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The map label for this gene is pntB [H]

Identifier: 156976949

GI number: 156976949

Start: 936499

End: 937893

Strand: Direct

Name: pntB [H]

Synonym: VIBHAR_05734

Alternate gene names: 156976949

Gene position: 936499-937893 (Clockwise)

Preceding gene: 156976948

Following gene: 156976950

Centisome position: 42.49

GC content: 48.24

Gene sequence:

>1395_bases
ATGTCTGCAGGATTAGTACAAGCGGCATACATTATTGCTGCGCTATTTTTCATATTAAGTCTCGCGGGACTTTCTAAACA
AGAATCAGCAAGAAAGGGTAACTACTACGGTATTGCGGGTATGGCGATTGCGCTTATTGCGACAATCTTTAGCCCGAATG
CAGAAGGGTTCGTTTGGGTCATCATCGCGATGGTCATCGGTGGTAGCATCGGTATCCACTACGCAAAGAAAGTAGAAATG
ACTCAAATGCCAGAACTGGTTGCGATCCTACACAGCTTTGTAGGTATGGCTGCAGTTTTGGTAGGTTACAACAGCTACCT
TGAGCCACCAGCACCAGTTTCAACTGACCTTGCTGGTATTCACGCCGAGCACGTGATTCACCTGGTGGAAGTCTTCCTTG
GCGTGTTCATCGGTGCGGTAACCTTTACGGGTTCAGTCGTTGCTTTCGGTAAGCTACGCGGCACGATCTCATCTTCGCCA
CTTAACTTGCCTCACAAGCACAAAATGAACCTTGCGGCGATCGTCGTTTCTACGCTTCTTATGATTTACTTCGTAAAAGC
GGACGGCAGCATGTTCGCACTGATCGTAATGACGCTGATTGCATTCGCATTCGGTTACCACTTAGTGGCGTCTATCGGTG
GTGCAGATATGCCAGTTGTGGTTTCAATGCTGAACTCATACTCAGGTTGGGCAGCGGCGGCGGCAGGTTTCATGCTTGCA
AACGACCTATTGATCGTGACAGGTGCACTAGTTGGTTCTTCGGGTGCGATCCTTTCTTACATCATGTGTAAAGCGATGAA
CCGCTCGTTTATCAGCGTTATCGCTGGCGGCTTCGGTCAAGAAGTTGTGATTTCAAGTGATGAAGAGCAGGGCGAACACC
GCGAAACGTCAACTGAAGAAGTTGCAGAAATGCTGAAGAACTCAAAATCAGTGGTCATCACACCGGGATACGGCATGGCA
GTAGCTCAAGCACAATACCCAGTGCATGAGATCACGGAGACATTGCGTAATCAGGGCATTGAAGTTCGCTTCGGTATTCA
CCCTGTTGCTGGCCGTTTACCAGGTCACATGAACGTTCTACTGGCAGAAGCAAAAGTCCCTTACGATATCGTACTAGAGA
TGGACGAGATCAACGATGACTTCCCAGAGACAGATACCGTTCTGGTTATCGGCGCGAACGATACAGTGAACCCAGCAGCG
CTTGAAGATCCAAACAGCCCAATCGCAGGCATGCCTGTATTAGAAGTTTGGAACGCGCAAAACGTAGTCGTATTCAAGCG
TTCAATGAATACCGGTTACGCTGGCGTACAAAACCCACTGTTCTTTAAAGAAAACACCTCAATGCTATTCGGTGATGCGA
AAGAGAGCGTCGAGGCAATTTTCAAAGCATTGTAA

Upstream 100 bases:

>100_bases
CATTGCTGTACTCATTGCAAGCATAAACATCTTTGGTGGCTTTACCGTGACCAAACGTATGCTTGAAATGTTCCGCAAAG
ATAAATAATAGGAGTGACCA

Downstream 100 bases:

>100_bases
AATATTTGCTCTAAAACTAACCAAGGCCAGCATTCGCTGGCCTTTTTTGTGGGGCTTCAATGTTATAGTACTGCAAATCC
TTGAGCCGCCTAATGTCATT

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSAGLVQAAYIIAALFFILSLAGLSKQESARKGNYYGIAGMAIALIATIFSPNAEGFVWVIIAMVIGGSIGIHYAKKVEM
TQMPELVAILHSFVGMAAVLVGYNSYLEPPAPVSTDLAGIHAEHVIHLVEVFLGVFIGAVTFTGSVVAFGKLRGTISSSP
LNLPHKHKMNLAAIVVSTLLMIYFVKADGSMFALIVMTLIAFAFGYHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLA
NDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGQEVVISSDEEQGEHRETSTEEVAEMLKNSKSVVITPGYGMA
VAQAQYPVHEITETLRNQGIEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDTVLVIGANDTVNPAA
LEDPNSPIAGMPVLEVWNAQNVVVFKRSMNTGYAGVQNPLFFKENTSMLFGDAKESVEAIFKAL

Sequences:

>Translated_464_residues
MSAGLVQAAYIIAALFFILSLAGLSKQESARKGNYYGIAGMAIALIATIFSPNAEGFVWVIIAMVIGGSIGIHYAKKVEM
TQMPELVAILHSFVGMAAVLVGYNSYLEPPAPVSTDLAGIHAEHVIHLVEVFLGVFIGAVTFTGSVVAFGKLRGTISSSP
LNLPHKHKMNLAAIVVSTLLMIYFVKADGSMFALIVMTLIAFAFGYHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLA
NDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGQEVVISSDEEQGEHRETSTEEVAEMLKNSKSVVITPGYGMA
VAQAQYPVHEITETLRNQGIEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDTVLVIGANDTVNPAA
LEDPNSPIAGMPVLEVWNAQNVVVFKRSMNTGYAGVQNPLFFKENTSMLFGDAKESVEAIFKAL
>Mature_463_residues
SAGLVQAAYIIAALFFILSLAGLSKQESARKGNYYGIAGMAIALIATIFSPNAEGFVWVIIAMVIGGSIGIHYAKKVEMT
QMPELVAILHSFVGMAAVLVGYNSYLEPPAPVSTDLAGIHAEHVIHLVEVFLGVFIGAVTFTGSVVAFGKLRGTISSSPL
NLPHKHKMNLAAIVVSTLLMIYFVKADGSMFALIVMTLIAFAFGYHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLAN
DLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGQEVVISSDEEQGEHRETSTEEVAEMLKNSKSVVITPGYGMAV
AQAQYPVHEITETLRNQGIEVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPETDTVLVIGANDTVNPAAL
EDPNSPIAGMPVLEVWNAQNVVVFKRSMNTGYAGVQNPLFFKENTSMLFGDAKESVEAIFKAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=462, Percent_Identity=50.4329004329004, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI122939153, Length=462, Percent_Identity=50.4329004329004, Blast_Score=444, Evalue=1e-125,
Organism=Escherichia coli, GI1787886, Length=468, Percent_Identity=77.5641025641026, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=461, Percent_Identity=47.7223427331887, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49357; Mature: 49226

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEEEEECCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
SAGLVQAAYIIAALFFILSLAGLSKQESARKGNYYGIAGMAIALIATIFSPNAEGFVWV
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCHHHH
IIAMVIGGSIGIHYAKKVEMTQMPELVAILHSFVGMAAVLVGYNSYLEPPAPVSTDLAGI
HHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
HAEHVIHLVEVFLGVFIGAVTFTGSVVAFGKLRGTISSSPLNLPHKHKMNLAAIVVSTLL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHH
MIYFVKADGSMFALIVMTLIAFAFGYHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLA
HHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
NDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGQEVVISSDEEQGEHRETSTEE
CCHHHEEHHHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHH
VAEMLKNSKSVVITPGYGMAVAQAQYPVHEITETLRNQGIEVRFGIHPVAGRLPGHMNVL
HHHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEECCCHHCCCCCCCCEEE
LAEAKVPYDIVLEMDEINDDFPETDTVLVIGANDTVNPAALEDPNSPIAGMPVLEVWNAQ
EECCCCCEEEEEEEHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCC
NVVVFKRSMNTGYAGVQNPLFFKENTSMLFGDAKESVEAIFKAL
CEEEEEECCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]