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The map label for this gene is rot [H]

Identifier: 156980081

GI number: 156980081

Start: 1901004

End: 1901465

Strand: Reverse

Name: rot [H]

Synonym: SAHV_1750

Alternate gene names: 156980081

Gene position: 1901465-1901004 (Counterclockwise)

Preceding gene: 156980082

Following gene: 156980078

Centisome position: 66.02

GC content: 31.17

Gene sequence:

>462_bases
ATGTTTGTTAATACTTGTATGGTAGCTAAATATGTGATTATTAATTGGGAGATGTTTAGCATGAAAAAAGTAAATAACGA
CACTGTATTTGGGATTTTGCAATTAGAAACACTTTTGGGTGACATTAACTCAATTTTCAGCGAGATTGAAAGCGAATACA
AAATGTCTAGAGAAGAAATTTTAATTTTACTAACTTTATGGCAAAAAGGTTCTATGACGCTTAAAGAAATGGACAGATTT
GTTGAAGTTAAACCGTATAAGCGTACGAGAACGTATAATAATTTAGTTGAATTAGAATGGATTTACAAAGAGCGTCCTGT
TGACGATGAAAGAACAGTTATTATTCATTTCAATGAAAAGTTACAACAAGAGAAAGTAGAGTTGTTGAATTTCATCAGTG
ATGCCATTGCAAGTAGAGCAACAGCAATGCAAAATAGTTTAAACGCAATTATTGCTGTGTAA

Upstream 100 bases:

>100_bases
TTTAATTTTATTCAACTTTGACAATTGAATAGAAAGCAAGTTTATTTACACTTGTAGTTTTATGCATAAGTTAGCACATA
CAAGTTTTGGGATTGTTGGG

Downstream 100 bases:

>100_bases
GTTTAATAGCATAAAAAGAGGTTTTCATTAAGTTGAAAACCTCTTTTTGTTGTTGTTGGTATTAATTTTTCAAATGTTGA
CTACTCAATCCTAAATTATA

Product: repressor of toxins Rot

Products: NA

Alternate protein names: Repressor of toxins [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRF
VEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV

Sequences:

>Translated_153_residues
MFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRF
VEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
>Mature_153_residues
MFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRF
VEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV

Specific function: Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence. Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and protease

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rot family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010166
- InterPro:   IPR000835
- InterPro:   IPR016998
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 18009; Mature: 18009

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEI
CCCCHHHHHHHHEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
LILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEK
EEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCEEEEEEEECCCCCCCCCEEEEEECHH
LQQEKVELLNFISDAIASRATAMQNSLNAIIAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure
MFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEI
CCCCHHHHHHHHEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
LILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEK
EEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCEEEEEEEECCCCCCCCCEEEEEECHH
LQQEKVELLNFISDAIASRATAMQNSLNAIIAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10809700; 12511508 [H]