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The map label for this gene is luxQ [H]

Identifier: 156978233

GI number: 156978233

Start: 2112446

End: 2114371

Strand: Reverse

Name: luxQ [H]

Synonym: VIBHAR_07038

Alternate gene names: 156978233

Gene position: 2114371-2112446 (Counterclockwise)

Preceding gene: 156978235

Following gene: 156978232

Centisome position: 95.93

GC content: 45.85

Gene sequence:

>1926_bases
ATGGAGATAAAAGAGCGAGCTCAGCGCCGATTTAGTATCGGAAATCAATTGATGCTGGCGATTTTTGTGTTGAGTTTAAT
CTTTACCATAATCAGCTCTTCCATCAGTTTATATCGTGATTTCAACGATGATCTTGCTCGTCTGGATAGTGAGCTTGAGC
AGGTGAAAACCAGTTACTTATCCAGTTTTTCTGCCAGTTTGTGGGTTGAAGATCGAGAGCTATTACTTACTCAGGCAGAA
GGAGCAATGCGTTTACCCTCGGTGGATTATTTAAGAATTGCGACGCCAGATGAAGTGATCTTCGAACTAGGCAGCGCATT
AACGGAAGATCGGATCGAGCGGCAGTGGCCCTTGCAATACGATATGGGGGTAAAAACTTATGATCTTGCTGAAGTCACAG
TTCAAACGGATCTTACCCCGATCTATCAAGGGTTATGGCAAACCTTCTTTTTTCTGGTGATCGCGGAAGCGATCAAGATC
TTTTTACTCATCCTAGGTGTTTTGTGGGTCACGTTTCGCTTGATGGTGAAGCCTCTAGAGCTGCTCTCTGGGGCCGTAAG
CGATTTCAGCGGGGGCCATGTACCAAGCAAAGTGACATTGCCCAAACGTTGGTTCTTTGATGAAGTCAGTTTGTTGGAGC
GCAAATACAACCGAAGCGTTGAGCGTGTCAGTGAACACCAATTAGAAATTGAACAAGCGCGCGATAAAGCTGAAGTCGCA
AACCGAAAGAAAAGCGAATTCCTTGCCACCATGAGTCATGAGATTCGCACACCAATGAACGGCATTATTGGTATTGCTTC
GTTGCTCGGAGATACCAAACTCGATGAGCAACAAAAAGACTTCGTATCCATAATCAATAGCTCTTCCAACTCGCTAATGG
TGATCATAGACGACATCCTCGACTTTTCGAAAATTGAAGCGGGTAAGATTGAACTGGAAGCCACGACCTACAATCTACTC
GATTTACTTCACGAGGTAGGGCGTCTTCATACCGTCAAAGCGCAGCAGAAAGGTCTACAACTGGTTTGTGATATCGACCC
TCAGTTACCGTTAGAGGTGAAAGGGGATATGGGCAGACTCAAACAAGTGTTGAGCAATTTGCTCAGTAACGCAGTGAAGT
TCACTGAGCGTGGACACGTCAAGTTGATGGTGTCACTGGTGAGTCGGAAAACAGATATTGCCAGCGTGCATTTTCGAGTG
GTGGACTCAGGCATTGGCATTGCTAAAGAAAACCAGCAAACGGTATTTGAGAAGTTTCAGCAAGCCGATGGCAGTACCAC
GCGTAAATACGGCGGCACTGGTTTGGGCTTAGCAATCTGCAACAGTTTAGTTGAAGTTATGGGCGGGGAAATCCGTCTGA
CCAGTGAACCTGGTTTAGGCAGCTACTTTGAATTCACCATTCCACTCAATATCGTCTGTGATAAGTCTATCTCTCCTCAG
ACGCCTAACGTGTTTGATTTTCCGAATGGGATGAGCGATGCAATTGTTGCTGAGCATATCCAAACGACCAAAGATGTGGG
CAAGCCTTGGATTCTGGTCGTTGAAGACACGGCGGTGAATCAGAAAGTCGTGCGAATGATGTTAGAGAAACTTGGCATGC
AGGTGAATGTCGCCGAACACGGTAAAGATGCACTTCGACAATGCCAAACTCATCAGTTCGATTTAATTCTGATGGACTGC
CAAATGCCAGTCATGGATGGATTCATTGCCACTGAAAACATTCGTAAGATGGGCGAGTGGGGACAGCAAGTGCCGATCAT
TGCTTTAAGTGCCAATGTAATTAAAGAAGCTCAACAACGCTGCTTTGATGCAGGGATGAACGAATTTGTTGCCAAACCGG
TGACAAAAGAGCGCTTGCAGCAAATCTTTGAGCGATACCTACCAGAGTCATTGCAAACGCGATCGAATCCGAAACAAGCA
ACTTGA

Upstream 100 bases:

>100_bases
CTAAAGCCTAATGTTCGTAACAGTCCTTTCATCCTAACCTCGATTATTGTCGCGACCTGACTATATTTATATTAGCGCAA
GTTTAAGGGAGCGATTTCAT

Downstream 100 bases:

>100_bases
AATTGATCAAGTAAAGTGCGTTTCACTTCTTAAAAGTCAAATCTGTATGCTATAGTGCGCGGCTAGTATTTATTAAAGTA
CCTTGAGGCTGTGAATGTCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MEIKERAQRRFSIGNQLMLAIFVLSLIFTIISSSISLYRDFNDDLARLDSELEQVKTSYLSSFSASLWVEDRELLLTQAE
GAMRLPSVDYLRIATPDEVIFELGSALTEDRIERQWPLQYDMGVKTYDLAEVTVQTDLTPIYQGLWQTFFFLVIAEAIKI
FLLILGVLWVTFRLMVKPLELLSGAVSDFSGGHVPSKVTLPKRWFFDEVSLLERKYNRSVERVSEHQLEIEQARDKAEVA
NRKKSEFLATMSHEIRTPMNGIIGIASLLGDTKLDEQQKDFVSIINSSSNSLMVIIDDILDFSKIEAGKIELEATTYNLL
DLLHEVGRLHTVKAQQKGLQLVCDIDPQLPLEVKGDMGRLKQVLSNLLSNAVKFTERGHVKLMVSLVSRKTDIASVHFRV
VDSGIGIAKENQQTVFEKFQQADGSTTRKYGGTGLGLAICNSLVEVMGGEIRLTSEPGLGSYFEFTIPLNIVCDKSISPQ
TPNVFDFPNGMSDAIVAEHIQTTKDVGKPWILVVEDTAVNQKVVRMMLEKLGMQVNVAEHGKDALRQCQTHQFDLILMDC
QMPVMDGFIATENIRKMGEWGQQVPIIALSANVIKEAQQRCFDAGMNEFVAKPVTKERLQQIFERYLPESLQTRSNPKQA
T

Sequences:

>Translated_641_residues
MEIKERAQRRFSIGNQLMLAIFVLSLIFTIISSSISLYRDFNDDLARLDSELEQVKTSYLSSFSASLWVEDRELLLTQAE
GAMRLPSVDYLRIATPDEVIFELGSALTEDRIERQWPLQYDMGVKTYDLAEVTVQTDLTPIYQGLWQTFFFLVIAEAIKI
FLLILGVLWVTFRLMVKPLELLSGAVSDFSGGHVPSKVTLPKRWFFDEVSLLERKYNRSVERVSEHQLEIEQARDKAEVA
NRKKSEFLATMSHEIRTPMNGIIGIASLLGDTKLDEQQKDFVSIINSSSNSLMVIIDDILDFSKIEAGKIELEATTYNLL
DLLHEVGRLHTVKAQQKGLQLVCDIDPQLPLEVKGDMGRLKQVLSNLLSNAVKFTERGHVKLMVSLVSRKTDIASVHFRV
VDSGIGIAKENQQTVFEKFQQADGSTTRKYGGTGLGLAICNSLVEVMGGEIRLTSEPGLGSYFEFTIPLNIVCDKSISPQ
TPNVFDFPNGMSDAIVAEHIQTTKDVGKPWILVVEDTAVNQKVVRMMLEKLGMQVNVAEHGKDALRQCQTHQFDLILMDC
QMPVMDGFIATENIRKMGEWGQQVPIIALSANVIKEAQQRCFDAGMNEFVAKPVTKERLQQIFERYLPESLQTRSNPKQA
T
>Mature_641_residues
MEIKERAQRRFSIGNQLMLAIFVLSLIFTIISSSISLYRDFNDDLARLDSELEQVKTSYLSSFSASLWVEDRELLLTQAE
GAMRLPSVDYLRIATPDEVIFELGSALTEDRIERQWPLQYDMGVKTYDLAEVTVQTDLTPIYQGLWQTFFFLVIAEAIKI
FLLILGVLWVTFRLMVKPLELLSGAVSDFSGGHVPSKVTLPKRWFFDEVSLLERKYNRSVERVSEHQLEIEQARDKAEVA
NRKKSEFLATMSHEIRTPMNGIIGIASLLGDTKLDEQQKDFVSIINSSSNSLMVIIDDILDFSKIEAGKIELEATTYNLL
DLLHEVGRLHTVKAQQKGLQLVCDIDPQLPLEVKGDMGRLKQVLSNLLSNAVKFTERGHVKLMVSLVSRKTDIASVHFRV
VDSGIGIAKENQQTVFEKFQQADGSTTRKYGGTGLGLAICNSLVEVMGGEIRLTSEPGLGSYFEFTIPLNIVCDKSISPQ
TPNVFDFPNGMSDAIVAEHIQTTKDVGKPWILVVEDTAVNQKVVRMMLEKLGMQVNVAEHGKDALRQCQTHQFDLILMDC
QMPVMDGFIATENIRKMGEWGQQVPIIALSANVIKEAQQRCFDAGMNEFVAKPVTKERLQQIFERYLPESLQTRSNPKQA
T

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=403, Percent_Identity=35.7320099255583, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789149, Length=253, Percent_Identity=42.6877470355731, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1788713, Length=395, Percent_Identity=34.4303797468354, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081816, Length=528, Percent_Identity=30.3030303030303, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=41.5322580645161, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788393, Length=297, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=33.0472103004292, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=28.5106382978723, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=27.9661016949153, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=28.957528957529, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=328, Percent_Identity=28.3536585365854, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=27.2, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=340, Percent_Identity=27.3529411764706, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=27.8260869565217, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=276, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=34.453781512605, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=155, Percent_Identity=32.9032258064516, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322000, Length=117, Percent_Identity=35.8974358974359, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72183; Mature: 72183

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKERAQRRFSIGNQLMLAIFVLSLIFTIISSSISLYRDFNDDLARLDSELEQVKTSYL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SSFSASLWVEDRELLLTQAEGAMRLPSVDYLRIATPDEVIFELGSALTEDRIERQWPLQY
HHHHHHHEECHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCC
DMGVKTYDLAEVTVQTDLTPIYQGLWQTFFFLVIAEAIKIFLLILGVLWVTFRLMVKPLE
CCCCCEEEHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSGAVSDFSGGHVPSKVTLPKRWFFDEVSLLERKYNRSVERVSEHQLEIEQARDKAEVA
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRKKSEFLATMSHEIRTPMNGIIGIASLLGDTKLDEQQKDFVSIINSSSNSLMVIIDDIL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHH
DFSKIEAGKIELEATTYNLLDLLHEVGRLHTVKAQQKGLQLVCDIDPQLPLEVKGDMGRL
CHHHCCCCEEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECCCCCCCEECCCHHHH
KQVLSNLLSNAVKFTERGHVKLMVSLVSRKTDIASVHFRVVDSGIGIAKENQQTVFEKFQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHH
QADGSTTRKYGGTGLGLAICNSLVEVMGGEIRLTSEPGLGSYFEFTIPLNIVCDKSISPQ
HCCCCCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCC
TPNVFDFPNGMSDAIVAEHIQTTKDVGKPWILVVEDTAVNQKVVRMMLEKLGMQVNVAEH
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEHHC
GKDALRQCQTHQFDLILMDCQMPVMDGFIATENIRKMGEWGQQVPIIALSANVIKEAQQR
CHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
CFDAGMNEFVAKPVTKERLQQIFERYLPESLQTRSNPKQAT
HHHHCHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCC
>Mature Secondary Structure
MEIKERAQRRFSIGNQLMLAIFVLSLIFTIISSSISLYRDFNDDLARLDSELEQVKTSYL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SSFSASLWVEDRELLLTQAEGAMRLPSVDYLRIATPDEVIFELGSALTEDRIERQWPLQY
HHHHHHHEECHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCC
DMGVKTYDLAEVTVQTDLTPIYQGLWQTFFFLVIAEAIKIFLLILGVLWVTFRLMVKPLE
CCCCCEEEHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSGAVSDFSGGHVPSKVTLPKRWFFDEVSLLERKYNRSVERVSEHQLEIEQARDKAEVA
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRKKSEFLATMSHEIRTPMNGIIGIASLLGDTKLDEQQKDFVSIINSSSNSLMVIIDDIL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHH
DFSKIEAGKIELEATTYNLLDLLHEVGRLHTVKAQQKGLQLVCDIDPQLPLEVKGDMGRL
CHHHCCCCEEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECCCCCCCEECCCHHHH
KQVLSNLLSNAVKFTERGHVKLMVSLVSRKTDIASVHFRVVDSGIGIAKENQQTVFEKFQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHH
QADGSTTRKYGGTGLGLAICNSLVEVMGGEIRLTSEPGLGSYFEFTIPLNIVCDKSISPQ
HCCCCCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCC
TPNVFDFPNGMSDAIVAEHIQTTKDVGKPWILVVEDTAVNQKVVRMMLEKLGMQVNVAEH
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEHHC
GKDALRQCQTHQFDLILMDCQMPVMDGFIATENIRKMGEWGQQVPIIALSANVIKEAQQR
CHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
CFDAGMNEFVAKPVTKERLQQIFERYLPESLQTRSNPKQAT
HHHHCHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]