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The map label for this gene is nanC [H]

Identifier: 157155937

GI number: 157155937

Start: 4901014

End: 4901730

Strand: Reverse

Name: nanC [H]

Synonym: EcE24377A_4910

Alternate gene names: 157155937

Gene position: 4901730-4901014 (Counterclockwise)

Preceding gene: 157156560

Following gene: 157158030

Centisome position: 98.44

GC content: 42.54

Gene sequence:

>717_bases
ATGAAAAAGGTTAAAATACTTTCTGGCGTATTATTACTGTGCTTTTCGTCACCATTAATTTCTCAGGCTGCGACACTGGA
CGTACGTGGTGGATATCGTAGTGGAAGCCACGCCTATGAGACTCGACTCAAAGTCAGTGAGGGATGGCAAAATGGATGGT
GGGCAAGTATGGAAAGTAATACCTGGAATACCATTCATGATAATAAAAAGGAAAATGCCGCACTCAATGATGTTCAGGTT
GAAGTTAATTACGCGATTAAACTTGATGATCAATGGACGGTGCGCCCGGGAATGTTAACGCATTTTAGCAGCAACGGCAC
ACGCTACGGACTCTACGTAAAACTGTCCTGGGACGCGACAAAAGATCTTAATTTTGGCATTCGCTATCGTTACGACTGGA
AAGCTTACCGACAACAAGACTTATCCGGTGATATGTCTCGTGATAACGTTCATCGTTGGGATGGATATGTCACTTACCAT
ATTAATAGTGATTTCACCTTCGCATGGCAAACGACGCTATACAGCAAACAGAACGATTATCGCTATGCAAACCATAAGAA
ATGGGCGACGGAAAATGCATTTGTTCTACAATACCATATGACGCCCGATATTACGCCATACATAGAATATGACTACCTGG
ACCGTCAGGGTGTTTACAACGGCAGAGATAATTTATCGGAAAACAGTTATCGCATTGGTGTGTCATTTAAACTGTAG

Upstream 100 bases:

>100_bases
AGACACTATAAGCCTGGCAAAAAAATATTACACAACATAAATGCTAATTGTTTATGCGGGCTTTGTATTGCTTTCTGTAT
CCTACAAATGAGTGAAATTT

Downstream 100 bases:

>100_bases
TAGACAGGAGACAGTCACAATGAATAAAACAATAACGGCGCTTGCTATCATAATGGCTTCATTTGCCGCAAACGCGTCTG
TATTACCGGAAACTCCTGTG

Product: oligogalacturonate-specific porin protein (KdgM)

Products: NA

Alternate protein names: Porin nanC [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKKVKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESNTWNTIHDNKKENAALNDVQV
EVNYAIKLDDQWTVRPGMLTHFSSNGTRYGLYVKLSWDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYH
INSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL

Sequences:

>Translated_238_residues
MKKVKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESNTWNTIHDNKKENAALNDVQV
EVNYAIKLDDQWTVRPGMLTHFSSNGTRYGLYVKLSWDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYH
INSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
>Mature_238_residues
MKKVKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESNTWNTIHDNKKENAALNDVQV
EVNYAIKLDDQWTVRPGMLTHFSSNGTRYGLYVKLSWDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYH
INSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL

Specific function: Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac or sialic acid) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oligogalacturonate-specific porin kdgM (TC 1.B.35) family. NanC subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082420, Length=238, Percent_Identity=99.1596638655462, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1790307, Length=239, Percent_Identity=25.1046025104602, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009331
- InterPro:   IPR001702 [H]

Pfam domain/function: PF06178 KdgM [H]

EC number: NA

Molecular weight: Translated: 27932; Mature: 27932

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN
CCCCHHHHHHHHHHHCCCHHCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCC
TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGLYVKLSWDAT
CCCCCCCCCCCCCEEEEEEEEEEEEEEECCCEEECCCEEEEECCCCEEEEEEEEEECCCC
KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY
CCCCCCEEEEECHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCEEEEEEEEEECCCCCC
RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MKKVKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN
CCCCHHHHHHHHHHHCCCHHCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCC
TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGLYVKLSWDAT
CCCCCCCCCCCCCEEEEEEEEEEEEEEECCCEEECCCEEEEECCCCEEEEEEEEEECCCC
KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY
CCCCCCEEEEECHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCEEEEEEEEEECCCCCC
RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]