Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 156978285

GI number: 156978285

Start: 2164690

End: 2165325

Strand: Direct

Name: pdxH

Synonym: VIBHAR_07092

Alternate gene names: 156978285

Gene position: 2164690-2165325 (Clockwise)

Preceding gene: 156978279

Following gene: 156978286

Centisome position: 98.22

GC content: 50.16

Gene sequence:

>636_bases
ATGGAACTTGCTGATATTCGTCGTGAGTACACAAAAGGTGGCCTGCGTCGTAAAGATTTAAAAGCAGATCCGATTGATCA
ATTTAACCTTTGGTTAGAGCAAGCGGTACAAGCTGGTATGACTGACCCGACGGCGATGACAGTCGCGACAGTCGATGAAA
ATGGTATGCCGTTTCAACGCATTGTGCTGCTAAAAAGTGTCGATAAAGATGGCTTTGTGTTCTACACCAACTTGGGCAGC
CGCAAAGCGCAGCAGCTTGGGCATAACAGCAACATCAGCCTGCATTTCCCATGGCACCCCCTTGAGCGTCAGGTTCACAT
CACGGGCGTGGCAGAAAAGCTAACGCCGATGGAGAACATGAAGTACTTCACTTCTCGCCCGAAAGAGAGCCAATTAGCAG
CGATCGCGAGCAAGCAAAGCAGCCGTATCTCTGCACGTGGCGTATTGGAAGGTAAGTTTTTAGAGCTGAAGCAGAAGTTT
GCTAAAGGTGAGATTCCTATGCCAACCTTCTGGGGTGGTTTCCGCGTTAAGCCACAAAGCATTGAGTTCTGGCAAGGCGG
TGAGCACCGTCTGCATGACCGCTTCTTGTTCTCAAATCAAGAAGGTGAGTGGGACATCGACCGTCTTGCGCCGTAG

Upstream 100 bases:

>100_bases
CGTGACACAGCACAAAACTGCAATCAGGGTTCTTGCTTGCTGTCCTTGTATTTCCTTAGTATCGGGCGCACAATCGACAA
AAACGAGTGAAGGAGTGAAG

Downstream 100 bases:

>100_bases
TCACTTCGATGACGAGATAAAAAAACACCGCCGAAATGGGCGGTGTTTTTGTTTTCTAGTTTGGAAATTCAACGTTCGCC
GTTGAGAACAACAGACAACT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQRIVLLKSVDKDGFVFYTNLGS
RKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENMKYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKF
AKGEIPMPTFWGGFRVKPQSIEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP

Sequences:

>Translated_211_residues
MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQRIVLLKSVDKDGFVFYTNLGS
RKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENMKYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKF
AKGEIPMPTFWGGFRVKPQSIEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP
>Mature_211_residues
MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQRIVLLKSVDKDGFVFYTNLGS
RKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENMKYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKF
AKGEIPMPTFWGGFRVKPQSIEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=230, Percent_Identity=40.8695652173913, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1787926, Length=210, Percent_Identity=66.6666666666667, Blast_Score=303, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17553712, Length=221, Percent_Identity=34.841628959276, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=38.755980861244, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551845, Length=206, Percent_Identity=41.2621359223301, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24644901, Length=206, Percent_Identity=41.2621359223301, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644903, Length=183, Percent_Identity=32.2404371584699, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_VIBHB (A7N7P0)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001449191.1
- ProteinModelPortal:   A7N7P0
- SMR:   A7N7P0
- STRING:   A7N7P0
- GeneID:   5558772
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_07092
- NMPDR:   fig|338187.4.peg.4195
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24175; Mature: 24175

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 60-60 BINDING 63-63 BINDING 65-65 BINDING 82-82 BINDING 122-122 BINDING 126-126 BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQR
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHH
IVLLKSVDKDGFVFYTNLGSRKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENM
HHEEHHCCCCCEEEEECCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEEHHHHHCCHHHH
KYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKFAKGEIPMPTFWGGFRVKPQS
HHHHCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCC
IEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP
EEECCCCCCHHHHHEEECCCCCCCCHHCCCC
>Mature Secondary Structure
MELADIRREYTKGGLRRKDLKADPIDQFNLWLEQAVQAGMTDPTAMTVATVDENGMPFQR
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHH
IVLLKSVDKDGFVFYTNLGSRKAQQLGHNSNISLHFPWHPLERQVHITGVAEKLTPMENM
HHEEHHCCCCCEEEEECCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEEHHHHHCCHHHH
KYFTSRPKESQLAAIASKQSSRISARGVLEGKFLELKQKFAKGEIPMPTFWGGFRVKPQS
HHHHCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCC
IEFWQGGEHRLHDRFLFSNQEGEWDIDRLAP
EEECCCCCCHHHHHEEECCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA