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The map label for this gene is acdA [H]

Identifier: 156976709

GI number: 156976709

Start: 696943

End: 698097

Strand: Direct

Name: acdA [H]

Synonym: VIBHAR_05484

Alternate gene names: 156976709

Gene position: 696943-698097 (Clockwise)

Preceding gene: 156976708

Following gene: 156976710

Centisome position: 31.62

GC content: 51.26

Gene sequence:

>1155_bases
ATGGATTTTGAACTCAACGAAGATCAACGTATGTTTGCCGACACCGCGCAGCAGTTTGCGGCAGAGCGTTTAGCGCCAAT
GGCAGCAGGGTGGGATGAGAAACAAATCTTCCCCAAAGACATTCTACGAGAGGCAGGAGAGCTTGGCTTCTTGAGCCTCT
ACACACCAGAAGAACAAGGCGGTTTGGGCTTAAGCCGTTTGGATGCGTCTATAATCTTCGAGCAACTCTCGATGGGGTGT
ACGTCGACCACCGCATTTATGACCATTCACAACATGGTGACTTGGATGGTCGCGAGCTTTGCTAGCGAAGAGGTAAAAGA
CGCGTTCTGCCCCAAACTTATTACGGGTGACTTTCTCGGTTCTTACTGTTTAACCGAGCCAAACGCAGGTTCGGACGCGG
CATCTCTAACGACTTCTGCAACTAAACAAGGTGATAACTACATACTCAACGGCGGCAAAACCTTTATTTCTGGCGCAGGC
GATACCGACGTTTTAGTCGTGATGGCGAGAACCGGCGATGCAGGTGCGAGAGGCGTATCCGCGTTTGTTGTCCCCGCCGA
TGCAGATGGCATTAGCTACGGACGTAAAGAGCCGAAAATGGGCTGGAACAGTCAGCCAACACGCGCGGTAACGTTCGACA
ATGTTTCTATTCCTGCGTCACATTTGCTCGGGGAAGAAGGGCAAGGGTTTGTGTTCGCCATGAAAGGTTTGGATGGCGGA
CGCATCAACATTGCGACCTGCTCTGTCGGTACGGCTCAGCAAGCGTTGAATCAAGCGGCGCAGTACATGCAAGAACGTAA
ACAGTTCGGCAAATCATTAGCTCAATTCCAAGCATTGCAGTTCAAACTGGCAGACATGGCAACCGAGCTTGTCGCTGCTC
GCCAACTGGTGCGGTACGCCGCTAGCAAGTTAGACCGAGGTGACCCAGACGCCACGACTTATTGTGCCATGGCAAAACGC
TTTGCTACCGATGTCGGCTTTCAAGTCTGTGATCAAGCGCTGCAACTTTACGGTGGCTATGGTTACATCAAAGAATACCC
AATGGAACGCTATTTCCGTGATGTTCGAGTGCACCAAATCTTGGAAGGCACCAATGAGATCATGCGTTTGATCATCGCAC
GTCGATTGCTCGCAGAGGAGTCGGCATTGTTATAG

Upstream 100 bases:

>100_bases
ACACAGAGACCAAAACCGTGACGGCTCGTTGGTTTGATGACGATATCCCAACCGGTCCAAACTTGACTATTAACTTGCGC
TAACGAAGTAAGGAGATCAT

Downstream 100 bases:

>100_bases
ACGCAACGCCAAGCTCTGCTTTTATTCATAAAACTCAGGTCATTTTCATCAAGAAAGGATTCAGAGATATGTCATTACCA
GAACAACAAGCGATTCAACA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDFELNEDQRMFADTAQQFAAERLAPMAAGWDEKQIFPKDILREAGELGFLSLYTPEEQGGLGLSRLDASIIFEQLSMGC
TSTTAFMTIHNMVTWMVASFASEEVKDAFCPKLITGDFLGSYCLTEPNAGSDAASLTTSATKQGDNYILNGGKTFISGAG
DTDVLVVMARTGDAGARGVSAFVVPADADGISYGRKEPKMGWNSQPTRAVTFDNVSIPASHLLGEEGQGFVFAMKGLDGG
RINIATCSVGTAQQALNQAAQYMQERKQFGKSLAQFQALQFKLADMATELVAARQLVRYAASKLDRGDPDATTYCAMAKR
FATDVGFQVCDQALQLYGGYGYIKEYPMERYFRDVRVHQILEGTNEIMRLIIARRLLAEESALL

Sequences:

>Translated_384_residues
MDFELNEDQRMFADTAQQFAAERLAPMAAGWDEKQIFPKDILREAGELGFLSLYTPEEQGGLGLSRLDASIIFEQLSMGC
TSTTAFMTIHNMVTWMVASFASEEVKDAFCPKLITGDFLGSYCLTEPNAGSDAASLTTSATKQGDNYILNGGKTFISGAG
DTDVLVVMARTGDAGARGVSAFVVPADADGISYGRKEPKMGWNSQPTRAVTFDNVSIPASHLLGEEGQGFVFAMKGLDGG
RINIATCSVGTAQQALNQAAQYMQERKQFGKSLAQFQALQFKLADMATELVAARQLVRYAASKLDRGDPDATTYCAMAKR
FATDVGFQVCDQALQLYGGYGYIKEYPMERYFRDVRVHQILEGTNEIMRLIIARRLLAEESALL
>Mature_384_residues
MDFELNEDQRMFADTAQQFAAERLAPMAAGWDEKQIFPKDILREAGELGFLSLYTPEEQGGLGLSRLDASIIFEQLSMGC
TSTTAFMTIHNMVTWMVASFASEEVKDAFCPKLITGDFLGSYCLTEPNAGSDAASLTTSATKQGDNYILNGGKTFISGAG
DTDVLVVMARTGDAGARGVSAFVVPADADGISYGRKEPKMGWNSQPTRAVTFDNVSIPASHLLGEEGQGFVFAMKGLDGG
RINIATCSVGTAQQALNQAAQYMQERKQFGKSLAQFQALQFKLADMATELVAARQLVRYAASKLDRGDPDATTYCAMAKR
FATDVGFQVCDQALQLYGGYGYIKEYPMERYFRDVRVHQILEGTNEIMRLIIARRLLAEESALL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=56.5333333333333, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=41.2234042553192, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=38.8297872340425, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=38.8297872340425, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=35.5437665782493, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=35.3723404255319, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=33.7801608579088, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=36.4116094986807, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=35.2941176470588, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=33.2460732984293, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=33.2460732984293, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI4503943, Length=382, Percent_Identity=31.151832460733, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=31.1977715877437, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI38505218, Length=360, Percent_Identity=27.2222222222222, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI211971008, Length=366, Percent_Identity=26.5027322404372, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI48976061, Length=366, Percent_Identity=26.5027322404372, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=30.8900523560209, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=30.6282722513089, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082384, Length=267, Percent_Identity=29.9625468164794, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081702, Length=362, Percent_Identity=24.0331491712707, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=52.1164021164021, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=37.434554973822, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=37.3368146214099, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=37.696335078534, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=35.8288770053476, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=33.7801608579088, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=35.4005167958656, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.5714285714286, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17505929, Length=362, Percent_Identity=32.3204419889503, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=35.84229390681, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=30.4812834224599, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.7965367965368, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=29.1777188328912, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=32.3636363636364, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=296, Percent_Identity=33.1081081081081, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562446, Length=332, Percent_Identity=28.6144578313253, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=30.8333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=283, Percent_Identity=26.8551236749117, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=283, Percent_Identity=26.8551236749117, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531913, Length=165, Percent_Identity=29.0909090909091, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=37.6657824933687, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=35.7142857142857, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.031914893617, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=34.4086021505376, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.7258485639687, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=34.0175953079179, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=29.1338582677165, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24652780, Length=325, Percent_Identity=22.1538461538462, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41877; Mature: 41877

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELNEDQRMFADTAQQFAAERLAPMAAGWDEKQIFPKDILREAGELGFLSLYTPEEQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
GLGLSRLDASIIFEQLSMGCTSTTAFMTIHNMVTWMVASFASEEVKDAFCPKLITGDFLG
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SYCLTEPNAGSDAASLTTSATKQGDNYILNGGKTFISGAGDTDVLVVMARTGDAGARGVS
CHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEECCCCCCEEEEEEEECCCCCCCCCE
AFVVPADADGISYGRKEPKMGWNSQPTRAVTFDNVSIPASHLLGEEGQGFVFAMKGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQQALNQAAQYMQERKQFGKSLAQFQALQFKLADMATELVAARQLVRYA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASKLDRGDPDATTYCAMAKRFATDVGFQVCDQALQLYGGYGYIKEYPMERYFRDVRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
LEGTNEIMRLIIARRLLAEESALL
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFELNEDQRMFADTAQQFAAERLAPMAAGWDEKQIFPKDILREAGELGFLSLYTPEEQG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCC
GLGLSRLDASIIFEQLSMGCTSTTAFMTIHNMVTWMVASFASEEVKDAFCPKLITGDFLG
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
SYCLTEPNAGSDAASLTTSATKQGDNYILNGGKTFISGAGDTDVLVVMARTGDAGARGVS
CHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEECCCCCCEEEEEEEECCCCCCCCCE
AFVVPADADGISYGRKEPKMGWNSQPTRAVTFDNVSIPASHLLGEEGQGFVFAMKGLDGG
EEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSVGTAQQALNQAAQYMQERKQFGKSLAQFQALQFKLADMATELVAARQLVRYA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASKLDRGDPDATTYCAMAKRFATDVGFQVCDQALQLYGGYGYIKEYPMERYFRDVRVHQI
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
LEGTNEIMRLIIARRLLAEESALL
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]