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The map label for this gene is hlyB [H]

Identifier: 156976613

GI number: 156976613

Start: 612776

End: 614545

Strand: Reverse

Name: hlyB [H]

Synonym: VIBHAR_05387

Alternate gene names: 156976613

Gene position: 614545-612776 (Counterclockwise)

Preceding gene: 156976614

Following gene: 156976611

Centisome position: 27.88

GC content: 46.89

Gene sequence:

>1770_bases
ATGTCTATAAGGAACAAGCTCTACTCCCTTGGAGTAATTGCCATTTTAGGTATTGTGGCCCTATTGGGTACCTCGTCACA
CTTCGCGAACCAAAGCCAAGAGCTCAATCACGCGATTAAATTGGTTGGCGATCTCGAAATTCGTCTCCTTAACCTACGTC
GCAATGAAAAAGACTTCTTGTTACGCAGCAATATCAAATACCTCGACAAATTCAATGGAAACGTCGATAAGTTTGTCGGG
ACCGAGCAAGAATTGTCTGGCATCCTAAACCGTTATGACCTCCCTTCTAGCCTCCAATTTACACAGGACTTACTTGCCTA
TCAAAAAGGTTTCCAGAATTTGGTTTCCGCTTACGAGCGCTATGGTTTAAACGCCGACAGCGGTCTACTGGCAAGCTTTG
AAAAAGCGTTGTTGGAAGCTGAACAGAATGCAAACCACCAGCAACTGATGGCGTTAACCAAGTTCGCACAAGGCGTCAAA
GCCGGGAAAATGGACGAAGGTCTGTTGCAAAGTTTGTATGTTCCTTCATTAATCGAGAATGCACGCAAACTTGCTACGCA
AAAGCAGACAATTGGTGTGGCATACAACAAAGGTTTACTGGGTGACACTCGTGCCCTATCACATGCAGTTGAAGAGCAAT
TTAAGACCTTCTCATCTGCGTTAACCCAAGCGGCAGAAGCTCGTGATGCGCAAAACACCATGGTGAAACAAGTCATCACT
GCCGTCGTCTTCGTTGTAATCTTCGCCTTGATTCTACAAATCTCACGCTCAATCAATACCCGTGTTAGCAGCCTACTTGC
GACTATCAAAAATATCAGTGAAAGCAACAATATGGGCTTGCGTTCAGAGTTAGCAGGCAAAGATGAACTGGCGGACATCA
GCCATCACTTAAACGATCTGTTGGATAAGCTTGAGCACCTGATTCACGGCACGCAAGAGAAGTCAACACAGCTATCGGCA
AGCACCGATAATATGCATCGTGAACTCGAAGGCGTGATGGAGCAATTCCACGCTCAAGCCGATCATACTTCATCAATGGC
AACCGCAGTTCAGCAAATGGTCGCCACTATTGGTGAAATCTCGGAAAGTACCTCTGTAGCAGTAGAAGGCGTTCAGCAAG
CCGCAAACAATGCGGAACAAGGTCGTACCGTTGTTGAAACCACAGTAACGAATGTCGGTCAATTAACCGGTATTCTTTCG
AATAGTCAGCAGTCAATCGGATCGCTTAGCGAGCACGTTGCAAAGATTGGCGGTGCAGTGAATATCATTCAAGATATTGC
AGAGCAAACTAACCTACTCGCGCTAAACGCGGCCATTGAAGCAGCGCGGGCGGGCGAGCAAGGTCGTGGCTTCGCCGTGG
TAGCGGATGAAGTACGCGCACTAGCCAGTCGTACTCATCAATCGACAGAAGAAATCACTCGCGTGGTATCAGACATTCAA
TCGCAAATGTCTATGGTGGTATCAGATATCGATCAATGTAACGACCAAGGTCAGCAAACCCTTCAAGCATCTGAGAAGCT
CGACTCAAGCCTTCAGCAGATCATTGCAGACATGCATGCAATTCAAGGTAACTCTGAACGCATCGCTTCTGCCATCGAAG
AGCAAGGCATCGTGATGAATCAAGTCAGCGACTCGATTACTGAGCTGAACGTGATTTCTGAAAACAACATGCAATCCGCA
CAAGAATGTCTGCATGAAGTCGATTCTGTCTCTGCTCAAGCCCATGACATGGACGATGCAGTCGCTGAATTTAAAACCCG
TAGCGCGTAA

Upstream 100 bases:

>100_bases
AACAGCAACGCCAGAAAGTGCTGTACTAGCAAACGTCAGAGCTAGCCATTGGGAGCCTTGTTGGGTTCCTTACTTTAGTC
AACTATTCAGGACAAATTCT

Downstream 100 bases:

>100_bases
GCCAAGTTCGCATATTCAGATTTAAATTAATACCATCAAAAAGCCCGAGCATTCTCATGCTTCGGGCTTTTCTATTTAAG
GTAGCTCAGCGCTTATTCGT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MSIRNKLYSLGVIAILGIVALLGTSSHFANQSQELNHAIKLVGDLEIRLLNLRRNEKDFLLRSNIKYLDKFNGNVDKFVG
TEQELSGILNRYDLPSSLQFTQDLLAYQKGFQNLVSAYERYGLNADSGLLASFEKALLEAEQNANHQQLMALTKFAQGVK
AGKMDEGLLQSLYVPSLIENARKLATQKQTIGVAYNKGLLGDTRALSHAVEEQFKTFSSALTQAAEARDAQNTMVKQVIT
AVVFVVIFALILQISRSINTRVSSLLATIKNISESNNMGLRSELAGKDELADISHHLNDLLDKLEHLIHGTQEKSTQLSA
STDNMHRELEGVMEQFHAQADHTSSMATAVQQMVATIGEISESTSVAVEGVQQAANNAEQGRTVVETTVTNVGQLTGILS
NSQQSIGSLSEHVAKIGGAVNIIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALASRTHQSTEEITRVVSDIQ
SQMSMVVSDIDQCNDQGQQTLQASEKLDSSLQQIIADMHAIQGNSERIASAIEEQGIVMNQVSDSITELNVISENNMQSA
QECLHEVDSVSAQAHDMDDAVAEFKTRSA

Sequences:

>Translated_589_residues
MSIRNKLYSLGVIAILGIVALLGTSSHFANQSQELNHAIKLVGDLEIRLLNLRRNEKDFLLRSNIKYLDKFNGNVDKFVG
TEQELSGILNRYDLPSSLQFTQDLLAYQKGFQNLVSAYERYGLNADSGLLASFEKALLEAEQNANHQQLMALTKFAQGVK
AGKMDEGLLQSLYVPSLIENARKLATQKQTIGVAYNKGLLGDTRALSHAVEEQFKTFSSALTQAAEARDAQNTMVKQVIT
AVVFVVIFALILQISRSINTRVSSLLATIKNISESNNMGLRSELAGKDELADISHHLNDLLDKLEHLIHGTQEKSTQLSA
STDNMHRELEGVMEQFHAQADHTSSMATAVQQMVATIGEISESTSVAVEGVQQAANNAEQGRTVVETTVTNVGQLTGILS
NSQQSIGSLSEHVAKIGGAVNIIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALASRTHQSTEEITRVVSDIQ
SQMSMVVSDIDQCNDQGQQTLQASEKLDSSLQQIIADMHAIQGNSERIASAIEEQGIVMNQVSDSITELNVISENNMQSA
QECLHEVDSVSAQAHDMDDAVAEFKTRSA
>Mature_588_residues
SIRNKLYSLGVIAILGIVALLGTSSHFANQSQELNHAIKLVGDLEIRLLNLRRNEKDFLLRSNIKYLDKFNGNVDKFVGT
EQELSGILNRYDLPSSLQFTQDLLAYQKGFQNLVSAYERYGLNADSGLLASFEKALLEAEQNANHQQLMALTKFAQGVKA
GKMDEGLLQSLYVPSLIENARKLATQKQTIGVAYNKGLLGDTRALSHAVEEQFKTFSSALTQAAEARDAQNTMVKQVITA
VVFVVIFALILQISRSINTRVSSLLATIKNISESNNMGLRSELAGKDELADISHHLNDLLDKLEHLIHGTQEKSTQLSAS
TDNMHRELEGVMEQFHAQADHTSSMATAVQQMVATIGEISESTSVAVEGVQQAANNAEQGRTVVETTVTNVGQLTGILSN
SQQSIGSLSEHVAKIGGAVNIIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALASRTHQSTEEITRVVSDIQS
QMSMVVSDIDQCNDQGQQTLQASEKLDSSLQQIIADMHAIQGNSERIASAIEEQGIVMNQVSDSITELNVISENNMQSAQ
ECLHEVDSVSAQAHDMDDAVAEFKTRSA

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=348, Percent_Identity=27.5862068965517, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788195, Length=310, Percent_Identity=29.6774193548387, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788194, Length=401, Percent_Identity=27.1820448877805, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI2367378, Length=347, Percent_Identity=27.6657060518732, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789453, Length=370, Percent_Identity=26.7567567567568, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 64004; Mature: 63873

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRNKLYSLGVIAILGIVALLGTSSHFANQSQELNHAIKLVGDLEIRLLNLRRNEKDFL
CCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
LRSNIKYLDKFNGNVDKFVGTEQELSGILNRYDLPSSLQFTQDLLAYQKGFQNLVSAYER
HHHCHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YGLNADSGLLASFEKALLEAEQNANHQQLMALTKFAQGVKAGKMDEGLLQSLYVPSLIEN
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ARKLATQKQTIGVAYNKGLLGDTRALSHAVEEQFKTFSSALTQAAEARDAQNTMVKQVIT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVFVVIFALILQISRSINTRVSSLLATIKNISESNNMGLRSELAGKDELADISHHLNDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHH
LDKLEHLIHGTQEKSTQLSASTDNMHRELEGVMEQFHAQADHTSSMATAVQQMVATIGEI
HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SESTSVAVEGVQQAANNAEQGRTVVETTVTNVGQLTGILSNSQQSIGSLSEHVAKIGGAV
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NIIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALASRTHQSTEEITRVVSDIQ
HHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SQMSMVVSDIDQCNDQGQQTLQASEKLDSSLQQIIADMHAIQGNSERIASAIEEQGIVMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
QVSDSITELNVISENNMQSAQECLHEVDSVSAQAHDMDDAVAEFKTRSA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SIRNKLYSLGVIAILGIVALLGTSSHFANQSQELNHAIKLVGDLEIRLLNLRRNEKDFL
CHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHH
LRSNIKYLDKFNGNVDKFVGTEQELSGILNRYDLPSSLQFTQDLLAYQKGFQNLVSAYER
HHHCHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YGLNADSGLLASFEKALLEAEQNANHQQLMALTKFAQGVKAGKMDEGLLQSLYVPSLIEN
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ARKLATQKQTIGVAYNKGLLGDTRALSHAVEEQFKTFSSALTQAAEARDAQNTMVKQVIT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVFVVIFALILQISRSINTRVSSLLATIKNISESNNMGLRSELAGKDELADISHHLNDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHH
LDKLEHLIHGTQEKSTQLSASTDNMHRELEGVMEQFHAQADHTSSMATAVQQMVATIGEI
HHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SESTSVAVEGVQQAANNAEQGRTVVETTVTNVGQLTGILSNSQQSIGSLSEHVAKIGGAV
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NIIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALASRTHQSTEEITRVVSDIQ
HHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SQMSMVVSDIDQCNDQGQQTLQASEKLDSSLQQIIADMHAIQGNSERIASAIEEQGIVMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHH
QVSDSITELNVISENNMQSAQECLHEVDSVSAQAHDMDDAVAEFKTRSA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]