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The map label for this gene is yeiG [H]

Identifier: 156978121

GI number: 156978121

Start: 2022404

End: 2023243

Strand: Direct

Name: yeiG [H]

Synonym: VIBHAR_06926

Alternate gene names: 156978121

Gene position: 2022404-2023243 (Clockwise)

Preceding gene: 156978120

Following gene: 156978122

Centisome position: 91.76

GC content: 48.1

Gene sequence:

>840_bases
ATGACCATTGAAAGCCTAAGCCAAGCCAAAGTATTCGGTGGTTGGCATAAACAGTACACTCACGAATCTCGCGCTTTGAA
CTGCAACATGCGCTTCGCGATCTTCTTGCCACCTAACGCGACCAAATCAAACCCAGTGCCTGTGGTTTACTGGTTGTCTG
GCTTGACATGTACCGATGAGAACTTCATGCAGAAAGCCGGTGCGTTTCGCATGGCGGCTGAGTTAGGTATCGCCATTGTG
GCACCGGATACCAGCCCACGTGGTGACGACGTTGCAGACGACGAAAACTACGATCTGGGTAAAGGCGCAGGTTTCTACCT
AAACGCCACTCAAGAGCCATGGTCACGCCACTACCATATGTACGATTACATCACCAAAGAATTGCCTGCGATCATTGAAA
ACAACTTCCCTGTTTCAGATGTTAAATCGATTTCGGGTCACAGCATGGGTGGTCACGGTGCAATCACCATTGGTCTGAAA
AATTCAGATCAGTACCGTTCAATTTCAGCGTTCAGCCCAATCAGTAACCCAATGCAATGTCCTTGGGGCCAAAAAGCGTT
TACCGCTTACCTAGGCACTGATATCGAAAGCTGGAAGCAGTACGACGCAAGCGAGTTGCTAAAGCAAGCAAAATCACCAT
TGCCAATCTTGGTAGATCAAGGTGATGCCGATAACTTCCTTGCTGAGCAATTAAAACCTGATGTGTTACTGGCGGCAGCA
AAAGCCCATGATTCTGAAGTCGAACTGCGCATGCAGCCGGGTTACGACCACAGCTACTTCTTTATCTCGAGCTTTATCGC
TGATCACTTGAACTTCCACGCTAAGTACTTATTTGCCTAA

Upstream 100 bases:

>100_bases
TTTAACGGTCTTGTCCGCCGTTAAAAATCATTGTTTTAAATATTCACTGTTTTAATTAAAGATTACTTTAACTAAACATT
GTTTTATCGAGAGATTATCC

Downstream 100 bases:

>100_bases
CGCCAATTTTAACGCCGCAAGCAAATAGAAGAGCGCGGAAAACCAAACGGTTTAATAATCTTCTCTATACAAAGCCATCC
AATTATTGGGTGGCTTTTTG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTIESLSQAKVFGGWHKQYTHESRALNCNMRFAIFLPPNATKSNPVPVVYWLSGLTCTDENFMQKAGAFRMAAELGIAIV
APDTSPRGDDVADDENYDLGKGAGFYLNATQEPWSRHYHMYDYITKELPAIIENNFPVSDVKSISGHSMGGHGAITIGLK
NSDQYRSISAFSPISNPMQCPWGQKAFTAYLGTDIESWKQYDASELLKQAKSPLPILVDQGDADNFLAEQLKPDVLLAAA
KAHDSEVELRMQPGYDHSYFFISSFIADHLNFHAKYLFA

Sequences:

>Translated_279_residues
MTIESLSQAKVFGGWHKQYTHESRALNCNMRFAIFLPPNATKSNPVPVVYWLSGLTCTDENFMQKAGAFRMAAELGIAIV
APDTSPRGDDVADDENYDLGKGAGFYLNATQEPWSRHYHMYDYITKELPAIIENNFPVSDVKSISGHSMGGHGAITIGLK
NSDQYRSISAFSPISNPMQCPWGQKAFTAYLGTDIESWKQYDASELLKQAKSPLPILVDQGDADNFLAEQLKPDVLLAAA
KAHDSEVELRMQPGYDHSYFFISSFIADHLNFHAKYLFA
>Mature_278_residues
TIESLSQAKVFGGWHKQYTHESRALNCNMRFAIFLPPNATKSNPVPVVYWLSGLTCTDENFMQKAGAFRMAAELGIAIVA
PDTSPRGDDVADDENYDLGKGAGFYLNATQEPWSRHYHMYDYITKELPAIIENNFPVSDVKSISGHSMGGHGAITIGLKN
SDQYRSISAFSPISNPMQCPWGQKAFTAYLGTDIESWKQYDASELLKQAKSPLPILVDQGDADNFLAEQLKPDVLLAAAK
AHDSEVELRMQPGYDHSYFFISSFIADHLNFHAKYLFA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=52.6501766784452, Blast_Score=314, Evalue=4e-86,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=57.5539568345324, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=51.2727272727273, Blast_Score=305, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=51.063829787234, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=44.9324324324324, Blast_Score=238, Evalue=7e-64,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=51.056338028169, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=51.056338028169, Blast_Score=298, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31058; Mature: 30927

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIESLSQAKVFGGWHKQYTHESRALNCNMRFAIFLPPNATKSNPVPVVYWLSGLTCTDE
CCCCHHHHHHHHCCHHHHHCCCCCEEECCEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAFRMAAELGIAIVAPDTSPRGDDVADDENYDLGKGAGFYLNATQEPWSRHYHM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCHH
YDYITKELPAIIENNFPVSDVKSISGHSMGGHGAITIGLKNSDQYRSISAFSPISNPMQC
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCC
PWGQKAFTAYLGTDIESWKQYDASELLKQAKSPLPILVDQGDADNFLAEQLKPDVLLAAA
CCCCHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCEEEEEE
KAHDSEVELRMQPGYDHSYFFISSFIADHLNFHAKYLFA
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
TIESLSQAKVFGGWHKQYTHESRALNCNMRFAIFLPPNATKSNPVPVVYWLSGLTCTDE
CCCHHHHHHHHCCHHHHHCCCCCEEECCEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAFRMAAELGIAIVAPDTSPRGDDVADDENYDLGKGAGFYLNATQEPWSRHYHM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCHH
YDYITKELPAIIENNFPVSDVKSISGHSMGGHGAITIGLKNSDQYRSISAFSPISNPMQC
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCC
PWGQKAFTAYLGTDIESWKQYDASELLKQAKSPLPILVDQGDADNFLAEQLKPDVLLAAA
CCCCHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCEEEEEE
KAHDSEVELRMQPGYDHSYFFISSFIADHLNFHAKYLFA
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA