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The map label for this gene is betA [H]

Identifier: 157159823

GI number: 157159823

Start: 382917

End: 384587

Strand: Reverse

Name: betA [H]

Synonym: EcHS_A0370

Alternate gene names: 157159823

Gene position: 384587-382917 (Counterclockwise)

Preceding gene: 157159824

Following gene: 157159820

Centisome position: 8.28

GC content: 57.39

Gene sequence:

>1671_bases
TTGCAATTTGACTACATCATTATTGGTGCCGGCTCAGCCGGCAACGTTCTCGCTACCCGTCTGACTGAAGATCCGAATAC
CTCCGTGCTGCTGCTTGAAGCGGGCGGCCCGGACTATCGCTTTGACTTCCGCACCCAGATGCCCGCAGCGCTGGCGTTCC
CACTACAGGGCAAACGCTACAACTGGGCCTATGAAACAGAGCCTGAACCGTTTATGAATAACCGCCGCATGGAGTGCGGA
CGCGGTAAAGGCCTGGGTGGATCGTCGCTGATCAACGGCATGTGCTACATCCGTGGCAATGCGCTGGATCTCGATAACTG
GGCGCAAGAACCCGGTCTGGAGAACTGGAGTTATCTCGACTGCCTGCCCTACTACCGCAAGGCCGAGACTCGCGATGTGG
GCGAGAACGACTACCACGGTGGCGATGGCCCGGTGAGCGTCACCACCTCCAAACCCGGCGTCAATCCGCTGTTTGAAGCG
ATGATTGAAGCGGGCGTGCAGGCAGGCTACCCGCGCACGGACGATCTCAACGGCTATCAGCAGGAAGGTTTTGGCCCGAT
GGATCGCACCGTCACGCCGCAGGGCCGTCGCGCCAGTACCGCGCGCGGTTATCTCGATCAGGCCAAATCGCGCCCTAACC
TGACCATTCGTACTCACGCTATGACCGATCACATCATTTTTGACGGCAAACGCGCGGTGGGCGTCGAATGGCTGGAAGGC
GACAGCACCATCCCAACCCGCGCAACGGCCAACAAAGAAGTGCTGTTATGTGCAGGCGCGATTGCCTCACCGCAGATCCT
GCAACGCTCCGGCGTCGGCAACGCTGAACTGCTGGCGGAGTTTGATATTCCGCTGGTGCATGAATTACCCGGCGTCGGCG
AAAATCTTCAGGATCATCTGGAGATGTATCTGCAATATGAGTGCAAAGAACCGGTTTCCCTCTACCCTGCCCTGCAGTGG
TGGAACCAACCGAAAATCGGTGCGGAGTGGCTGTTTGGCGGCACTGGCGTTGGTGCCAGCAACCACTTTGAAGCAGGTGG
ATTTATTCGCAGCCGTGAGGAATTTGCGTGGCCGAATATTCAGTACCATTTCCTGCCAGTAGCGATTAACTATAACGGCT
CGAATGCAGTGAAAGAGCACGGTTTCCAGTGCCACGTCGGCTCAATGCGCTCGCCAAGCCGTGGGCATGTGCGGATTAAA
TCCCGCGACCCGCACCAGCATCCGGCGATTCTGTTTAACTACATGTCGCACGAGCAGGACTGGCAGGAGTTCCGCGACGC
AATTCGCATCACCCGGGAGATCATGCATCAACCGGCGCTGGATCAGTATCGTGGCCGCGAAATCAGCCCCGGCACGGAAT
GTCAGACGGATGAACAGCTCGATGAGTTCGTGCGTAATCACGCCGAAACCGCCTTCCATCCGTGCGGTACCTGCAAAATG
GGCTACGACGAGATGTCCGTGGTTGACGGCGAAGGCCGCGTACACGGGTTAGAAGGCCTGCGTGTGGTGGATGCGTCGAT
TATGCCGCAGATTATCACCGGGAATTTGAACGCCACGACAATTATGATTGGCGAGAAAATAGCGGATATGATTCGTGGAC
AGGAAGCGCTGCCGAGGAGCACGGCGGGATATTTTGTGGCAAATGGGATGCCGGTGAGAGCGAAAAAATGA

Upstream 100 bases:

>100_bases
CGCGAGAACGGCGTGATGACGCTCCAGAGTTACACCCAGGTGAAGTCCATCCAGGTTGAGATGGCTAAATTCCAGTCCAT
ATTCTAACCAGGAGGTTTAT

Downstream 100 bases:

>100_bases
GTCGTGATTTGAACTGACTCAAGAACCGATCTGATTGAGAGTTACCGTTCCAGGTATGGGGACAGAATCGTTATATAAAA
CATAGGGGTAACTCTCATGC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK

Sequences:

>Translated_556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK
>Mature_556_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRDPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRSTAGYFVANGMPVRAKK

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=48.4346224677716, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786503, Length=556, Percent_Identity=99.6402877697842, Blast_Score=1159, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=44.2273534635879, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24642048, Length=573, Percent_Identity=35.2530541012216, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=36.077057793345, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=34.4405594405594, Blast_Score=291, Evalue=8e-79,
Organism=Drosophila melanogaster, GI45549471, Length=574, Percent_Identity=34.4947735191638, Blast_Score=291, Evalue=9e-79,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=34.6689895470383, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24642055, Length=581, Percent_Identity=34.4234079173838, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=35.1158645276292, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=33.6236933797909, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24650267, Length=578, Percent_Identity=33.2179930795848, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=33.9160839160839, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=33.2746478873239, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=32.3478260869565, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24642037, Length=576, Percent_Identity=32.6388888888889, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI18859993, Length=573, Percent_Identity=33.1588132635253, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24645930, Length=585, Percent_Identity=27.8632478632479, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=29.0598290598291, Blast_Score=126, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 61848; Mature: 61848

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHL
CCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHCHHH
WQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCHHCCCC
TAGYFVANGMPVRAKK
CCCEEEECCEEECCCC
>Mature Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTSVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPQGRRASTARGYLDQAKSRPNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRATANKEVLLCAGAIASPQILQRSGVGNAELLAEFDIPLVHELPGVGENLQDHL
CCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGVGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRDPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHCHHH
WQEFRDAIRITREIMHQPALDQYRGREISPGTECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKIADMIRGQEALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCHHCCCC
TAGYFVANGMPVRAKK
CCCEEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA