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The map label for this gene is uhpC [H]

Identifier: 157155233

GI number: 157155233

Start: 4163927

End: 4165246

Strand: Reverse

Name: uhpC [H]

Synonym: EcE24377A_4175

Alternate gene names: 157155233

Gene position: 4165246-4163927 (Counterclockwise)

Preceding gene: 157156876

Following gene: 157159158

Centisome position: 83.65

GC content: 54.85

Gene sequence:

>1320_bases
ATGTTGCCGTTTCTGAAAGCGCCTGCCGATGCGCCATTAATGACTGATAAATATGAAATTGATGCCCGCTATCGCTACTG
GCGTCGGCATATTCTGCTGACCATCTGGCTGGGTTATGCGCTGTTTTACTTCACGCGGAAAAGTTTTAACGCCGCCGTAC
CAGAAATCCTTGCTAACGGCGTGCTCAGCCGTAGCGATATCGGCCTGTTAGCGACCCTGTTTTACATTACCTATGGCGTG
TCGAAGTTTGTCTCCGGCATTGTCAGCGATCGCTCAAATGCCCGTTATTTTATGGGGATAGGGCTTATCGCCACGGGCAT
TATCAACATTCTGTTTGGCTTCTCGACGTCGCTATGGGCGTTTGCCGTGCTCTGGGTGCTGAACGCCTTTTTCCAGGGCT
GGGGTTCACCGGTGTGTGCGCGTCTGTTAACGGCCTGGTATTCACGTACCGAGCGCGGCGGTTGGTGGGCATTATGGAAC
ACGGCGCATAACGTCGGCGACGCACTCATTCCCATTGTGATGGCAGCGGCTGCGCTGCATTACGGCTGGCGTGCCGGGAT
GATGATTGCTGGTTGTATGGCGATAGTCGTGGGGATTTTTCTCTGCTGGCGGCTACGCGATCGCCCGCAGGCGTTAGGTT
TACCGGCGGTCGGTGAATGGCGACACGACGCGCTGGAAATTGCTCAACAACAAGAAGGGGCAGGGTTGACGCGTAAAGAG
ATCCTCACCAAATATGTGTTGCTGAATCCGTATATCTGGCTGCTTTCGTTTTGCTATGTGCTGGTCTATGTGGTCCGGGC
GGCGATCAACGACTGGGGCAATTTGTATATGTCCGAGACACTGGGCGTCGATCTGGTCACGGCGAATACGGCAGTGACGA
TGTTTGAACTGGGCGGATTTATCGGTGCGCTGGTAGCCGGTTGGGGCTCGGACAAATTGTTTAACGGCAACCGAGGGCCG
ATGAATTTGATTTTCGCCGCCGGAATTTTGCTTTCAGTCGGCTCCCTGTGGCTGATGCCATTTGCCAGCTACGTGATGCA
GGCAACCTGCTTCTTCACCATTGGTTTTTTTGTCTTTGGCCCACAGATGTTAATCGGTATGGCGGCGGCAGAGTGTTCCC
ACAAAGAGGCGGCAGGGGCGGCGACGGGGTTTGTCGGCTTGTTTGCTTATCTGGGGGCGTCGCTTGCTGGTTGGCCGCTG
GCGAAAGTACTCGATACCTGGCACTGGAGCGGATTTTTTGTGGTTATCTCTATCGCCGCCGGGATTTCCGCACTGCTGTT
ACTGCCCTTTTTGAACGCCCAGACACCGCGCGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAGCGCGTAACGGCGCTGGGTGGCACATTACACATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAAC
GCTATGTCTAAGGTTTGATG

Downstream 100 bases:

>100_bases
TGCATCTCACCTTTTCACTTCATATCCGGCAAAACTAAGAAATTTTCCAGGTTTTGCCTGGACGCTATCTCAGGCCTGAT
TTGCTGCTGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGDALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA

Sequences:

>Translated_439_residues
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGDALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA
>Mature_439_residues
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGDALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=436, Percent_Identity=29.8165137614679, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4503847, Length=436, Percent_Identity=29.8165137614679, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI256219483, Length=436, Percent_Identity=29.8165137614679, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI256219543, Length=450, Percent_Identity=29.3333333333333, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI256219564, Length=366, Percent_Identity=27.5956284153005, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI46361976, Length=390, Percent_Identity=22.5641025641026, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI14150047, Length=291, Percent_Identity=21.9931271477663, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=25.1063829787234, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=25.1063829787234, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI87082310, Length=439, Percent_Identity=99.7722095671982, Blast_Score=880, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=431, Percent_Identity=37.8190255220418, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI2367259, Length=463, Percent_Identity=32.829373650108, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI2367379, Length=453, Percent_Identity=22.075055187638, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17542316, Length=451, Percent_Identity=23.9467849223947, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133901854, Length=444, Percent_Identity=23.1981981981982, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=444, Percent_Identity=23.1981981981982, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133930953, Length=444, Percent_Identity=21.8468468468468, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561094, Length=398, Percent_Identity=21.608040201005, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656861, Length=416, Percent_Identity=26.2019230769231, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24656866, Length=416, Percent_Identity=26.2019230769231, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550478, Length=416, Percent_Identity=26.2019230769231, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48315; Mature: 48315

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGDALIPIVMAAAALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQTPREA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGDALIPIVMAAAALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQTPREA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]