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The map label for this gene is trkH

Identifier: 157163323

GI number: 157163323

Start: 4063405

End: 4064856

Strand: Direct

Name: trkH

Synonym: EcHS_A4072

Alternate gene names: 157163323

Gene position: 4063405-4064856 (Clockwise)

Preceding gene: 157163322

Following gene: 157163324

Centisome position: 87.51

GC content: 52.89

Gene sequence:

>1452_bases
ATGCATTTTCGCGCCATTACCCGAATCGTTGGACTACTGGTCATCTTATTTTCAGGGACCATGATTATCCCTGGGCTGGT
AGCACTCATCTACCGGGATGGAGCGGGCCGCGCTTTTACCCAGACCTTTTTTGTCGCCCTCGCCATTGGCTCTATGCTGT
GGTGGCCGAACCGCAAAGAGAAGGGCGAACTGAAATCCCGTGAGGGGTTTCTGATAGTGGTGCTGTTTTGGACCGTGCTG
GGTAGTGTCGGTGCGCTCCCTTTTATCTTCTCGGAAAGCCCGAACCTCACGATTACCGATGCGTTTTTTGAATCTTTCTC
TGGCCTGACCACCACCGGGGCCACTACGCTGGTGGGGCTGGATTCGCTCCCTCATGCCATCCTCTTTTATCGCCAGATGC
TGCAATGGTTTGGCGGGATGGGGATCATCGTGTTAGCGGTTGCGATACTGCCTATCCTCGGCGTGGGTGGGATGCAGCTC
TATCGCGCAGAAATGCCCGGCCCGCTGAAAGATAACAAAATGCGCCCGCGAATTGCGGAAACGGCGAAAACCCTGTGGTT
GATTTATGTCTTGCTGACCGTCGCCTGTGCGCTGGCGTTGTGGTTTGCCGGAATGGATGCCTTTGATGCCATCGGCCATA
GCTTTGCGACTATCGCTATTGGCGGCTTCTCGACACATGATGCCAGTATCGGTTATTTCGACAGCCCGACTATTAACACT
ATCATTGCTATCTTCCTGCTGATCTCCGGCTGTAACTACGGTCTGCACTTTTCACTGTTAAGTGGGCGTAGTCTGAAGGT
TTATTGGCGCGATCCGGAATTTCGCATGTTTATCGGCGTACAGTTTACGCTGGTGGTTATTTGTACACTCGTACTGTGGT
TTCATAATGTCTACAGTTCGGCGCTGATGACAATTAACCAGGCGTTTTTCCAGGTGGTATCGATGGCGACAACCGCCGGG
TTTACGACTGACAGCATTGCCCGCTGGCCGCTCTTTTTGCCGGTACTGCTTTTATGTTCAGCTTTTATCGGCGGTTGTGC
CGGGTCAACGGGCGGTGGCCTGAAAGTGATCCGCATCCTGCTGCTGTTTAAGCAGGGGAACCGTGAGCTGAAACGACTGG
TGCATCCGAACGCCGTCTATAGCATTAAGCTGGGGAATCGCGCACTGCCGGAACGTATCCTCGAAGCCGTTTGGGGATTT
TTCTCCGCCTATGCATTGGTGTTTATTGTCAGTATGCTGGCGATTATCGCCACGGGCGTGGATGACTTTTCTGCTTTTGC
CTCGGTTGTTGCGACATTGAATAACCTGGGGCCGGGGCTTGGCGTGGTTGCTGATAACTTTACCAGTATGAACCCGGTGG
CTAAATGGATCCTGATTGCCAACATGCTGTTTGGTCGTCTCGAGGTCTTTACATTGCTGGTGCTCTTTACCCCGACTTTC
TGGCGTGAATGA

Upstream 100 bases:

>100_bases
TTTCCGCAAAGCTGGCGGATTTTAGCCGTGGTTCATTGCAATTGTTAGCGATTGAAGAATAATCCCCACTTCGTTTTGCA
GAACTAAGGAAGCGGCAGAG

Downstream 100 bases:

>100_bases
TGGAGTAATACGTGAAAACATTAATTCTTTTCTCAACAAGGGACGGACAAACGCGCGAGATTGCCTCCTACTTGGCTTCG
GAACTGAAAGAACTGGGGAT

Product: potassium transporter

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKEKGELKSREGFLIVVLFWTVL
GSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQL
YRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINT
IIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSSALMTINQAFFQVVSMATTAG
FTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGF
FSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTF
WRE

Sequences:

>Translated_483_residues
MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKEKGELKSREGFLIVVLFWTVL
GSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQL
YRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINT
IIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSSALMTINQAFFQVVSMATTAG
FTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGF
FSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTF
WRE
>Mature_483_residues
MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKEKGELKSREGFLIVVLFWTVL
GSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQL
YRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINT
IIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSSALMTINQAFFQVVSMATTAG
FTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGF
FSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTF
WRE

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family

Homologues:

Organism=Escherichia coli, GI48994987, Length=483, Percent_Identity=100, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1787626, Length=482, Percent_Identity=40.8713692946058, Blast_Score=393, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRKH_ECO57 (P0AFZ8)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A91226
- PIR:   G86072
- RefSeq:   NP_290479.1
- RefSeq:   NP_312804.1
- ProteinModelPortal:   P0AFZ8
- EnsemblBacteria:   EBESCT00000025610
- EnsemblBacteria:   EBESCT00000058790
- GeneID:   915125
- GeneID:   960311
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5371
- KEGG:   ecs:ECs4777
- GeneTree:   EBGT00050000011154
- HOGENOM:   HBG732766
- OMA:   HPRAIYT
- ProtClustDB:   PRK10750
- BioCyc:   ECOL83334:ECS4777-MONOMER
- InterPro:   IPR003445
- InterPro:   IPR004772
- TIGRFAMs:   TIGR00933

Pfam domain/function: PF02386 TrkH

EC number: NA

Molecular weight: Translated: 52960; Mature: 52960

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x188531d4)-; HASH(0x182ed37c)-; HASH(0x17f30c10)-; HASH(0x18db5164)-; HASH(0x18d03b14)-; HASH(0x18dad470)-; HASH(0x18642040)-; HASH(0x18c2dbcc)-; HASH(0x186aee70)-; HASH(0x187740b4)-; HASH(0x18da2640)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKE
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
KGELKSREGFLIVVLFWTVLGSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGL
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHCCCCCCCCCHHHHCC
DSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQLYRAEMPGPLKDNKMRPRIAE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHH
TAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHH
IIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSS
HHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
ALMTINQAFFQVVSMATTAGFTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRIL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGFFSAYALVFIVSMLAIIATGV
HHHHCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTF
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
WRE
CCH
>Mature Secondary Structure
MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKE
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
KGELKSREGFLIVVLFWTVLGSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGL
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHCCCCCCCCCHHHHCC
DSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQLYRAEMPGPLKDNKMRPRIAE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHH
TAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHH
IIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSS
HHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
ALMTINQAFFQVVSMATTAGFTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRIL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGFFSAYALVFIVSMLAIIATGV
HHHHCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTF
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
WRE
CCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796