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The map label for this gene is gltP [H]

Identifier: 156976096

GI number: 156976096

Start: 133935

End: 135239

Strand: Reverse

Name: gltP [H]

Synonym: VIBHAR_04867

Alternate gene names: 156976096

Gene position: 135239-133935 (Counterclockwise)

Preceding gene: 156976097

Following gene: 156976091

Centisome position: 6.14

GC content: 48.12

Gene sequence:

>1305_bases
ATGAATACCAAGAAACCGATGTCGCTCACCAGCCGCGTAATTTTGGGTATGGTAGCGGGTATCTTGACAGGATTTGCAAT
TCGCACACTTTTCGCCGACAACGGATTTGTCGACGCATACATTGTTAATGGATTATTCGAAGTTGGTGGACAGATCTTCG
TTGCCAGCTTAAAAATGCTTGTAGTACCACTGGTGTTCGTTTCACTAGTTTGTGGTACAAGCTCTCTAAAAGACCTATCA
ACATTAGGTCGCATGGGTGGTAAAACCCTTGCTTTCTACGTAGCAACGACTGCTATCGCAATCACACTTGCTCTAACCAT
GGGTACGCTATTCCAGCCGGGCGCTGGTGCAGACCTAACCGCAGCAAGTTCATTCAAATCAGCAGAAGCGCCATCTTTGG
GTCAAGTGATCATTGATATGTTCCCGACTAACCCAATCAGCGCAATGGCAGAAGGTAAAACTCTGCAAGTGATCGTGTTC
GCCGTACTATTCGGTATCGCAATCAGTGCAGCTGGTAAGCCTGGTGAGCATATCGCCGCTTTCTTCTCTGATCTGAATAA
AGTGATCATGAAATTGGTTGCGATTCTGATGAACCTAGCGCCTTACGGTGTGTTCTTCCTAATGGCGAAGCTGTTTACAG
GTCTTGGTCTAAGCGCAATCTTCAACCTTGCTGAATACTTTGTTGTACTGGCAGGTACGCTATTGCTGCACGGTCTGGTG
ACTTACAGCTTGATGCTAAAAGGCTTCACTGGTCTAAACCCAATTACGTTCCTACGTAAGATGGAAGACGCCATCATGTT
TGCTTTCTCTACAGCATCATCGAACGCGACCATTCCAGTGACAATGGAGACAGCTAAGCACCGCATGGGTGTTGAGAACC
GCGTATCATCGTTCACAGTGCCACTAGGCGCAACCGTGAACATGGACGGCACGGCGATCATGCAAGGTGTGGCGACAGCG
TTCATCGCACAGGCATTCAACATCGACCTAACTATGGGTGACTACCTAATGGTTATCATGACGGCAACATTAGCGTCTAT
CGGTACCGCAGGCGTTCCTGGTGTTGGTCTAGTAATGTTGGCAATGGTATTGAACCAAGTAGGTCTGCCACTAGAGGGCA
TTGCACTTATCATGGGTGTTGACCGTCTACTTGATATGATTCGTACCGCAGTTAACATCACCGGTGACAGCGCAGTGACG
ATCATTGTTGCTAAATCGGAAGGTGCATTGGATGAAGCTCGCTTCAATGATCCAATGGCCGGCGTAGCCGAAGAAGAAGT
GCACCTGAAACGTGCTGACGCCTAA

Upstream 100 bases:

>100_bases
ACCATTTAGACGATTATTCTTTCGTATTTTCACACTCCACTGCTAATCTGCTCGCCGCCTTGAAGTGAACTCAAGGTGCA
TAACTATAAGGAGTGTTCTC

Downstream 100 bases:

>100_bases
ATCGTTCTACGATTAAACTATCCTGTCTAAATGAAAGCCCCGATGGAAACGTCGGGGCTTTTGTTTTATCTGCAATCTAA
AGAATAGGTCATAGCAGCCT

Product: glutamate-aspartate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNTKKPMSLTSRVILGMVAGILTGFAIRTLFADNGFVDAYIVNGLFEVGGQIFVASLKMLVVPLVFVSLVCGTSSLKDLS
TLGRMGGKTLAFYVATTAIAITLALTMGTLFQPGAGADLTAASSFKSAEAPSLGQVIIDMFPTNPISAMAEGKTLQVIVF
AVLFGIAISAAGKPGEHIAAFFSDLNKVIMKLVAILMNLAPYGVFFLMAKLFTGLGLSAIFNLAEYFVVLAGTLLLHGLV
TYSLMLKGFTGLNPITFLRKMEDAIMFAFSTASSNATIPVTMETAKHRMGVENRVSSFTVPLGATVNMDGTAIMQGVATA
FIAQAFNIDLTMGDYLMVIMTATLASIGTAGVPGVGLVMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSAVT
IIVAKSEGALDEARFNDPMAGVAEEEVHLKRADA

Sequences:

>Translated_434_residues
MNTKKPMSLTSRVILGMVAGILTGFAIRTLFADNGFVDAYIVNGLFEVGGQIFVASLKMLVVPLVFVSLVCGTSSLKDLS
TLGRMGGKTLAFYVATTAIAITLALTMGTLFQPGAGADLTAASSFKSAEAPSLGQVIIDMFPTNPISAMAEGKTLQVIVF
AVLFGIAISAAGKPGEHIAAFFSDLNKVIMKLVAILMNLAPYGVFFLMAKLFTGLGLSAIFNLAEYFVVLAGTLLLHGLV
TYSLMLKGFTGLNPITFLRKMEDAIMFAFSTASSNATIPVTMETAKHRMGVENRVSSFTVPLGATVNMDGTAIMQGVATA
FIAQAFNIDLTMGDYLMVIMTATLASIGTAGVPGVGLVMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSAVT
IIVAKSEGALDEARFNDPMAGVAEEEVHLKRADA
>Mature_434_residues
MNTKKPMSLTSRVILGMVAGILTGFAIRTLFADNGFVDAYIVNGLFEVGGQIFVASLKMLVVPLVFVSLVCGTSSLKDLS
TLGRMGGKTLAFYVATTAIAITLALTMGTLFQPGAGADLTAASSFKSAEAPSLGQVIIDMFPTNPISAMAEGKTLQVIVF
AVLFGIAISAAGKPGEHIAAFFSDLNKVIMKLVAILMNLAPYGVFFLMAKLFTGLGLSAIFNLAEYFVVLAGTLLLHGLV
TYSLMLKGFTGLNPITFLRKMEDAIMFAFSTASSNATIPVTMETAKHRMGVENRVSSFTVPLGATVNMDGTAIMQGVATA
FIAQAFNIDLTMGDYLMVIMTATLASIGTAGVPGVGLVMLAMVLNQVGLPLEGIALIMGVDRLLDMIRTAVNITGDSAVT
IIVAKSEGALDEARFNDPMAGVAEEEVHLKRADA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=441, Percent_Identity=32.1995464852608, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI21314632, Length=392, Percent_Identity=33.6734693877551, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI194239697, Length=452, Percent_Identity=31.4159292035398, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI66773030, Length=400, Percent_Identity=32.5, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4827012, Length=322, Percent_Identity=36.9565217391304, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI5032093, Length=372, Percent_Identity=34.6774193548387, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI223468566, Length=256, Percent_Identity=37.890625, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI223468564, Length=245, Percent_Identity=38.3673469387755, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI40254478, Length=260, Percent_Identity=39.2307692307692, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI262359914, Length=382, Percent_Identity=28.7958115183246, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI301601644, Length=166, Percent_Identity=40.3614457831325, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=34.916864608076, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789947, Length=386, Percent_Identity=30.8290155440415, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788024, Length=439, Percent_Identity=30.5239179954442, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789473, Length=272, Percent_Identity=27.9411764705882, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=465, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71983106, Length=411, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71983099, Length=411, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71996953, Length=445, Percent_Identity=31.2359550561798, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17537407, Length=384, Percent_Identity=35.15625, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI193206654, Length=421, Percent_Identity=30.8788598574822, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=427, Percent_Identity=31.1475409836066, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24583025, Length=433, Percent_Identity=32.1016166281755, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17137668, Length=433, Percent_Identity=32.1016166281755, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24583023, Length=433, Percent_Identity=32.1016166281755, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI281360483, Length=464, Percent_Identity=27.5862068965517, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17137666, Length=464, Percent_Identity=27.5862068965517, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281360481, Length=464, Percent_Identity=27.5862068965517, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45499; Mature: 45499

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHCCCC
>Mature Secondary Structure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CCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]