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The map label for this gene is astC [H]

Identifier: 157161209

GI number: 157161209

Start: 1848844

End: 1850064

Strand: Reverse

Name: astC [H]

Synonym: EcHS_A1831

Alternate gene names: 157161209

Gene position: 1850064-1848844 (Counterclockwise)

Preceding gene: 157161220

Following gene: 157161208

Centisome position: 39.84

GC content: 55.2

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCTCCGGCACCCTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAAGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCGCTAAAACTGGCGCGTAAATTCGCTCACGACCGCTACGGCAGCCATAAGAGCGGCATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGTGGGCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCGGCGGATATTCGTCATGCTGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACTCTACCTGTGCGGT
GATTGTCGAACCCATCCAGGGGGAAGGCGGTGTGGTGCCAGCCAGCAACGCGTTTTTACAAGGTCTGCGTGAATTGTGTA
ACCGCCACAATGCGCTGTTGATTTTTGATGAAGTACAAACCGGCGTCGGGCGCACCGGGGAACTGTATGCCTATATGCAC
TACGGCGTGACGCCTGATCTGTTAACTACCGCCAAAGCGCTGGGCGGCGGTTTCCCGGTCGGTGCGTTGTTGGCAACCGA
AGAGTGCGCCCGCGTGATGACCGTTGGCACTCATGGCACCACCTATGGCGGTAATCCGCTGGCCTCGGCGGTGGCAGGCA
AAGTGCTGGAGCTCATCAACACACCAGAGATGCTTAATGGCGTTAAACAGCGTCACGACTGGTTTGTTGAGCGTCTTAAT
ACCCTTAATCACCGCTACGGTTTGTTCAGCGAAATTCGCGGCTTAGGTTTGTTGATTGGCTGTGTGCTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGCGAAAGCAGGCGTGATGGTACTGATTGCAGGTGGCAACGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTATTAACATATAAATAACGAAT
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGATCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TLNHRYGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TLNHRYGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNT
LNHRYGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.5646437994723, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=27.5395033860045, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.1535836177474, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.9620853080569, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=27.2511848341232, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=28.1653746770026, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24119277, Length=413, Percent_Identity=28.0871670702179, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI188536080, Length=431, Percent_Identity=23.2018561484919, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI38679950, Length=431, Percent_Identity=23.2018561484919, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI38679946, Length=431, Percent_Identity=23.2018561484919, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=99.5073891625616, Blast_Score=836, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=60.2015113350126, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=33.4170854271357, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=34.7593582887701, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.3589743589744, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786349, Length=312, Percent_Identity=33.0128205128205, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.2941176470588, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.8850574712644, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=33.7979094076655, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=29.3302540415704, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=33.9393939393939, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=39.8009950248756, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=400, Percent_Identity=33.5, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.9230769230769, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=367, Percent_Identity=27.2479564032698, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.6200527704486, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=28.9823008849558, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=28.9887640449438, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356575, Length=362, Percent_Identity=29.2817679558011, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=24.7086247086247, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=24.7086247086247, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=24.7086247086247, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43680; Mature: 43549

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTLNHRYGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTLNHRYGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA