA
QTLLQRYMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLE
YFHQLKKSGKPVIAIDPIRSETIDFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKS
DNTPKSAAWAAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNG
GNPTRVGGVLPEMSAAIAGQASEAADDGGMTAITVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNR
LIKAWQKPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKP
GGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNVFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKI
EIYSKTLEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGI
ANGDLVRVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTG
NAPKLTAFDKPAVQA
>Mature_815_residues
MIREEVMTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQST
AADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHDRIRKANGPSAIFAGSYGWRSSGVLHKA
QTLLQRYMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLE
YFHQLKKSGKPVIAIDPIRSETIDFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKS
DNTPKSAAWAAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNG
GNPTRVGGVLPEMSAAIAGQASEAADDGGMTAITVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNR
LIKAWQKPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKP
GGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNVFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKI
EIYSKTLEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGI
ANGDLVRVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQLANACAGNSALVYIEKYTG
NAPKLTAFDKPAVQA

Specific function: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=809, Percent_Identity=98.7639060568603, Blast_Score=1664, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=773, Percent_Identity=63.9068564036222, Blast_Score=1063, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=786, Percent_Identity=45.29262086514, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=31.25, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1787870, Length=853, Percent_Identity=28.8393903868699, Blast_Score=272, Evalue=7e-74,
Organism=Escherichia coli, GI171474008, Length=847, Percent_Identity=28.9256198347107, Blast_Score=240, Evalue=3e-64,
Organism=Escherichia coli, GI3868721, Length=714, Percent_Identity=23.3893557422969, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.7.2.3 [H]

Molecular weight: Translated: 89624; Mature: 89624

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIREEVMTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDG
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCC
KIVSSTGALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVS
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEE
WEQALKLIHEQHDRIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGD
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
YSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLE
CCCCHHHHHHHHHHCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHH
YFHQLKKSGKPVIAIDPIRSETIDFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKV
HHHHHHHCCCCEEEECCCCCCHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
FLEKYTTGYPQFEEYLTGKSDNTPKSAAWAAEITGVPEAQIVKLAELMAANRTMLMAGWG
EEEHHCCCCCCHHHHHCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHCCCEEEEECCC
IQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQ
CCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCC
ASEAADDGGMTAITVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
LIKAWQKPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAP
HHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCC
QFEARNDFDVFADLAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNVF
CCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHH
WQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPT
HCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCC
WLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGI
CCCCCCCCCCCCHHHEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCHHHCCC
ANGDLVRVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSS
CCCCEEEEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCHH
QLANACAGNSALVYIEKYTGNAPKLTAFDKPAVQA
HHHHHHCCCCEEEEEEECCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MIREEVMTLTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDG
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCC
KIVSSTGALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVS
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEE
WEQALKLIHEQHDRIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGD
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
YSTGAAQVIMPHVVGSVEVYEQQTSWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLE
CCCCHHHHHHHHHHCCEEEEECCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHH
YFHQLKKSGKPVIAIDPIRSETIDFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKV
HHHHHHHCCCCEEEECCCCCCHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEE
FLEKYTTGYPQFEEYLTGKSDNTPKSAAWAAEITGVPEAQIVKLAELMAANRTMLMAGWG
EEEHHCCCCCCHHHHHCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHCCCEEEEECCC
IQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQ
CCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCC
ASEAADDGGMTAITVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
LIKAWQKPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAP
HHHHHCCCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCC
QFEARNDFDVFADLAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNVF
CCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHH
WQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPT
HCCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCC
WLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGI
CCCCCCCCCCCCHHHEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCHHHCCC
ANGDLVRVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSS
CCCCEEEEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCHH
QLANACAGNSALVYIEKYTGNAPKLTAFDKPAVQA
HHHHHHCCCCEEEEEEECCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]