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The map label for this gene is msrAB [H]

Identifier: 156977898

GI number: 156977898

Start: 1824651

End: 1825793

Strand: Direct

Name: msrAB [H]

Synonym: VIBHAR_06690

Alternate gene names: 156977898

Gene position: 1824651-1825793 (Clockwise)

Preceding gene: 156977894

Following gene: 156977902

Centisome position: 82.79

GC content: 44.18

Gene sequence:

>1143_bases
ATGAAGAAAGTATCTAAGTTGTTGGTGGGATTCTCATTCACACTCACTGTACTGTTCATCTTGCTAAGTAAAACAGGTGC
CGCCGATACCATGGATAAGATGAACGCATCTGGTAAAACTGACATCGCAACATTGGCAGGTGGTTGTTTCTGGTGTACCG
AATCGGATTTAGAGCAATTACCGGGTGTGTTAGACGTGGTTTCTGGTTACTCAGGTGGTGATTTAGAAAACCCAACTTAT
CGACAAGTCTCTTCTGGCAAATCCGGCCATATTGAAGTGATTGAGGTGAAGTACGATCCTGCTGTCGTGAATTACGAACA
AGTATTGGATTACTTCTTCCGCCATATCGACCCGACTGACGCCAAAGGCTCATTCGTCGACCGTGGTCCTCAATACCGCC
CGGCGATCTTCTATCATAATGCGGAGCAAAAGCAGATTGCTGAGCAGTTTATGATGGAAATCGACAAGGCGATGATCTAT
CCAAAACCGTTGAAAACAGAACTGATCGAGTTTGAAAAGTTCTACCCTGCGGAGTCGTACCATCAGGATTACTACAAGAA
GAGTAGCCTGAAGTACAAATACTACCGCTACGCATCAGGTCGCGATAAATACCTCGACGAAGTGTTTGGTGATGATCGTA
AAGACAACCCAAAAACACTGCGTGAACTTATCAACGAAAAAGAGCTGGTGTCGAAAGTGAAAGTGTACGAGAAACCTTCA
GACAAAGAAATCAAAGCTAAATTGACTGAGCTTCAATACTACGTGACACAAGAAGAAGGTACGGAACGCCCCTTTAACAA
CAAGTATTGGGATAACAAAGAAGCAGGCATTTACGTTGATATCGTCACTGGTGAGCCTTTGTTCTCATCAACAGATAAGT
ACAAATCTGGCACAGGTTGGCCAAGCTTTACCAGACCAATTAACCCACGCTACATCGTAGAGAAAACCGACTTTAAATTG
GTTTATCCGCGCACAGAGATCCGCAGTAAGTTTGGTGATTCGCATATTGGCCATGTATTTAAAGATGGCCCTAAGCCAAC
GGGATTACGTTACTGCATGAACTCAGCCGCAATGGAGTTTGTACCAGTGAACAAGATGGCGAGTTTAGGCTACGGCGATT
ACCTGTTCCTATTTGATAAGTAG

Upstream 100 bases:

>100_bases
AAAAAAGGGCAAAGAAATTTTCATCTTCACTGTAATTTTTTCGCTCTTCAGTCTGTCCTGTTACGTAAGATTCATTGAGA
AAATAACGTTTGAGGAAGTT

Downstream 100 bases:

>100_bases
CTAGGCCACTGTTTTAACCAAATTAGGAGTGAACATTCAGCGCAATGAAAGGTTTTAAATCCAACCTTCCCATGAAAGTC
TGTCCGGTCTGTCAGCGCCC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKKVSKLLVGFSFTLTVLFILLSKTGAADTMDKMNASGKTDIATLAGGCFWCTESDLEQLPGVLDVVSGYSGGDLENPTY
RQVSSGKSGHIEVIEVKYDPAVVNYEQVLDYFFRHIDPTDAKGSFVDRGPQYRPAIFYHNAEQKQIAEQFMMEIDKAMIY
PKPLKTELIEFEKFYPAESYHQDYYKKSSLKYKYYRYASGRDKYLDEVFGDDRKDNPKTLRELINEKELVSKVKVYEKPS
DKEIKAKLTELQYYVTQEEGTERPFNNKYWDNKEAGIYVDIVTGEPLFSSTDKYKSGTGWPSFTRPINPRYIVEKTDFKL
VYPRTEIRSKFGDSHIGHVFKDGPKPTGLRYCMNSAAMEFVPVNKMASLGYGDYLFLFDK

Sequences:

>Translated_380_residues
MKKVSKLLVGFSFTLTVLFILLSKTGAADTMDKMNASGKTDIATLAGGCFWCTESDLEQLPGVLDVVSGYSGGDLENPTY
RQVSSGKSGHIEVIEVKYDPAVVNYEQVLDYFFRHIDPTDAKGSFVDRGPQYRPAIFYHNAEQKQIAEQFMMEIDKAMIY
PKPLKTELIEFEKFYPAESYHQDYYKKSSLKYKYYRYASGRDKYLDEVFGDDRKDNPKTLRELINEKELVSKVKVYEKPS
DKEIKAKLTELQYYVTQEEGTERPFNNKYWDNKEAGIYVDIVTGEPLFSSTDKYKSGTGWPSFTRPINPRYIVEKTDFKL
VYPRTEIRSKFGDSHIGHVFKDGPKPTGLRYCMNSAAMEFVPVNKMASLGYGDYLFLFDK
>Mature_380_residues
MKKVSKLLVGFSFTLTVLFILLSKTGAADTMDKMNASGKTDIATLAGGCFWCTESDLEQLPGVLDVVSGYSGGDLENPTY
RQVSSGKSGHIEVIEVKYDPAVVNYEQVLDYFFRHIDPTDAKGSFVDRGPQYRPAIFYHNAEQKQIAEQFMMEIDKAMIY
PKPLKTELIEFEKFYPAESYHQDYYKKSSLKYKYYRYASGRDKYLDEVFGDDRKDNPKTLRELINEKELVSKVKVYEKPS
DKEIKAKLTELQYYVTQEEGTERPFNNKYWDNKEAGIYVDIVTGEPLFSSTDKYKSGTGWPSFTRPINPRYIVEKTDFKL
VYPRTEIRSKFGDSHIGHVFKDGPKPTGLRYCMNSAAMEFVPVNKMASLGYGDYLFLFDK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=129, Percent_Identity=46.5116279069767, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI301336162, Length=129, Percent_Identity=46.5116279069767, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI73089054, Length=129, Percent_Identity=46.5116279069767, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI37620216, Length=129, Percent_Identity=46.5116279069767, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=46.1538461538462, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=36.7741935483871, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=36.7741935483871, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=48.3870967741936, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790665, Length=165, Percent_Identity=38.1818181818182, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115532676, Length=136, Percent_Identity=42.6470588235294, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=136, Percent_Identity=42.6470588235294, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=138, Percent_Identity=35.5072463768116, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319816, Length=133, Percent_Identity=33.0827067669173, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24645799, Length=168, Percent_Identity=40.4761904761905, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45553335, Length=128, Percent_Identity=46.09375, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21356369, Length=128, Percent_Identity=46.09375, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24645801, Length=179, Percent_Identity=38.5474860335196, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645804, Length=139, Percent_Identity=43.1654676258993, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221378664, Length=121, Percent_Identity=44.6280991735537, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=43.5114503816794, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=38.7323943661972, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=38.6861313868613, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=37.3239436619718, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 43684; Mature: 43684

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSKLLVGFSFTLTVLFILLSKTGAADTMDKMNASGKTDIATLAGGCFWCTESDLEQL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHCCCEEECCCHHHHHC
PGVLDVVSGYSGGDLENPTYRQVSSGKSGHIEVIEVKYDPAVVNYEQVLDYFFRHIDPTD
CCHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHCCCCC
AKGSFVDRGPQYRPAIFYHNAEQKQIAEQFMMEIDKAMIYPKPLKTELIEFEKFYPAESY
CCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
HQDYYKKSSLKYKYYRYASGRDKYLDEVFGDDRKDNPKTLRELINEKELVSKVKVYEKPS
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DKEIKAKLTELQYYVTQEEGTERPFNNKYWDNKEAGIYVDIVTGEPLFSSTDKYKSGTGW
CHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
PSFTRPINPRYIVEKTDFKLVYPRTEIRSKFGDSHIGHVFKDGPKPTGLRYCMNSAAMEF
CCCCCCCCCCEEEEECCEEEECCHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHEE
VPVNKMASLGYGDYLFLFDK
EECHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MKKVSKLLVGFSFTLTVLFILLSKTGAADTMDKMNASGKTDIATLAGGCFWCTESDLEQL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHCCCEEECCCHHHHHC
PGVLDVVSGYSGGDLENPTYRQVSSGKSGHIEVIEVKYDPAVVNYEQVLDYFFRHIDPTD
CCHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHCCCCC
AKGSFVDRGPQYRPAIFYHNAEQKQIAEQFMMEIDKAMIYPKPLKTELIEFEKFYPAESY
CCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
HQDYYKKSSLKYKYYRYASGRDKYLDEVFGDDRKDNPKTLRELINEKELVSKVKVYEKPS
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DKEIKAKLTELQYYVTQEEGTERPFNNKYWDNKEAGIYVDIVTGEPLFSSTDKYKSGTGW
CHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
PSFTRPINPRYIVEKTDFKLVYPRTEIRSKFGDSHIGHVFKDGPKPTGLRYCMNSAAMEF
CCCCCCCCCCEEEEECCEEEECCHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHEE
VPVNKMASLGYGDYLFLFDK
EECHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]