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The map label for this gene is frwC [H]

Identifier: 156976415

GI number: 156976415

Start: 444538

End: 446409

Strand: Direct

Name: frwC [H]

Synonym: VIBHAR_05188

Alternate gene names: 156976415

Gene position: 444538-446409 (Clockwise)

Preceding gene: 156976412

Following gene: 156976416

Centisome position: 20.17

GC content: 50.64

Gene sequence:

>1872_bases
ATGGACATATTAAACTTTATTGAGCTGGAAAACATTTGCTTGGATTTGCAGGCTCAAACCAAAGATGAAGCGCTCAAAGA
GCTCGTCGAATTGTTGGACGCGGCGGGTAAGCTCACTAGCAAAAGTCAGTTCTTGGCGGACATTTGGAAACGAGAAGAGA
TTGGCAATACCGGCTTTGACGAGGGTATTGCCATTCCTCACGCCAAAAGTAACGCGGTTGCCAAACCCGCAGTCGCAGTG
GGCATCAGCCGAAAAGGGATTGATTATGGTGCCGATGACGGCGAACTGTCTGACGTATTTTTCATGCTGGCTTCTCCGGA
TGGGGACGACCATCACCACATTGAAGTCTTGGCACAAATTTCTACCAAAATCATTGAAGATGGTTTCGTCAATAAGTTAA
AAGCGGCGGAGTCGGTGGAGGAAGCGCGCGAGCTACTTACTGATATTCAATCGAACACGAATGACTCTGGTATCGATCCT
TTAGAATTTGCGTCTGAGCCACCCAGCCCTTGGGCGCAAAAGCTCGGCAGAATGAAAGAACACTTGCTGTTTGGTACCTC
TCATATGATTCCGTTTATTGTCGTGGGCGGCGTGTTGTTGTCTCTGTCTGTGATGATTTCAGGCCATGGTGGCGTTCCGG
AAGAGGGGATACTGGCAGATATCGCTGAGATGGGTATCGCTGGTTTGACGCTGTTTACCGCGGTATTGGGTGGTTATATT
GCCTATTCGATGGCGGATAAGCCGGGTTTGGCTCCGGGTATGATTGGCTCATGGATTGCGGTTAGTCACTACAATACTGG
CTTCTTGGGCGCGATTGTGGTCGGATTTTTCGCCGGCTTTGTGGTTTGGCTGCTGAAGAAGATTCAACTGCCGGACAGCA
TGAGCTCCCTTAGCTCGATCTTTATCTACCCACTGGTTGGTACGTTTGTTACCTGTGGCGCAGTGATGTGGGTGATTGGC
TCACCTATCGCCAGCGCAATGACGACCATGAACGATGTGCTCACAGGTATGGCGGGCTCAGGCAAAGTGATGTTGGGCAC
CGTACTAGGCGCAATGACTGCGTTTGACATGGGCGGCCCTATCAACAAAGTGGCGACTTTGTTTGCTCAAACACAGGTAA
ATACTCAGCCGTGGCTAATGGGTGGTGTCGGTATTGCGATCTGTACTCCGCCTTTGGGTATGGCATTAGCGACTTTCCTA
TCGCCAAGTAAGTTTAAACGTGATGAGCGTGAGGCGGGTAAAGCGGCGGGCATCATGGGCATGATAGGCATCAGTGAAGG
GGCGATTCCGTTTGCTGCCGCTGACCCAGCTCGCGTACTGCCTGCGATTGTTGCTGGTGGCATAGTTGGTAACGTGATTG
GTTTTATGTTCCATGTCATTAACCATGCGCCGTGGGGCGGCTGGATTGTACTGCCTGTTGTGGATGGCAAGATTGGCTAC
ATTGTCGGCACAATCGCAGGCTCGTTTACCACAGCATTGATTGTTATTGCGCTTAAGAAGACCGTCACAGAAGACGACAG
TCCGGTTGGGCAATCTCAAGCTTATACGTCTGTGCAAGGCGAGGGCGAAGCAGACATTCTTGCCGTGACGTCTTGCCCAT
CTGGTGTCGCGCACACCTTCTTAGCGGCGAAGTCATTAGAGAAAGCTGCCTGTGCGTTAGGCATTAAGATCAAGGTCGAA
ACGCAAGGAGCGAACGGCATCATTAACCGAATCACTGACAAAGATATCGCCAAGGCTAGGTTTGTTGTCTTTGCTCACGA
TGTAGCCATCAAAGAGCCGGAGCGCTTCAGAAAAATGAAGGTGCTGGATGTCAGCACTAAAGACGCGATGCTCAATGCTG
CAGCACTGTTGCAGGCGAAAAGAATCCCTTAA

Upstream 100 bases:

>100_bases
TCCTGTATTGGAAAGGACTAGTGTTGGTTACTCTGTACACAGTCATAGATGGAACAGATAACTCATGACTCTCGAGCGTT
AACATTGCAAGGTACAAACA

Downstream 100 bases:

>100_bases
GTATGTAGCTCCCTAACTAAGGCTATCTGCTCGTTAGCTCCATCATTTTTGATGGAGCTTTTTTTATCCCTGCGAAAAGT
GCCGCTATGTTTTTTGGTTG

Product: PTS system fructose-specific IIABC component

Products: protein histidine; sugar phosphate

Alternate protein names: PTS system fructose-like EIIC component 2 [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MDILNFIELENICLDLQAQTKDEALKELVELLDAAGKLTSKSQFLADIWKREEIGNTGFDEGIAIPHAKSNAVAKPAVAV
GISRKGIDYGADDGELSDVFFMLASPDGDDHHHIEVLAQISTKIIEDGFVNKLKAAESVEEARELLTDIQSNTNDSGIDP
LEFASEPPSPWAQKLGRMKEHLLFGTSHMIPFIVVGGVLLSLSVMISGHGGVPEEGILADIAEMGIAGLTLFTAVLGGYI
AYSMADKPGLAPGMIGSWIAVSHYNTGFLGAIVVGFFAGFVVWLLKKIQLPDSMSSLSSIFIYPLVGTFVTCGAVMWVIG
SPIASAMTTMNDVLTGMAGSGKVMLGTVLGAMTAFDMGGPINKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATFL
SPSKFKRDEREAGKAAGIMGMIGISEGAIPFAAADPARVLPAIVAGGIVGNVIGFMFHVINHAPWGGWIVLPVVDGKIGY
IVGTIAGSFTTALIVIALKKTVTEDDSPVGQSQAYTSVQGEGEADILAVTSCPSGVAHTFLAAKSLEKAACALGIKIKVE
TQGANGIINRITDKDIAKARFVVFAHDVAIKEPERFRKMKVLDVSTKDAMLNAAALLQAKRIP

Sequences:

>Translated_623_residues
MDILNFIELENICLDLQAQTKDEALKELVELLDAAGKLTSKSQFLADIWKREEIGNTGFDEGIAIPHAKSNAVAKPAVAV
GISRKGIDYGADDGELSDVFFMLASPDGDDHHHIEVLAQISTKIIEDGFVNKLKAAESVEEARELLTDIQSNTNDSGIDP
LEFASEPPSPWAQKLGRMKEHLLFGTSHMIPFIVVGGVLLSLSVMISGHGGVPEEGILADIAEMGIAGLTLFTAVLGGYI
AYSMADKPGLAPGMIGSWIAVSHYNTGFLGAIVVGFFAGFVVWLLKKIQLPDSMSSLSSIFIYPLVGTFVTCGAVMWVIG
SPIASAMTTMNDVLTGMAGSGKVMLGTVLGAMTAFDMGGPINKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATFL
SPSKFKRDEREAGKAAGIMGMIGISEGAIPFAAADPARVLPAIVAGGIVGNVIGFMFHVINHAPWGGWIVLPVVDGKIGY
IVGTIAGSFTTALIVIALKKTVTEDDSPVGQSQAYTSVQGEGEADILAVTSCPSGVAHTFLAAKSLEKAACALGIKIKVE
TQGANGIINRITDKDIAKARFVVFAHDVAIKEPERFRKMKVLDVSTKDAMLNAAALLQAKRIP
>Mature_623_residues
MDILNFIELENICLDLQAQTKDEALKELVELLDAAGKLTSKSQFLADIWKREEIGNTGFDEGIAIPHAKSNAVAKPAVAV
GISRKGIDYGADDGELSDVFFMLASPDGDDHHHIEVLAQISTKIIEDGFVNKLKAAESVEEARELLTDIQSNTNDSGIDP
LEFASEPPSPWAQKLGRMKEHLLFGTSHMIPFIVVGGVLLSLSVMISGHGGVPEEGILADIAEMGIAGLTLFTAVLGGYI
AYSMADKPGLAPGMIGSWIAVSHYNTGFLGAIVVGFFAGFVVWLLKKIQLPDSMSSLSSIFIYPLVGTFVTCGAVMWVIG
SPIASAMTTMNDVLTGMAGSGKVMLGTVLGAMTAFDMGGPINKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATFL
SPSKFKRDEREAGKAAGIMGMIGISEGAIPFAAADPARVLPAIVAGGIVGNVIGFMFHVINHAPWGGWIVLPVVDGKIGY
IVGTIAGSFTTALIVIALKKTVTEDDSPVGQSQAYTSVQGEGEADILAVTSCPSGVAHTFLAAKSLEKAACALGIKIKVE
TQGANGIINRITDKDIAKARFVVFAHDVAIKEPERFRKMKVLDVSTKDAMLNAAALLQAKRIP

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane [H]

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790386, Length=313, Percent_Identity=45.6869009584665, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788492, Length=330, Percent_Identity=41.5151515151515, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1786951, Length=346, Percent_Identity=30.9248554913295, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI87082348, Length=372, Percent_Identity=30.1075268817204, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788729, Length=370, Percent_Identity=28.6486486486486, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1788730, Length=93, Percent_Identity=43.010752688172, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790387, Length=92, Percent_Identity=47.8260869565217, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI2367327, Length=128, Percent_Identity=30.46875, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788726, Length=145, Percent_Identity=28.9655172413793, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790390, Length=82, Percent_Identity=40.2439024390244, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1789597, Length=143, Percent_Identity=30.0699300699301, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI48994992, Length=137, Percent_Identity=27.007299270073, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013014
- InterPro:   IPR006327 [H]

Pfam domain/function: NA

EC number: 2.7.1.69

Molecular weight: Translated: 65582; Mature: 65582

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILNFIELENICLDLQAQTKDEALKELVELLDAAGKLTSKSQFLADIWKREEIGNTGFD
CCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
EGIAIPHAKSNAVAKPAVAVGISRKGIDYGADDGELSDVFFMLASPDGDDHHHIEVLAQI
CCEECCCCCCCCCCCCHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
STKIIEDGFVNKLKAAESVEEARELLTDIQSNTNDSGIDPLEFASEPPSPWAQKLGRMKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHH
HLLFGTSHMIPFIVVGGVLLSLSVMISGHGGVPEEGILADIAEMGIAGLTLFTAVLGGYI
HHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYSMADKPGLAPGMIGSWIAVSHYNTGFLGAIVVGFFAGFVVWLLKKIQLPDSMSSLSSI
HHHCCCCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FIYPLVGTFVTCGAVMWVIGSPIASAMTTMNDVLTGMAGSGKVMLGTVLGAMTAFDMGGP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
INKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATFLSPSKFKRDEREAGKAAGIMG
HHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHHHHHCCCHHHCCHHHHHHHHHCEEE
MIGISEGAIPFAAADPARVLPAIVAGGIVGNVIGFMFHVINHAPWGGWIVLPVVDGKIGY
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHH
IVGTIAGSFTTALIVIALKKTVTEDDSPVGQSQAYTSVQGEGEADILAVTSCPSGVAHTF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCHHHHHH
LAAKSLEKAACALGIKIKVETQGANGIINRITDKDIAKARFVVFAHDVAIKEPERFRKMK
HHHHHHHHHHHHEEEEEEEEECCCCCHHHHCCCHHHHHHEEEEEEECHHHCCHHHHHHEE
VLDVSTKDAMLNAAALLQAKRIP
EEECCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDILNFIELENICLDLQAQTKDEALKELVELLDAAGKLTSKSQFLADIWKREEIGNTGFD
CCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
EGIAIPHAKSNAVAKPAVAVGISRKGIDYGADDGELSDVFFMLASPDGDDHHHIEVLAQI
CCEECCCCCCCCCCCCHHEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
STKIIEDGFVNKLKAAESVEEARELLTDIQSNTNDSGIDPLEFASEPPSPWAQKLGRMKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHH
HLLFGTSHMIPFIVVGGVLLSLSVMISGHGGVPEEGILADIAEMGIAGLTLFTAVLGGYI
HHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYSMADKPGLAPGMIGSWIAVSHYNTGFLGAIVVGFFAGFVVWLLKKIQLPDSMSSLSSI
HHHCCCCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FIYPLVGTFVTCGAVMWVIGSPIASAMTTMNDVLTGMAGSGKVMLGTVLGAMTAFDMGGP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
INKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATFLSPSKFKRDEREAGKAAGIMG
HHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHHHHHCCCHHHCCHHHHHHHHHCEEE
MIGISEGAIPFAAADPARVLPAIVAGGIVGNVIGFMFHVINHAPWGGWIVLPVVDGKIGY
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHH
IVGTIAGSFTTALIVIALKKTVTEDDSPVGQSQAYTSVQGEGEADILAVTSCPSGVAHTF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCHHHHHH
LAAKSLEKAACALGIKIKVETQGANGIINRITDKDIAKARFVVFAHDVAIKEPERFRKMK
HHHHHHHHHHHHEEEEEEEEECCCCCHHHHCCCHHHHHHEEEEEEECHHHCCHHHHHHEE
VLDVSTKDAMLNAAALLQAKRIP
EEECCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 7773398 [H]