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The map label for this gene is macA [H]

Identifier: 156977179

GI number: 156977179

Start: 1153957

End: 1155030

Strand: Reverse

Name: macA [H]

Synonym: VIBHAR_05965

Alternate gene names: 156977179

Gene position: 1155030-1153957 (Counterclockwise)

Preceding gene: 156977181

Following gene: 156977178

Centisome position: 52.41

GC content: 47.67

Gene sequence:

>1074_bases
GTGCGAAAACAATACTTAAAGCGCACATTTGTCGGAGCAGCGGTGGCATTGAGCCTCGCCACGATGCTGACAGGGTGTAA
CAAAGCCGTATCAGAGCCGTCCGAGCCATTAATCAAACCGGTGAAATTGCTTGCTGTTAATGATTTAACGGTTGCCGATT
CCGATGCATTCCTTGCACAAATAGATGCAACCTACAGAGCGCAACTTTCGTTTCAGGTTGGTGGCGAAATTGAGAAGTTG
ATCGTACGAATGGGTGAAGAAGTGAAGCAGGGTGATGTACTTGCAACGCTAGACCCAAAAGATTTGCAGCTGGCGCTTGA
TGCATCACAAGCGCAGTACGCATTAGCAAAAACGCAATGGGAACGCTCAAAAAGCTTGTACAACAAGAAGCTGATCAGCG
CGGATAGCTACGACCAGCAAGAAACCCAATACAAAGCGGCACTGGCAAGTTTAGAGCAAGCAAAAACCGACCTGAGCTAC
ACAGAGATTCATGCACCGTTTGATGGTGTGGTGTCTTATACCTACGTGAAGCCTTATCAAGTGGTGGCTGCTAAGCAAGA
AATCCTAAACCTAATCGACAACACCACGTTGGACGTGTCGTTCACTCTTCCGGTGACTTACGCCGAAGCGGTATCGTTGA
ACTCACTTAAAGACGCAGAGATGTGGGTGACGATGGACAGCGAACCTAACAAACGCATCCAAGGCAAATTCAAAGAAATC
TCTACTCAACCAAATGCCGACACCAACAGCTACAAAGCGATCGTGACGATTACTCGTCCTTCTGATCGTAACTTGCTAAC
GGGCATGACAGGCCAAGTACACATTGCGAAGCAAAACGTATCGAACGCGATGATGCTACCAAATGCGGCTTGGGTATCGA
AAGACGCGGCTCATGGTGAAGTTTGGGTAATGGACAGCGATACACAGCAAGTGAATAAAGTGACCTTGTCACTAAATGCG
AACGGTGCTGTTGAGTCGGGTCTAGACAAGAATGATTACGTTGTTATTGCAGGTGTTGAACGCCTAGTGGAAGGCCAAGT
AGTGAAAGCTTGGGTTCGTGAGGAAGGTATCTAA

Upstream 100 bases:

>100_bases
TAATTATTTTATTATCCAAATGGAAAATATGTTGATCATTTTTTTGTGAATAATATACTGCACGACTGTGTAGTAAATAT
AAAGTCGATGGAGAAAGCCA

Downstream 100 bases:

>100_bases
TGAAACGTTCATTATTCACAGTATCGGCTATCGCACTGGCGGTACTCACCGGTTGTAACAGCACAGACGAAGTCACCGCA
GAGCAGCCTTTGTATGTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRKQYLKRTFVGAAVALSLATMLTGCNKAVSEPSEPLIKPVKLLAVNDLTVADSDAFLAQIDATYRAQLSFQVGGEIEKL
IVRMGEEVKQGDVLATLDPKDLQLALDASQAQYALAKTQWERSKSLYNKKLISADSYDQQETQYKAALASLEQAKTDLSY
TEIHAPFDGVVSYTYVKPYQVVAAKQEILNLIDNTTLDVSFTLPVTYAEAVSLNSLKDAEMWVTMDSEPNKRIQGKFKEI
STQPNADTNSYKAIVTITRPSDRNLLTGMTGQVHIAKQNVSNAMMLPNAAWVSKDAAHGEVWVMDSDTQQVNKVTLSLNA
NGAVESGLDKNDYVVIAGVERLVEGQVVKAWVREEGI

Sequences:

>Translated_357_residues
MRKQYLKRTFVGAAVALSLATMLTGCNKAVSEPSEPLIKPVKLLAVNDLTVADSDAFLAQIDATYRAQLSFQVGGEIEKL
IVRMGEEVKQGDVLATLDPKDLQLALDASQAQYALAKTQWERSKSLYNKKLISADSYDQQETQYKAALASLEQAKTDLSY
TEIHAPFDGVVSYTYVKPYQVVAAKQEILNLIDNTTLDVSFTLPVTYAEAVSLNSLKDAEMWVTMDSEPNKRIQGKFKEI
STQPNADTNSYKAIVTITRPSDRNLLTGMTGQVHIAKQNVSNAMMLPNAAWVSKDAAHGEVWVMDSDTQQVNKVTLSLNA
NGAVESGLDKNDYVVIAGVERLVEGQVVKAWVREEGI
>Mature_357_residues
MRKQYLKRTFVGAAVALSLATMLTGCNKAVSEPSEPLIKPVKLLAVNDLTVADSDAFLAQIDATYRAQLSFQVGGEIEKL
IVRMGEEVKQGDVLATLDPKDLQLALDASQAQYALAKTQWERSKSLYNKKLISADSYDQQETQYKAALASLEQAKTDLSY
TEIHAPFDGVVSYTYVKPYQVVAAKQEILNLIDNTTLDVSFTLPVTYAEAVSLNSLKDAEMWVTMDSEPNKRIQGKFKEI
STQPNADTNSYKAIVTITRPSDRNLLTGMTGQVHIAKQNVSNAMMLPNAAWVSKDAAHGEVWVMDSDTQQVNKVTLSLNA
NGAVESGLDKNDYVVIAGVERLVEGQVVKAWVREEGI

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=315, Percent_Identity=26.984126984127, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082036, Length=319, Percent_Identity=26.6457680250784, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789929, Length=370, Percent_Identity=22.972972972973, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39216; Mature: 39216

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKQYLKRTFVGAAVALSLATMLTGCNKAVSEPSEPLIKPVKLLAVNDLTVADSDAFLAQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHCCEEEEEEECEEEECCCCEEEE
IDATYRAQLSFQVGGEIEKLIVRMGEEVKQGDVLATLDPKDLQLALDASQAQYALAKTQW
ECCEEEEEEEEEECCHHHHHHHHHCCHHCCCCEEEEECCCCEEEEEECCHHHHHHHHHHH
ERSKSLYNKKLISADSYDQQETQYKAALASLEQAKTDLSYTEIHAPFDGVVSYTYVKPYQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHH
VVAAKQEILNLIDNTTLDVSFTLPVTYAEAVSLNSLKDAEMWVTMDSEPNKRIQGKFKEI
HHHHHHHHHHHHCCCEEEEEEEECEEEHHHHCCCCCCCCEEEEEECCCCCHHHHCHHHHC
STQPNADTNSYKAIVTITRPSDRNLLTGMTGQVHIAKQNVSNAMMLPNAAWVSKDAAHGE
CCCCCCCCCCEEEEEEEECCCCCCEEECCCCEEEEEECCCCCEEECCCCHHCCCCCCCCE
VWVMDSDTQQVNKVTLSLNANGAVESGLDKNDYVVIAGVERLVEGQVVKAWVREEGI
EEEEECCCCCEEEEEEEEECCCCHHCCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MRKQYLKRTFVGAAVALSLATMLTGCNKAVSEPSEPLIKPVKLLAVNDLTVADSDAFLAQ
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHCCEEEEEEECEEEECCCCEEEE
IDATYRAQLSFQVGGEIEKLIVRMGEEVKQGDVLATLDPKDLQLALDASQAQYALAKTQW
ECCEEEEEEEEEECCHHHHHHHHHCCHHCCCCEEEEECCCCEEEEEECCHHHHHHHHHHH
ERSKSLYNKKLISADSYDQQETQYKAALASLEQAKTDLSYTEIHAPFDGVVSYTYVKPYQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHH
VVAAKQEILNLIDNTTLDVSFTLPVTYAEAVSLNSLKDAEMWVTMDSEPNKRIQGKFKEI
HHHHHHHHHHHHCCCEEEEEEEECEEEHHHHCCCCCCCCEEEEEECCCCCHHHHCHHHHC
STQPNADTNSYKAIVTITRPSDRNLLTGMTGQVHIAKQNVSNAMMLPNAAWVSKDAAHGE
CCCCCCCCCCEEEEEEEECCCCCCEEECCCCEEEEEECCCCCEEECCCCHHCCCCCCCCE
VWVMDSDTQQVNKVTLSLNANGAVESGLDKNDYVVIAGVERLVEGQVVKAWVREEGI
EEEEECCCCCEEEEEEEEECCCCHHCCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]