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The map label for this gene is qor [C]

Identifier: 156976481

GI number: 156976481

Start: 502949

End: 503938

Strand: Reverse

Name: qor [C]

Synonym: VIBHAR_05254

Alternate gene names: 156976481

Gene position: 503938-502949 (Counterclockwise)

Preceding gene: 156976482

Following gene: 156976479

Centisome position: 22.86

GC content: 49.9

Gene sequence:

>990_bases
ATGAAAGCGATCACTTACCAAAAAGATCAAGATACCTTCACCTATACCGACATCGACACTCCAGCGCTTGCGAGTGGGTT
AGATGTGTTAGTAAAAGTTCATGCCGTTGGGCTCAACCCTGTCGATGCGAAAGTGAATCTTTGGCACGAGATGGTCGATG
GCATGGACGATACTTTCGTTGGTGGCCTCGATGTTTCGGGGGAAATCGTTGCCATCGGTGACAAGGTATCGGGTTGGCAG
GTAGGTGATCGCGTTCTCTATCATGGCAACATGCGTCGAATGAGCGGTGGTTTCGCCGAATACGCAATTCAAGACTCACG
TACGTTGATTGCCCACCCTGATGTCGCTCCTGAAGTCGCAGCCGCTTCACCTTGCGCGGGCTGGACGGCCTATCGAGCGC
TTGTTGATAAACTGAACATTTCTACGCGTAAGAGCATTTTTATTGCTGGTGGTTCTGGTGGCGTGGGTAGTTTTGCCATT
CAACTCGCTCGCTTCTTCGGTGTAGAAACCATCATCACTACAAGCTCTGGGGCAAACCACGAGTTTGTGCGTTCGTTGGG
TGCAACACACGTCATTGACTACAAACAAGAGGATGTACGTGAGCAGATCATGGCTATCACTGAAGGCTTTGGCGTAGAGG
TATCATTGGACTGCGTTGGCGGCGACAACGACATTCTGTGTGCTTCTGTGCTTGGTTTTGAAGGTGAAATGGTAGAGCTA
GTAAGAACAACGCGTGCAACCGAATACCCAGGAGCCTTTTTGCAAGGGCTCACCTTCCACCAACTGAGCTTAGGCTCTGG
TCATGTTCACGGTGAAAAAGGTTTTGCTTCTATCGTTAACGCTGGGGTGGAATTCTCCCACATGCTAGAACGTGGTGAAG
TCATGGTGCCTAAATTGGAAGTCGTCGCATTAAAAGACGTCGCTCAAGCTCTAGTGTCTATTCGTCAGCAACGAACGGTC
GGAAAGATCGTCGCTAAACTCGTCGACTAA

Upstream 100 bases:

>100_bases
CTTACTCAGCAGGCGCATACCAATAAATCATCAACGCTATCCAACGGTGATTACGCCGTTGGATTTTTATTTTTCGGGCA
AGTGCCCTTTGGGGAAAAGA

Downstream 100 bases:

>100_bases
ATCCCAAGCGACAAAATAAGGGAAAAAGAAGCGCAAACTCCAAAGCTGTTTGCGCTTCTAAGGGGTATTACTTTTCTACA
AGCAGCATTGCTGATTTCGC

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKAITYQKDQDTFTYTDIDTPALASGLDVLVKVHAVGLNPVDAKVNLWHEMVDGMDDTFVGGLDVSGEIVAIGDKVSGWQ
VGDRVLYHGNMRRMSGGFAEYAIQDSRTLIAHPDVAPEVAAASPCAGWTAYRALVDKLNISTRKSIFIAGGSGGVGSFAI
QLARFFGVETIITTSSGANHEFVRSLGATHVIDYKQEDVREQIMAITEGFGVEVSLDCVGGDNDILCASVLGFEGEMVEL
VRTTRATEYPGAFLQGLTFHQLSLGSGHVHGEKGFASIVNAGVEFSHMLERGEVMVPKLEVVALKDVAQALVSIRQQRTV
GKIVAKLVD

Sequences:

>Translated_329_residues
MKAITYQKDQDTFTYTDIDTPALASGLDVLVKVHAVGLNPVDAKVNLWHEMVDGMDDTFVGGLDVSGEIVAIGDKVSGWQ
VGDRVLYHGNMRRMSGGFAEYAIQDSRTLIAHPDVAPEVAAASPCAGWTAYRALVDKLNISTRKSIFIAGGSGGVGSFAI
QLARFFGVETIITTSSGANHEFVRSLGATHVIDYKQEDVREQIMAITEGFGVEVSLDCVGGDNDILCASVLGFEGEMVEL
VRTTRATEYPGAFLQGLTFHQLSLGSGHVHGEKGFASIVNAGVEFSHMLERGEVMVPKLEVVALKDVAQALVSIRQQRTV
GKIVAKLVD
>Mature_329_residues
MKAITYQKDQDTFTYTDIDTPALASGLDVLVKVHAVGLNPVDAKVNLWHEMVDGMDDTFVGGLDVSGEIVAIGDKVSGWQ
VGDRVLYHGNMRRMSGGFAEYAIQDSRTLIAHPDVAPEVAAASPCAGWTAYRALVDKLNISTRKSIFIAGGSGGVGSFAI
QLARFFGVETIITTSSGANHEFVRSLGATHVIDYKQEDVREQIMAITEGFGVEVSLDCVGGDNDILCASVLGFEGEMVEL
VRTTRATEYPGAFLQGLTFHQLSLGSGHVHGEKGFASIVNAGVEFSHMLERGEVMVPKLEVVALKDVAQALVSIRQQRTV
GKIVAKLVD

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=224, Percent_Identity=29.4642857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13236495, Length=224, Percent_Identity=29.4642857142857, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194239676, Length=213, Percent_Identity=30.0469483568075, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI22538446, Length=338, Percent_Identity=27.2189349112426, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI22538444, Length=338, Percent_Identity=27.2189349112426, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI47519420, Length=244, Percent_Identity=29.9180327868852, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI28557745, Length=224, Percent_Identity=30.8035714285714, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI24308257, Length=198, Percent_Identity=31.3131313131313, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI18379349, Length=313, Percent_Identity=25.8785942492013, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI67078404, Length=336, Percent_Identity=25.8928571428571, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790485, Length=222, Percent_Identity=27.4774774774775, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=187, Percent_Identity=32.0855614973262, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536829, Length=232, Percent_Identity=28.8793103448276, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987554, Length=353, Percent_Identity=24.929178470255, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=328, Percent_Identity=23.780487804878, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=236, Percent_Identity=25.4237288135593, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=236, Percent_Identity=26.271186440678, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35261; Mature: 35261

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAITYQKDQDTFTYTDIDTPALASGLDVLVKVHAVGLNPVDAKVNLWHEMVDGMDDTFV
CCCCCCCCCCCCEEEECCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCCCCCEE
GGLDVSGEIVAIGDKVSGWQVGDRVLYHGNMRRMSGGFAEYAIQDSRTLIAHPDVAPEVA
CCCCCCCCEEEECCCCCCCCCCCEEEEECCHHHHCCCHHHEEECCCCEEEECCCCCCHHH
AASPCAGWTAYRALVDKLNISTRKSIFIAGGSGGVGSFAIQLARFFGVETIITTSSGANH
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCCH
EFVRSLGATHVIDYKQEDVREQIMAITEGFGVEVSLDCVGGDNDILCASVLGFEGEMVEL
HHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCCHHHHH
VRTTRATEYPGAFLQGLTFHQLSLGSGHVHGEKGFASIVNAGVEFSHMLERGEVMVPKLE
HHHHCCCCCCCHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHCCCEECCCHH
VVALKDVAQALVSIRQQRTVGKIVAKLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAITYQKDQDTFTYTDIDTPALASGLDVLVKVHAVGLNPVDAKVNLWHEMVDGMDDTFV
CCCCCCCCCCCCEEEECCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCCCCCEE
GGLDVSGEIVAIGDKVSGWQVGDRVLYHGNMRRMSGGFAEYAIQDSRTLIAHPDVAPEVA
CCCCCCCCEEEECCCCCCCCCCCEEEEECCHHHHCCCHHHEEECCCCEEEECCCCCCHHH
AASPCAGWTAYRALVDKLNISTRKSIFIAGGSGGVGSFAIQLARFFGVETIITTSSGANH
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCCH
EFVRSLGATHVIDYKQEDVREQIMAITEGFGVEVSLDCVGGDNDILCASVLGFEGEMVEL
HHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCCHHHHH
VRTTRATEYPGAFLQGLTFHQLSLGSGHVHGEKGFASIVNAGVEFSHMLERGEVMVPKLE
HHHHCCCCCCCHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHCCCEECCCHH
VVALKDVAQALVSIRQQRTVGKIVAKLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA