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The map label for this gene is srlR

Identifier: 157162153

GI number: 157162153

Start: 2846465

End: 2847238

Strand: Direct

Name: srlR

Synonym: EcHS_A2843

Alternate gene names: 157162153

Gene position: 2846465-2847238 (Clockwise)

Preceding gene: 157162152

Following gene: 157162154

Centisome position: 61.3

GC content: 48.71

Gene sequence:

>774_bases
ATGAAACCTCGTCAGCGTCAGGCCGCCATTCTGGAGTATCTGCAAAAGCAGGGTAAATGCTCGGTTGAAGAATTGGCGCA
ATACTTTGACACCACAGGCACAACCATTCGCAAAGATCTGGTCATTCTGGAACATGCCGGAACCGTCATTCGTACTTATG
GCGGAGTGGTGTTGAATAAAGAGGAATCCGATCCGCCTATCGATCATAAAACGCTCATCAACACCCACAAGAAAGAGCTG
ATTGCAGAAGCTGCCGTTAGTTTTATCCATGATGGCGATTCGATCATTCTTGATGCTGGCAGTACCGTTTTGCAGATGGT
TCCCCTGCTCTCGCGCTTTAATAACATCACGGTGATGACCAACAGCCTGCATATCGTCAATGCGCTATCCGAACTGGATA
ACGAACAAACTATCCTGATGCCAGGCGGAACATTTCGCAAAAAATCGGCCTCATTTCACGGGCAACTGGCAGAGAATGCC
TTCGAGCATTTCACCTTCGACAAATTATTCATGGGTACAGACGGCATCGATCTCAATGCGGGCGTAACCACCTTCAACGA
GGTTTATACCGTCAGTAAGGCAATGTGCAATGCCGCACGCGAAGTGATTTTGATGGCGGACTCATCAAAGTTTGGCCGTA
AAAGCCCCAACGTAGTTTGCAGTCTTGAAAGCGTCGATAAGCTGATTACCGACGCAGGTATCGATCCGGCGTTTCGTCAG
GCGCTGGAAGAGAAAGGGATCGATGTGATCATAACCGGAGAGAGCAATGAGTGA

Upstream 100 bases:

>100_bases
TCTATCATTGGCGCTTAAACTGAAACGTGGATAATTTCGTTGTGAATGTTACTTGCTTGCGAAGTTATCATTTTGAAACC
TAAATCAGGTAATCACGCCC

Downstream 100 bases:

>100_bases
AGCACTACTGAACGCGGGACGTCAGACGTTAATACTGGAATTGCAGGAAGCAAGCCGTTTACCGGAACGTCTGGGCGATG
ATTTTGTTCGCGCCGCCAAT

Product: DNA-binding transcriptional repressor SrlR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEEKGIDVIITGESNE

Sequences:

>Translated_257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEEKGIDVIITGESNE
>Mature_257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEEKGIDVIITGESNE

Specific function: Unknown

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789059, Length=257, Percent_Identity=100, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1789519, Length=254, Percent_Identity=35.4330708661417, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789829, Length=251, Percent_Identity=29.8804780876494, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788069, Length=234, Percent_Identity=31.1965811965812, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI226510968, Length=253, Percent_Identity=29.2490118577075, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082344, Length=254, Percent_Identity=27.1653543307087, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787540, Length=247, Percent_Identity=29.9595141700405, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790753, Length=251, Percent_Identity=28.2868525896414, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790635, Length=257, Percent_Identity=24.5136186770428, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789170, Length=231, Percent_Identity=27.7056277056277, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787063, Length=231, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRLR_ECOLI (P15082)

Other databases:

- EMBL:   J02708
- EMBL:   X13463
- EMBL:   U29579
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S01832
- RefSeq:   AP_003274.1
- RefSeq:   NP_417187.1
- ProteinModelPortal:   P15082
- SMR:   P15082
- DIP:   DIP-10919N
- MINT:   MINT-1226226
- STRING:   P15082
- EnsemblBacteria:   EBESCT00000000684
- EnsemblBacteria:   EBESCT00000000685
- EnsemblBacteria:   EBESCT00000017461
- GeneID:   948942
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2676
- KEGG:   eco:b2707
- EchoBASE:   EB0967
- EcoGene:   EG10974
- eggNOG:   COG1349
- GeneTree:   EBGT00070000031704
- HOGENOM:   HBG694151
- OMA:   PNIVCGL
- ProtClustDB:   PRK10434
- BioCyc:   EcoCyc:PD00283
- Genevestigator:   P15082
- GO:   GO:0005622
- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00420

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR

EC number: NA

Molecular weight: Translated: 28236; Mature: 28236

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00894 HTH_DEOR_1; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNK
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEEHHCCEEEEC
EESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
NSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNA
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHEECCCCCCCCC
GVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
CCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHH
ALEEKGIDVIITGESNE
HHHHCCCEEEEECCCCC
>Mature Secondary Structure
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNK
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEEHHCCEEEEC
EESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
NSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNA
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHEECCCCCCCCC
GVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
CCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHH
ALEEKGIDVIITGESNE
HHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3062173; 9278503; 9205837