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The map label for this gene is ppiB [H]

Identifier: 156978218

GI number: 156978218

Start: 2099363

End: 2099857

Strand: Direct

Name: ppiB [H]

Synonym: VIBHAR_07023

Alternate gene names: 156978218

Gene position: 2099363-2099857 (Clockwise)

Preceding gene: 156978217

Following gene: 156978227

Centisome position: 95.25

GC content: 47.47

Gene sequence:

>495_bases
ATGATTATTATGACCACCAATTTCGGTGACATCGAGATTGAACTGAACCTAGAACGAGCACCAGTTAGCTCAAAGAACTT
CAAAAAATACTGTGAAGATGGCTTCTACAACGGCACCATTTTCCACCGCGTTATCGACGGCTTTATGATCCAAGGTGGCG
GTCACACCGAAGACATGGCAGAAAAGCCAACGCGCGCTCCGATCGCGAACGAAGCAAACCGTGGTCTAAAGAACCTTGTT
GGCACTATCGCAATGGCGCGTACCGATGCACCACACTCTGCAACAGCTCAGTTCTTCATTAACTTGGAAGACAATGATTT
TCTAGACCACACTGCAACCACCAACCTAGGCTGGGGTTACGCGGTGTTTGGTAAAGTGACCGCGGGTATGGATGTCGTAA
ACCGTATCGCGAAAGTGAAAACGACCTCTAAACTTGGTCACGATGATGTGCCATGCGATCCAATCATTATTGAGAAAGTG
ACAGTCAGCGAATAA

Upstream 100 bases:

>100_bases
TGCAAACAGCGACGCCAAAACGTCGCTGTTTTTATTTCTGCTATCATAATGCGACTTAGCTATAATGCCGCCAACTTAGC
ACCCACAAGGGCAAAACCAG

Downstream 100 bases:

>100_bases
GCCCATTCGCCTCTTCGGAGAAATCGTCGCTCCAAAACTAAGAAAGCGCCTAATGTCTTATGACCTAGGCGCTTTTTGTT
TTTATTGCTGAAAAAATGAG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIIMTTNFGDIEIELNLERAPVSSKNFKKYCEDGFYNGTIFHRVIDGFMIQGGGHTEDMAEKPTRAPIANEANRGLKNLV
GTIAMARTDAPHSATAQFFINLEDNDFLDHTATTNLGWGYAVFGKVTAGMDVVNRIAKVKTTSKLGHDDVPCDPIIIEKV
TVSE

Sequences:

>Translated_164_residues
MIIMTTNFGDIEIELNLERAPVSSKNFKKYCEDGFYNGTIFHRVIDGFMIQGGGHTEDMAEKPTRAPIANEANRGLKNLV
GTIAMARTDAPHSATAQFFINLEDNDFLDHTATTNLGWGYAVFGKVTAGMDVVNRIAKVKTTSKLGHDDVPCDPIIIEKV
TVSE
>Mature_164_residues
MIIMTTNFGDIEIELNLERAPVSSKNFKKYCEDGFYNGTIFHRVIDGFMIQGGGHTEDMAEKPTRAPIANEANRGLKNLV
GTIAMARTDAPHSATAQFFINLEDNDFLDHTATTNLGWGYAVFGKVTAGMDVVNRIAKVKTTSKLGHDDVPCDPIIIEKV
TVSE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=34.5454545454545, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI19557636, Length=164, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI64276486, Length=166, Percent_Identity=34.9397590361446, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=32.9411764705882, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.3170731707317, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.3170731707317, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.3170731707317, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=31.9018404907975, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=59.1463414634146, Blast_Score=195, Evalue=1e-51,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=53.416149068323, Blast_Score=173, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=171, Percent_Identity=33.9181286549708, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=162, Percent_Identity=32.0987654320988, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=169, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=35.1351351351351, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=35.4609929078014, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=33.5329341317365, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=30.2325581395349, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18009; Mature: 18009

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMTTNFGDIEIELNLERAPVSSKNFKKYCEDGFYNGTIFHRVIDGFMIQGGGHTEDMA
CEEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHHH
EKPTRAPIANEANRGLKNLVGTIAMARTDAPHSATAQFFINLEDNDFLDHTATTNLGWGY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
AVFGKVTAGMDVVNRIAKVKTTSKLGHDDVPCDPIIIEKVTVSE
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MIIMTTNFGDIEIELNLERAPVSSKNFKKYCEDGFYNGTIFHRVIDGFMIQGGGHTEDMA
CEEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHHH
EKPTRAPIANEANRGLKNLVGTIAMARTDAPHSATAQFFINLEDNDFLDHTATTNLGWGY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCH
AVFGKVTAGMDVVNRIAKVKTTSKLGHDDVPCDPIIIEKVTVSE
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]