Click here to switch to the map view.

The map label for this gene is ygfU

Identifier: 157162348

GI number: 157162348

Start: 3058881

End: 3060329

Strand: Direct

Name: ygfU

Synonym: EcHS_A3047

Alternate gene names: 157162348

Gene position: 3058881-3060329 (Clockwise)

Preceding gene: 157162345

Following gene: 157162349

Centisome position: 65.87

GC content: 49.14

Gene sequence:

>1449_bases
ATGAGCGCCATAGATTCCCAACTTCCCTCATCTTCTGGGCAAGACCGCCCAACTGATGAGGTTGACCGCATATTATCACC
AGGAAAGCTGATCATACTCGGTCTGCAACACGTCCTTGTCATGTACGCAGGTGCAGTCGCTGTTCCTCTTATGATTGGTG
ACCGACTGGGCCTCTCAAAAGAAGCTATTGCGATGCTCATTAGCTCGGATCTCTTTTGCTGCGGGATCGTCACATTATTG
CAATGTATCGGTATCGGCCGCTTTATGGGGATCCGCCTGCCGGTGATTATGTCGGTGACCTTTGCTGCTGTAACACCAAT
GATAGCCATTGGGATGAACCCGGATATCGGCCTGCTGGGGATATTTGGTGCCACTATTGCCGCGGGTTTTATCACCACAT
TATTAGCGCCACTTATCGGTCGCTTGATGCCTTTATTCCCGCCACTGGTTACCGGTGTGGTTATTACTTCTATTGGGCTT
AGCATCATTCAGGTGGGTATTGACTGGGCCGCCGGAGGTAAAGGGAATCCGCAATATGGTAATCCCGTTTATTTAGGTAT
CTCCTTTGCCGTCTTAATTTTTATCTTGCTCATTACTCGCTATGCGAAAGGATTTATGTCCAACGTCGCCGTATTACTGG
GGATTGTATTTGGCTTTTTACTTTCGTGGATGATGAATGAAGTCAATTTATCCGGGCTACATGATGCCTCGTGGTTTGCG
ATTGTCACCCCGATGTCGTTTGGTATGCCGATTTTCGATCCCGTTTCCATTCTGACCATGACTGCCGTGTTAATCATCGT
GTTTATCGAGTCGATGGGGATGTTCCTGGCACTGGGTGAAATAGTCGGTCGTAAACTCTCTTCACACGATATTATTCGCG
GGCTGCGTGTCGATGGCGTAGGGACAATGATAGGCGGAACGTTTAACAGCTTCCCCCACACGTCATTTTCACAAAACGTT
GGCCTGGTTAGCGTGACGCGTGTTCATAGCCGCTGGGTGTGTATTTCTTCGGGAATTATATTAATCCTGTTTGGCATGGT
GCCAAAAATGGCGGTGCTGGTCGCCTCCATTCCGCAATTTGTGCTGGGCGGCGCTGGGCTGGTGATGTTCGGCATGGTAC
TGGCGACAGGGATTCGAATTCTGTCGCGCTGTAACTACACCACCAACCGTTACAACCTCTATATTGTGGCGATCAGTCTC
GGCGTTGGCATGACTCCGACGCTCTCTCACGATTTCTTTTCTAAGTTACCGGCCGTACTGCAACCGCTGCTACATAGCGG
CATTATGCTCGCAACCCTTAGCGCCGTTGTGCTGAACGTCTTCTTTAATGGCTATCAGCATCATGCTGACCTGGTGAAGG
AATCCGTCTCTGATAAAGATTTAAAAGTCAGGACAGTACGTATGTGGCTTCTGATGCGCAAGCTGAAGAAAAATGAGCAT
GGAGAATAA

Upstream 100 bases:

>100_bases
CCTTCCTCGCAAAAACTGGCACTCCACGAGCATGTGTTTAGACAGTTTCATTAACGTAAACGGTTGCTTTTTACTCTGGC
GGGCGAAAGGAGAAACACTG

Downstream 100 bases:

>100_bases
TATGAATCTTTTAATGCGCGCTATATTCAGTCTGTTGTTGCTTTTTACTCTCTCTATTCCTGTCATTTCTGACTGTGTTG
CAATGGCCATTGAAAGTCGC

Product: putative xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLL
QCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGL
SIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNV
GLVSVTRVHSRWVCISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISL
GVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
GE

Sequences:

>Translated_482_residues
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLL
QCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGL
SIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNV
GLVSVTRVHSRWVCISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISL
GVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
GE
>Mature_481_residues
SAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQ
CIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLS
IIQVGIDWAAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAI
VTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVG
LVSVTRVHSRWVCISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLG
VGMTPTLSHDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEHG
E

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily

Homologues:

Organism=Homo sapiens, GI44680148, Length=444, Percent_Identity=25, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI40316845, Length=444, Percent_Identity=25, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=25.858123569794, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI44680143, Length=441, Percent_Identity=25.6235827664399, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI87082181, Length=482, Percent_Identity=100, Blast_Score=958, Evalue=0.0,
Organism=Escherichia coli, GI1790087, Length=460, Percent_Identity=28.695652173913, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082178, Length=465, Percent_Identity=26.4516129032258, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788843, Length=391, Percent_Identity=27.6214833759591, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081818, Length=457, Percent_Identity=25.8205689277899, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17558856, Length=472, Percent_Identity=23.5169491525424, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17541904, Length=463, Percent_Identity=20.9503239740821, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17542260, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=450, Percent_Identity=22.8888888888889, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=238, Percent_Identity=26.890756302521, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=427, Percent_Identity=24.1217798594848, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YGFU_ECOLI (Q46821)

Other databases:

- EMBL:   U28375
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H65072
- RefSeq:   AP_003447.1
- RefSeq:   NP_417364.2
- ProteinModelPortal:   Q46821
- DIP:   DIP-12176N
- STRING:   Q46821
- EnsemblBacteria:   EBESCT00000000553
- EnsemblBacteria:   EBESCT00000015907
- GeneID:   949017
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5470
- KEGG:   eco:b2888
- EchoBASE:   EB2882
- EcoGene:   EG13071
- eggNOG:   COG2233
- GeneTree:   EBGT00050000009612
- HOGENOM:   HBG470187
- OMA:   CFLLWRA
- ProtClustDB:   CLSK880522
- BioCyc:   EcoCyc:YGFU-MONOMER
- Genevestigator:   Q46821
- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043
- PANTHER:   PTHR11119:SF3
- PANTHER:   PTHR11119
- TIGRFAMs:   TIGR00801
- TIGRFAMs:   TIGR03173

Pfam domain/function: PF00860 Xan_ur_permease

EC number: NA

Molecular weight: Translated: 51759; Mature: 51628

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x172778b0)-; HASH(0x15bdc888)-; HASH(0x172e5d20)-; HASH(0x11df45a0)-; HASH(0x17144b04)-; HASH(0x16724f08)-; HASH(0x16798e44)-; HASH(0x1365b700)-; HASH(0x170eb840)-; HASH(0x161b007c)-; HASH(0x1232f468)-; HASH(0x172e39a0)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSK
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EAIAMLISSDLFCCGIVTLLQCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLG
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHH
IFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGV
EECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEECCC
GTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGMVPKMAVLVASIPQF
HHHHCCCCCCCCCCCCCCCCCEEEEEHHHHCEEEHHCCHHHHHHHHHHHHHHHHHHHHHH
VLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVL
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GE
CH
>Mature Secondary Structure 
SAIDSQLPSSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSK
CCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EAIAMLISSDLFCCGIVTLLQCIGIGRFMGIRLPVIMSVTFAAVTPMIAIGMNPDIGLLG
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHH
IFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFA
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVTPMSFGMPIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGV
EECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEECCC
GTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGMVPKMAVLVASIPQF
HHHHCCCCCCCCCCCCCCCCCEEEEEHHHHCEEEHHCCHHHHHHHHHHHHHHHHHHHHHH
VLGGAGLVMFGMVLATGIRILSRCNYTTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVL
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QPLLHSGIMLATLSAVVLNVFFNGYQHHADLVKESVSDKDLKVRTVRMWLLMRKLKKNEH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GE
CH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503