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The map label for this gene is fimB [H]

Identifier: 157159819

GI number: 157159819

Start: 380502

End: 381023

Strand: Reverse

Name: fimB [H]

Synonym: EcHS_A0366

Alternate gene names: 157159819

Gene position: 381023-380502 (Counterclockwise)

Preceding gene: 157159820

Following gene: 157159818

Centisome position: 8.21

GC content: 41.57

Gene sequence:

>522_bases
ATGGATGCAGCCCAGAGTATGTCCTTTCCTGAAAGAAATCGCTGTCTAATTATGATGGCTTTCATTCACGGTTTTAGGGC
CAGTGAACTTCTTGATTTACGTTTATCCGATATTGATGCATCTGGAAAACAACTTAATATTCGGCGTATTAAAAATGGTT
TCTCGACAACACATCCTCTTCTTCCTGATGAATATAATTTGATCAAGTTGTGGCTTAAGCAGAGGAAGTTAATTGAAAAC
GGAGTTGAAGGAGACTGGCTTTTTCTCTCCCGGAAACGCCGCCCTATCAGCAGACAACATTTTTTTTCTATCATTCGTGA
GGCTGGAAAACGTGCAGGATTAGCTGTAAAAGCACATCCTCATATGTTACGTCATGCCTGTGGTTTTGCTCTGGCTGACA
ATGGTGTCGATACCCGACTACTTCAGGATTATCTGGGTCATCGAAATATTCAGCATACTGTCAGATACACAGCCAGTAAT
GCTGCTCGTTTTAAAGGGGTGTGGAAAAAAAAGCCTCGTTAA

Upstream 100 bases:

>100_bases
GCTGTCGTTCTCAAAATCGGTGGAGCTGCATGACAAAGTCATCGGGCATTATCTGAACATAAAACACTATCAATAAGTTG
GAGTCATTACCTACAGGCTG

Downstream 100 bases:

>100_bases
AACAGTACCTTCTGATTCAAAATGTCAGATTCCTACGTTTTCCTCAATTCTTCCATAAAAAAACAGCCCATTCAATTAAA
TAAAACACATAACATGTTGA

Product: phage integrase family site specific recombinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MDAAQSMSFPERNRCLIMMAFIHGFRASELLDLRLSDIDASGKQLNIRRIKNGFSTTHPLLPDEYNLIKLWLKQRKLIEN
GVEGDWLFLSRKRRPISRQHFFSIIREAGKRAGLAVKAHPHMLRHACGFALADNGVDTRLLQDYLGHRNIQHTVRYTASN
AARFKGVWKKKPR

Sequences:

>Translated_173_residues
MDAAQSMSFPERNRCLIMMAFIHGFRASELLDLRLSDIDASGKQLNIRRIKNGFSTTHPLLPDEYNLIKLWLKQRKLIEN
GVEGDWLFLSRKRRPISRQHFFSIIREAGKRAGLAVKAHPHMLRHACGFALADNGVDTRLLQDYLGHRNIQHTVRYTASN
AARFKGVWKKKPR
>Mature_173_residues
MDAAQSMSFPERNRCLIMMAFIHGFRASELLDLRLSDIDASGKQLNIRRIKNGFSTTHPLLPDEYNLIKLWLKQRKLIEN
GVEGDWLFLSRKRRPISRQHFFSIIREAGKRAGLAVKAHPHMLRHACGFALADNGVDTRLLQDYLGHRNIQHTVRYTASN
AARFKGVWKKKPR

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=170, Percent_Identity=57.0588235294118, Blast_Score=204, Evalue=2e-54,
Organism=Escherichia coli, GI1790768, Length=170, Percent_Identity=52.9411764705882, Blast_Score=191, Evalue=2e-50,
Organism=Escherichia coli, GI1789261, Length=157, Percent_Identity=32.484076433121, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790244, Length=153, Percent_Identity=32.0261437908497, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 20005; Mature: 20005

Theoretical pI: Translated: 11.29; Mature: 11.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAQSMSFPERNRCLIMMAFIHGFRASELLDLRLSDIDASGKQLNIRRIKNGFSTTHPL
CCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCCC
LPDEYNLIKLWLKQRKLIENGVEGDWLFLSRKRRPISRQHFFSIIREAGKRAGLAVKAHP
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEECCH
HMLRHACGFALADNGVDTRLLQDYLGHRNIQHTVRYTASNAARFKGVWKKKPR
HHHHHHHCHHHCCCCCHHHHHHHHHCCCCHHHHHEECCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MDAAQSMSFPERNRCLIMMAFIHGFRASELLDLRLSDIDASGKQLNIRRIKNGFSTTHPL
CCCCCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCCC
LPDEYNLIKLWLKQRKLIENGVEGDWLFLSRKRRPISRQHFFSIIREAGKRAGLAVKAHP
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEECCH
HMLRHACGFALADNGVDTRLLQDYLGHRNIQHTVRYTASNAARFKGVWKKKPR
HHHHHHHCHHHCCCCCHHHHHHHHHCCCCHHHHHEECCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]