Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 156976780

GI number: 156976780

Start: 759424

End: 760518

Strand: Reverse

Name: pdhA [H]

Synonym: VIBHAR_05555

Alternate gene names: 156976780

Gene position: 760518-759424 (Counterclockwise)

Preceding gene: 156976782

Following gene: 156976779

Centisome position: 34.51

GC content: 50.32

Gene sequence:

>1095_bases
ATGAACGTTCAGGCATTACCCATGCATCGGTTTATCGACCATGATGGGAACCTCGTCAGCCAACTACCCAACTGGGCTGA
CCTAGAAGTACTGGTCGGTTTTTACCAAGACATGGTATTAACTCGCACCTACGATAACAAAGCCGTTGCCCTGCAACGCA
CCGGCAAATTAGGCACCTACCCTTCACACCTTGGCTCGGAAGCCATTGGGATAGCGGTTGGCAGAGCACTAAAAGCCAGT
GATGTCTTTGTTCCTTACTATCGCGACATGCCAGCGATGTGGTGTCGTGGTATTGGTATGGAAAAGAACCTGCAATACTG
GGGAGGCGATGAACGCGGTAGCGACTTCGCACCAGAAGGCAGCCCATTCCCTAGCCGAGATTTACCTTTCTGTGTTCCTA
TCGCCACCCAATGTACTCATGCGGTGGGCGTTGCATCTGCACTGAAGATTCAAGGTAATCATGAGGCAGCTTTAGTGATG
TGCGGTGACGGCGCGACATCTAAAGGTGACTTCCTCGAATCCGTCAACTGTGCGGGCGCTTGGAACATTCCATTAGTCTT
TATAGTGAACAACAACCAGTGGGCCATCTCCGTACCGCGCACCTTACAATGCGCCGCGGAGTTTTTATCAGAAAAAGCCA
AAGGTGCAGGTATTCCTGGCATTACTGTAGATGGTAATGACATCGTTGCGGTATTTGACGCAACAATGACTGCCCTCGAC
CGAGCCAGAAAAGGCAAAGGCGCGACGTTAATAGAAGCCGTAAGTTACCGCTTGAGCGATCACACCACTGCCGACGACGC
AACCCGTTATCGTAATGAGGATGAAGTTCAAACGGCTTGGCAATATGAGCCCGTCCGTCGCCTTAAAGCCTTTCTCACCA
ATCAAGGCGTTTGGAGTAACGAGAAAGAGCAAGAGTGGCAAGCCCACTGCAAAGAACAAGTTGAACTCGCCGTTGAACGT
TATCTCAATATGCCGAATCAAGCGCCTGAAACGGGCTTTGACTTCCTTTATGAATCCCTACCCCAAGAGCTTCATGCACA
AAGAGATGAACTGATCAACAAAGCAATGCGAATGCAGGGAGGGAAACATGGCTGA

Upstream 100 bases:

>100_bases
CCTTTTGCGCTGATATCAAAGACTGAGTACCCATACAGACTTTGATTTAATAATAAGCAGCTGCAGTCCAAAAGACCCGC
AGCTTCAAAAGGAGCTTGAG

Downstream 100 bases:

>100_bases
ACTGACGTTAGTTGAAGCAGTGAACCTCGCACTGCACCATGAAATGGAACGCGACCCGAATGTCATCGTCCTTGGCGAAG
ATGTGGGTGACAACGGCGGT

Product: pyruvate dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNVQALPMHRFIDHDGNLVSQLPNWADLEVLVGFYQDMVLTRTYDNKAVALQRTGKLGTYPSHLGSEAIGIAVGRALKAS
DVFVPYYRDMPAMWCRGIGMEKNLQYWGGDERGSDFAPEGSPFPSRDLPFCVPIATQCTHAVGVASALKIQGNHEAALVM
CGDGATSKGDFLESVNCAGAWNIPLVFIVNNNQWAISVPRTLQCAAEFLSEKAKGAGIPGITVDGNDIVAVFDATMTALD
RARKGKGATLIEAVSYRLSDHTTADDATRYRNEDEVQTAWQYEPVRRLKAFLTNQGVWSNEKEQEWQAHCKEQVELAVER
YLNMPNQAPETGFDFLYESLPQELHAQRDELINKAMRMQGGKHG

Sequences:

>Translated_364_residues
MNVQALPMHRFIDHDGNLVSQLPNWADLEVLVGFYQDMVLTRTYDNKAVALQRTGKLGTYPSHLGSEAIGIAVGRALKAS
DVFVPYYRDMPAMWCRGIGMEKNLQYWGGDERGSDFAPEGSPFPSRDLPFCVPIATQCTHAVGVASALKIQGNHEAALVM
CGDGATSKGDFLESVNCAGAWNIPLVFIVNNNQWAISVPRTLQCAAEFLSEKAKGAGIPGITVDGNDIVAVFDATMTALD
RARKGKGATLIEAVSYRLSDHTTADDATRYRNEDEVQTAWQYEPVRRLKAFLTNQGVWSNEKEQEWQAHCKEQVELAVER
YLNMPNQAPETGFDFLYESLPQELHAQRDELINKAMRMQGGKHG
>Mature_364_residues
MNVQALPMHRFIDHDGNLVSQLPNWADLEVLVGFYQDMVLTRTYDNKAVALQRTGKLGTYPSHLGSEAIGIAVGRALKAS
DVFVPYYRDMPAMWCRGIGMEKNLQYWGGDERGSDFAPEGSPFPSRDLPFCVPIATQCTHAVGVASALKIQGNHEAALVM
CGDGATSKGDFLESVNCAGAWNIPLVFIVNNNQWAISVPRTLQCAAEFLSEKAKGAGIPGITVDGNDIVAVFDATMTALD
RARKGKGATLIEAVSYRLSDHTTADDATRYRNEDEVQTAWQYEPVRRLKAFLTNQGVWSNEKEQEWQAHCKEQVELAVER
YLNMPNQAPETGFDFLYESLPQELHAQRDELINKAMRMQGGKHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=360, Percent_Identity=31.3888888888889, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI258645172, Length=360, Percent_Identity=31.3888888888889, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4885543, Length=291, Percent_Identity=27.8350515463918, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291084744, Length=187, Percent_Identity=32.0855614973262, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4505685, Length=187, Percent_Identity=32.0855614973262, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI291084742, Length=187, Percent_Identity=32.0855614973262, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI291084757, Length=160, Percent_Identity=31.25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563357, Length=361, Percent_Identity=34.3490304709141, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI86563355, Length=361, Percent_Identity=34.3490304709141, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=26.0736196319018, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=26.0736196319018, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=27.5541795665635, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21355903, Length=360, Percent_Identity=30.8333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639748, Length=287, Percent_Identity=25.0871080139373, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24639740, Length=297, Percent_Identity=24.9158249158249, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639744, Length=297, Percent_Identity=24.9158249158249, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571106, Length=297, Percent_Identity=24.9158249158249, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639746, Length=258, Percent_Identity=25.5813953488372, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40287; Mature: 40287

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVQALPMHRFIDHDGNLVSQLPNWADLEVLVGFYQDMVLTRTYDNKAVALQRTGKLGTY
CCCCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCC
PSHLGSEAIGIAVGRALKASDVFVPYYRDMPAMWCRGIGMEKNLQYWGGDERGSDFAPEG
HHHHCCHHHHHHHHCHHCCCCEEECHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SPFPSRDLPFCVPIATQCTHAVGVASALKIQGNHEAALVMCGDGATSKGDFLESVNCAGA
CCCCCCCCCEEEEHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCC
WNIPLVFIVNNNQWAISVPRTLQCAAEFLSEKAKGAGIPGITVDGNDIVAVFDATMTALD
CCCCEEEEEECCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEHHHHHHHHH
RARKGKGATLIEAVSYRLSDHTTADDATRYRNEDEVQTAWQYEPVRRLKAFLTNQGVWSN
HHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EKEQEWQAHCKEQVELAVERYLNMPNQAPETGFDFLYESLPQELHAQRDELINKAMRMQG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GKHG
CCCC
>Mature Secondary Structure
MNVQALPMHRFIDHDGNLVSQLPNWADLEVLVGFYQDMVLTRTYDNKAVALQRTGKLGTY
CCCCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCC
PSHLGSEAIGIAVGRALKASDVFVPYYRDMPAMWCRGIGMEKNLQYWGGDERGSDFAPEG
HHHHCCHHHHHHHHCHHCCCCEEECHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SPFPSRDLPFCVPIATQCTHAVGVASALKIQGNHEAALVMCGDGATSKGDFLESVNCAGA
CCCCCCCCCEEEEHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCHHHHHCCCCCC
WNIPLVFIVNNNQWAISVPRTLQCAAEFLSEKAKGAGIPGITVDGNDIVAVFDATMTALD
CCCCEEEEEECCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEHHHHHHHHH
RARKGKGATLIEAVSYRLSDHTTADDATRYRNEDEVQTAWQYEPVRRLKAFLTNQGVWSN
HHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EKEQEWQAHCKEQVELAVERYLNMPNQAPETGFDFLYESLPQELHAQRDELINKAMRMQG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GKHG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA