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The map label for this gene is mdtL [H]

Identifier: 156977844

GI number: 156977844

Start: 1773673

End: 1773942

Strand: Direct

Name: mdtL [H]

Synonym: VIBHAR_06632

Alternate gene names: 156977844

Gene position: 1773673-1773942 (Clockwise)

Preceding gene: 156977842

Following gene: 156977845

Centisome position: 80.47

GC content: 42.22

Gene sequence:

>270_bases
ATGGAAATACCTACGGTCGTAATTCCCACTCGCAGGCAAACGTTTCACATTTTATTATCCTCGCCAATTGTCAGTGAGGT
TATTATGTTCCGTTTTCTGCTTTGTAGTTTTTCCCTTGTATTACTCTATTCTACCGCGATTGATCTTTACCTTGTAGGTT
TGCCACAAATTGCAGCCGATTTACACACCAACGAGTCACAATTACATATCGCGTTCTCTATCTATCTCGCGGGAATGGCA
GCCAAATTGCGGAAAAACGCAGCGATATAG

Upstream 100 bases:

>100_bases
GCTCAATGGTTTGGGCGTGTCGACATGGCGTGTACTTTTCAATGGTAATCATGGTCATCCTTGTTGAATTTCCGTTCGAT
TTATACGGAGTATGTCGTAA

Downstream 100 bases:

>100_bases
CACCAAAAGGCGTACGCTTTGATCTGACCATTGAATCCCCGTTAGTGCTGACGATTCTTGATGAGCTTCTTATCGCAATC
CACCAGCGTTACCCGGATGC

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 89; Mature: 89

Protein sequence:

>89_residues
MEIPTVVIPTRRQTFHILLSSPIVSEVIMFRFLLCSFSLVLLYSTAIDLYLVGLPQIAADLHTNESQLHIAFSIYLAGMA
AKLRKNAAI

Sequences:

>Translated_89_residues
MEIPTVVIPTRRQTFHILLSSPIVSEVIMFRFLLCSFSLVLLYSTAIDLYLVGLPQIAADLHTNESQLHIAFSIYLAGMA
AKLRKNAAI
>Mature_89_residues
MEIPTVVIPTRRQTFHILLSSPIVSEVIMFRFLLCSFSLVLLYSTAIDLYLVGLPQIAADLHTNESQLHIAFSIYLAGMA
AKLRKNAAI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=55, Percent_Identity=72.7272727272727, Blast_Score=89, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 9918; Mature: 9918

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIPTVVIPTRRQTFHILLSSPIVSEVIMFRFLLCSFSLVLLYSTAIDLYLVGLPQIAAD
CCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LHTNESQLHIAFSIYLAGMAAKLRKNAAI
CCCCCCCEEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIPTVVIPTRRQTFHILLSSPIVSEVIMFRFLLCSFSLVLLYSTAIDLYLVGLPQIAAD
CCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LHTNESQLHIAFSIYLAGMAAKLRKNAAI
CCCCCCCEEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]