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The map label for this gene is moeA [H]

Identifier: 156977449

GI number: 156977449

Start: 1417034

End: 1418242

Strand: Direct

Name: moeA [H]

Synonym: VIBHAR_06236

Alternate gene names: 156977449

Gene position: 1417034-1418242 (Clockwise)

Preceding gene: 156977447

Following gene: 156977450

Centisome position: 64.29

GC content: 47.15

Gene sequence:

>1209_bases
ATGCCAATTGAAGAAGCGATGGACAAAATGCTATCGCGAATCAAACCTATCCAAACTACGCTTTCTCTTCCACTTGCTGA
AGCACTCGGTTTTGTACTGGCAGAAGACATCTTGTCTCCTATTCACGTACCGCCATTCGATAACTCAGCAATGGATGGTT
ACGCAATTCGCATTCAAGATCTTGAGTCATCTTCTGTATTGCCTCTAGCAGGTAAATCATTTGCAGGACAACCTTTTGAA
GGTGAATGGCCACAAGGTACCTGTGTTCGCATTATGACTGGCGCAAAAATCCCTGAAGGTTGCGACGCCGTTATCATGCA
AGAAAACACAGAAGTGACGGATGCTGGCATTCAGTTCAACCAAACTGACGTGAAGCCGCAAAATAACATCCGCCCAACAG
GTGACGACATCAAGCAAGGCGACATCGTGCTTGCACAAGATGCGCGTTTAACACCTCGCGATATTCCGATGATTGCGTCT
CTTGGTGTAAGCCATGTGACGGTAGTGCGTAAACCAAAAGTTGCTTTCTTCTCTACTGGTGATGAGCTTAAACCACTAGG
CGAACCATTAGACGAAGGTCAGATCTACGACAGCAACCGTTACGGTATTAAACCGCTTATCGAGAACTTCGGTTGTGAGG
CGATTGATCTTGGCATCATTCCAGATTGCCCAGAGACTCTGAAAGCAACTTTTGAACAAGCGCAAACGTTGGCTGATGTC
GTTGTTACCTCTGGTGGTGTTAGCGTCGGCGAAGCGGATTACACCAAGGACATTCTTGAAGAGCTTGGTGAAATTGGTTT
CTGGAAGCTAGCAATCAAGCCGGGTAAACCTTTCGCATTTGGTAAGCTAAGTACAGCTTGGTTCTGTGGTCTGCCGGGTA
ACCCGGTTTCCGCCGTACTTACCATGTACGTACTTGTTCAACCAATGCTTGCAAAACTTGCAGGCCATACAGAATGGAAA
GCACCTGAGTCTATTCCTGCAACAACCAAAACCGCCTTTAAGAAAGCGCCAGGTCGTACCGATTACCAACGTGGCATCTA
TACATTGGAAGATGGCAAGTTTGTAGTTGAAACAACCGGAAACCAAAGCTCTGGTGCATTCCGCTCCATGAGCCTAGCGA
ACTGTTTTGTTGTGTTAGAGCGCGAGCGCGGCCGTGTGGAAGTAGGTGAAACGGTTCAGATCCAACTATTCAACTCAACC
CTATACTAG

Upstream 100 bases:

>100_bases
AGGTGGACATTCTTACTCGGTCCCCTTTTTATGGTAAAGTTGCCACAAAACAAAAGAACACAGGATTTTCTCAATGGGCT
GCTGCGACGCACCTGGCTTG

Downstream 100 bases:

>100_bases
GAAATCGTTGTGGATATTCTTTCCGATCAGGAAATGCTACGTTACAACCGCCAAATCATTCTTCGTCAATTTGACTTTGA
AGGGCAAGAGGCGCTCAAAC

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MPIEEAMDKMLSRIKPIQTTLSLPLAEALGFVLAEDILSPIHVPPFDNSAMDGYAIRIQDLESSSVLPLAGKSFAGQPFE
GEWPQGTCVRIMTGAKIPEGCDAVIMQENTEVTDAGIQFNQTDVKPQNNIRPTGDDIKQGDIVLAQDARLTPRDIPMIAS
LGVSHVTVVRKPKVAFFSTGDELKPLGEPLDEGQIYDSNRYGIKPLIENFGCEAIDLGIIPDCPETLKATFEQAQTLADV
VVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGKLSTAWFCGLPGNPVSAVLTMYVLVQPMLAKLAGHTEWK
APESIPATTKTAFKKAPGRTDYQRGIYTLEDGKFVVETTGNQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNST
LY

Sequences:

>Translated_402_residues
MPIEEAMDKMLSRIKPIQTTLSLPLAEALGFVLAEDILSPIHVPPFDNSAMDGYAIRIQDLESSSVLPLAGKSFAGQPFE
GEWPQGTCVRIMTGAKIPEGCDAVIMQENTEVTDAGIQFNQTDVKPQNNIRPTGDDIKQGDIVLAQDARLTPRDIPMIAS
LGVSHVTVVRKPKVAFFSTGDELKPLGEPLDEGQIYDSNRYGIKPLIENFGCEAIDLGIIPDCPETLKATFEQAQTLADV
VVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGKLSTAWFCGLPGNPVSAVLTMYVLVQPMLAKLAGHTEWK
APESIPATTKTAFKKAPGRTDYQRGIYTLEDGKFVVETTGNQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNST
LY
>Mature_401_residues
PIEEAMDKMLSRIKPIQTTLSLPLAEALGFVLAEDILSPIHVPPFDNSAMDGYAIRIQDLESSSVLPLAGKSFAGQPFEG
EWPQGTCVRIMTGAKIPEGCDAVIMQENTEVTDAGIQFNQTDVKPQNNIRPTGDDIKQGDIVLAQDARLTPRDIPMIASL
GVSHVTVVRKPKVAFFSTGDELKPLGEPLDEGQIYDSNRYGIKPLIENFGCEAIDLGIIPDCPETLKATFEQAQTLADVV
VTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGKLSTAWFCGLPGNPVSAVLTMYVLVQPMLAKLAGHTEWKA
PESIPATTKTAFKKAPGRTDYQRGIYTLEDGKFVVETTGNQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNSTL
Y

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=393, Percent_Identity=36.6412213740458, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI66932975, Length=393, Percent_Identity=36.6412213740458, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1787049, Length=400, Percent_Identity=58.25, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI25147659, Length=303, Percent_Identity=34.6534653465347, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=334, Percent_Identity=27.5449101796407, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136978, Length=379, Percent_Identity=29.5514511873351, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24638841, Length=379, Percent_Identity=29.5514511873351, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43647; Mature: 43516

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIEEAMDKMLSRIKPIQTTLSLPLAEALGFVLAEDILSPIHVPPFDNSAMDGYAIRIQD
CCHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEE
LESSSVLPLAGKSFAGQPFEGEWPQGTCVRIMTGAKIPEGCDAVIMQENTEVTDAGIQFN
CCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCEEEC
QTDVKPQNNIRPTGDDIKQGDIVLAQDARLTPRDIPMIASLGVSHVTVVRKPKVAFFSTG
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCEEEEECC
DELKPLGEPLDEGQIYDSNRYGIKPLIENFGCEAIDLGIIPDCPETLKATFEQAQTLADV
CCCCCCCCCCCCCEEECCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
VVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGKLSTAWFCGLPGNPVSAVL
HHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCEEEECCCCCHHHHHH
TMYVLVQPMLAKLAGHTEWKAPESIPATTKTAFKKAPGRTDYQRGIYTLEDGKFVVETTG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCCEEEECCEEEEEECC
NQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNSTLY
CCCCCCHHHHHHEEEEEEEECCCCCEEECCEEEEEEECCCCC
>Mature Secondary Structure 
PIEEAMDKMLSRIKPIQTTLSLPLAEALGFVLAEDILSPIHVPPFDNSAMDGYAIRIQD
CHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEE
LESSSVLPLAGKSFAGQPFEGEWPQGTCVRIMTGAKIPEGCDAVIMQENTEVTDAGIQFN
CCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCEEEC
QTDVKPQNNIRPTGDDIKQGDIVLAQDARLTPRDIPMIASLGVSHVTVVRKPKVAFFSTG
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCEEEEECC
DELKPLGEPLDEGQIYDSNRYGIKPLIENFGCEAIDLGIIPDCPETLKATFEQAQTLADV
CCCCCCCCCCCCCEEECCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
VVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGKLSTAWFCGLPGNPVSAVL
HHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEECCCCCEEEECCCCCHHHHHH
TMYVLVQPMLAKLAGHTEWKAPESIPATTKTAFKKAPGRTDYQRGIYTLEDGKFVVETTG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCCEEEECCEEEEEECC
NQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNSTLY
CCCCCCHHHHHHEEEEEEEECCCCCEEECCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]