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The map label for this gene is hisC [H]

Identifier: 156938120

GI number: 156938120

Start: 1185822

End: 1186889

Strand: Reverse

Name: hisC [H]

Synonym: Igni_1333

Alternate gene names: 156938120

Gene position: 1186889-1185822 (Counterclockwise)

Preceding gene: 156938122

Following gene: 156938118

Centisome position: 91.47

GC content: 55.24

Gene sequence:

>1068_bases
GTGAAATGTCTTAAGAGAGAATGGCTACGGGAGATGAAGACCTACCACTTGCCCCAGAAGCCTAAGAGCATTAGGGCGAG
GTTGCACTTAAACGAGAACCCCAACCCCCCTCCCCGGCGCGTAATAGAGGCAGCCTTGAAGGCCGCGGAGGCCGGCAACT
TGTACCCGGACCCGGAGAGGCTGTGGAAACTAAGGGAGGTCGCCGCTAGGTATTACGGGGTTCCGGGGCCTGAGTGGGTG
CTCCCCACCTTAGGCTCCGACAGCGCCCTCCGCTTAACCTTCGAGTGCTGCGCCCTCAAGGGCTCGGCGAGGCTACCCTA
CCCGAGCTTCCAAGCCTACCCTCCCCTCTTGGGGGCCGCGGGGGCGACCTTGCTGTATTCTAACTTACAGATCGAGGGCG
ATAAGTTCGTCCTTAACTTGGACGACTTCCTATCGACTAAAGCCGACATCGCAGTGATAGACACTCCCAACAACCCTACC
GGCTCCTTGCTGTTGAGTCCCGAACAGCTGGACCGCTTGAGCGGGGCCTTCCCCTCCGTCCTGGTTGACGAGGCTTATGC
CGAGTTCGCCCCCTTCAGCTTGACGCCATTCGTCACTGAGTATGACAACTTATTCGTGACTAGAACTCTAAGCAAGGCAT
TTGCTTTGGCCGGCTTCAGGATAGGTTTCCTAATATCGAGTCCGGAGAACGTTACGGAAGTGTCGAAGATGGTTTTGCCG
TACGACATACCTTCCGTGACCGTTGAGGCGGCCCTAGCGGCGCTCAGCGACCCGTCGTACTCGAGGGACTACATAAATTA
TGTAAACGAAGAGAAGAAGAGGATGAAGGACAAGTTGGAGTCGTTGGGTTGGAAGGTCTTCGAGAGCTATACCAACTTCG
TCTTGGTGAGGGCTTTCAAAGGGGTGGTGGACGAGTTTAGGAAGATGGGTATAATGGTGAGGAAGGTACCTCTCGGAGAG
GATTGGTTTAGGGTAAGCGTTGGGAGCGAGGAGGAGATGAAGCTGTTCTACGAGGCTTCTGAGAGCTTGGCGAAAAAGTT
TGGGAACCAAATTACTCCATCGGCTTAA

Upstream 100 bases:

>100_bases
GAACGTGGTGTCGACCACGCCTATACAAACCAACTACTTCCCCGGAACCATTACAAGGCCCCCTTATTTTACCCCCACCC
CACCTCGGGTGGGAAACACG

Downstream 100 bases:

>100_bases
CGTGGATTAAGCACTTCTCCTGGTTAACCGAGTCGTCCACTTGGACGTGCCACTTCTTCCCCGTGATCTCCTCCAGTATT
CCCTTTATCAAACCAGCCTC

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKCLKREWLREMKTYHLPQKPKSIRARLHLNENPNPPPRRVIEAALKAAEAGNLYPDPERLWKLREVAARYYGVPGPEWV
LPTLGSDSALRLTFECCALKGSARLPYPSFQAYPPLLGAAGATLLYSNLQIEGDKFVLNLDDFLSTKADIAVIDTPNNPT
GSLLLSPEQLDRLSGAFPSVLVDEAYAEFAPFSLTPFVTEYDNLFVTRTLSKAFALAGFRIGFLISSPENVTEVSKMVLP
YDIPSVTVEAALAALSDPSYSRDYINYVNEEKKRMKDKLESLGWKVFESYTNFVLVRAFKGVVDEFRKMGIMVRKVPLGE
DWFRVSVGSEEEMKLFYEASESLAKKFGNQITPSA

Sequences:

>Translated_355_residues
MKCLKREWLREMKTYHLPQKPKSIRARLHLNENPNPPPRRVIEAALKAAEAGNLYPDPERLWKLREVAARYYGVPGPEWV
LPTLGSDSALRLTFECCALKGSARLPYPSFQAYPPLLGAAGATLLYSNLQIEGDKFVLNLDDFLSTKADIAVIDTPNNPT
GSLLLSPEQLDRLSGAFPSVLVDEAYAEFAPFSLTPFVTEYDNLFVTRTLSKAFALAGFRIGFLISSPENVTEVSKMVLP
YDIPSVTVEAALAALSDPSYSRDYINYVNEEKKRMKDKLESLGWKVFESYTNFVLVRAFKGVVDEFRKMGIMVRKVPLGE
DWFRVSVGSEEEMKLFYEASESLAKKFGNQITPSA
>Mature_355_residues
MKCLKREWLREMKTYHLPQKPKSIRARLHLNENPNPPPRRVIEAALKAAEAGNLYPDPERLWKLREVAARYYGVPGPEWV
LPTLGSDSALRLTFECCALKGSARLPYPSFQAYPPLLGAAGATLLYSNLQIEGDKFVLNLDDFLSTKADIAVIDTPNNPT
GSLLLSPEQLDRLSGAFPSVLVDEAYAEFAPFSLTPFVTEYDNLFVTRTLSKAFALAGFRIGFLISSPENVTEVSKMVLP
YDIPSVTVEAALAALSDPSYSRDYINYVNEEKKRMKDKLESLGWKVFESYTNFVLVRAFKGVVDEFRKMGIMVRKVPLGE
DWFRVSVGSEEEMKLFYEASESLAKKFGNQITPSA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=292, Percent_Identity=31.1643835616438, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=363, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39842; Mature: 39842

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCLKREWLREMKTYHLPQKPKSIRARLHLNENPNPPPRRVIEAALKAAEAGNLYPDPER
CCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
LWKLREVAARYYGVPGPEWVLPTLGSDSALRLTFECCALKGSARLPYPSFQAYPPLLGAA
HHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHCC
GATLLYSNLQIEGDKFVLNLDDFLSTKADIAVIDTPNNPTGSLLLSPEQLDRLSGAFPSV
CHHHEEECEEEECCEEEEECHHHHCCCCCEEEEECCCCCCCCEEECHHHHHHHCCCCHHH
LVDEAYAEFAPFSLTPFVTEYDNLFVTRTLSKAFALAGFRIGFLISSPENVTEVSKMVLP
HHHHHHHHHCCCCCCCHHHHHCCEEEHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCC
YDIPSVTVEAALAALSDPSYSRDYINYVNEEKKRMKDKLESLGWKVFESYTNFVLVRAFK
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVDEFRKMGIMVRKVPLGEDWFRVSVGSEEEMKLFYEASESLAKKFGNQITPSA
HHHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKCLKREWLREMKTYHLPQKPKSIRARLHLNENPNPPPRRVIEAALKAAEAGNLYPDPER
CCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
LWKLREVAARYYGVPGPEWVLPTLGSDSALRLTFECCALKGSARLPYPSFQAYPPLLGAA
HHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHCC
GATLLYSNLQIEGDKFVLNLDDFLSTKADIAVIDTPNNPTGSLLLSPEQLDRLSGAFPSV
CHHHEEECEEEECCEEEEECHHHHCCCCCEEEEECCCCCCCCEEECHHHHHHHCCCCHHH
LVDEAYAEFAPFSLTPFVTEYDNLFVTRTLSKAFALAGFRIGFLISSPENVTEVSKMVLP
HHHHHHHHHCCCCCCCHHHHHCCEEEHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCC
YDIPSVTVEAALAALSDPSYSRDYINYVNEEKKRMKDKLESLGWKVFESYTNFVLVRAFK
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVDEFRKMGIMVRKVPLGEDWFRVSVGSEEEMKLFYEASESLAKKFGNQITPSA
HHHHHHHHCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9209067; 10701121; 11427726 [H]