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The map label for this gene is adiC [H]

Identifier: 157163580

GI number: 157163580

Start: 4359715

End: 4361052

Strand: Reverse

Name: adiC [H]

Synonym: EcHS_A4355

Alternate gene names: 157163580

Gene position: 4361052-4359715 (Counterclockwise)

Preceding gene: 157163581

Following gene: 157163579

Centisome position: 93.92

GC content: 53.66

Gene sequence:

>1338_bases
ATGTCTTCGGATGCTGATGCTCACAAAGTGGGCTTAATCCCCGTCACCCTGATGGTGTCGGGGAATATTATGGGGTCAGG
TGTTTTTCTGTTACCTGCAAACCTGGCCTCTACTGGCGGGATTGCCATTTATGGATGGTTGGTGACGATTATCGGTGCAC
TGGGGCTCTCGATGGTATACGCCAAAATGTCGTTCCTCGACCCAAGTCCTGGTGGTTCTTACGCTTACGCCCGCCGCTGC
TTTGGCCCGTTTCTCGGTTATCAAACCAACGTCCTCTACTGGCTGGCCTGCTGGATCGGCAATATCGCCATGGTGGTCAT
TGGCGTAGGATATTTAAGTTACTTCTTCCCGATTCTGAAAGATCCATTGGTATTAACCATCACCTGCGTCGTGGTGCTGT
GGATCTTCGTCCTGCTGAACATTGTCGGTCCGAAAATGATCACCCGTGTGCAGGCAGTTGCCACCGTGCTGGCGCTGATC
CCCATCGTCGGGATTGCCGTATTTGGCTGGTTCTGGTTCCGTGGTGAAACCTATATGGCGGCATGGAACGTCAGCGGCCT
GGGCACCTTCGGTGCAATTCAAAGTACCCTTAACGTTACGCTGTGGTCGTTCATCGGTGTGGAAAGTGCCTCCGTTGCCG
CAGGTGTGGTGAAAAACCCGAAACGCAATGTCCCTATCGCCACCATTGGTGGGGTATTGATTGCCGCCGTTTGCTATGTA
CTTTCTACCACCGCGATTATGGGGATGATCCCTAATGCCGCACTGCGCGTTTCTGCTTCGCCATTCGGTGATGCCGCACG
GATGGCGTTGGGTGACACCGCCGGGGCCATTGTTTCCTTCTGCGCAGCTGCGGGTTGCTTAGGTTCACTGGGCGGCTGGA
CGTTGCTGGCGGGGCAAACGGCGAAAGCCGCTGCCGATGACGGACTGTTCCCACCAATTTTTGCCCGTGTAAATAAAGCG
GGTACGCCAGTGGCGGGGCTGATTATCGTCGGTATTTTGATGACCATCTTCCAGCTCAGCAGCATTTCACCAAACGCGAC
CAAAGAGTTCGGTCTGGTTTCTTCCGTCTCGGTCATCTTTACACTGGTGCCATATCTTTACACCTGTGCGGCGTTACTGC
TGCTCGGACACGGTCACTTTGGTAAAGCACGCCCGGCATATCTGGCAGTTACTACCATTGCCTTCCTCTACTGCATCTGG
GCCGTGGTGGGGTCCGGAGCGAAAGAGGTTATGTGGTCATTTGTCACCCTGATGGTCATCACCGCCATGTATGCGCTGAA
TTACAACCGGCTACATAAAAACCCGTATCCCTTAGATGTACCAATAAGCAAAGATTAA

Upstream 100 bases:

>100_bases
ATCAGCGATAACCCGGTCGATAATAATTCAACTATCGAATGCAGGCGTATGATATGACGTAATTTATTGTCACGAAGCTC
GCCTTCGCAGGAGTTTAATT

Downstream 100 bases:

>100_bases
TTCCCCTTAATCCAGCAAACATAAAAGCCAACCTTAAGAACTTAAGGTTGGCTTAATTTTGCTTTGCGAGCATATGCGCA
CTTTGTTCGATGGAAACACC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDVPISKD

Sequences:

>Translated_445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDVPISKD
>Mature_444_residues
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCF
GPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIP
IVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVL
STTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAG
TPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWA
VVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDVPISKD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=363, Percent_Identity=23.4159779614325, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI115648022, Length=363, Percent_Identity=23.4159779614325, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=99.7752808988764, Blast_Score=880, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=38.7755102040816, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1786908, Length=437, Percent_Identity=32.7231121281465, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1787890, Length=431, Percent_Identity=29.4663573085847, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082250, Length=349, Percent_Identity=29.2263610315186, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=24.8780487804878, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=25.0549450549451, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=24.3107769423559, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786789, Length=370, Percent_Identity=21.3513513513514, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=398, Percent_Identity=22.3618090452261, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=342, Percent_Identity=25.4385964912281, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995388, Length=408, Percent_Identity=24.5098039215686, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=408, Percent_Identity=24.5098039215686, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=403, Percent_Identity=24.5657568238213, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=26.7409470752089, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=410, Percent_Identity=23.4146341463415, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982608, Length=409, Percent_Identity=23.2273838630807, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=312, Percent_Identity=22.4358974358974, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651635, Length=346, Percent_Identity=23.9884393063584, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651633, Length=346, Percent_Identity=23.9884393063584, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46871; Mature: 46740

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDVPISKD
HHHHHHCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDVPISKD
HHHHHHCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]