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The map label for this gene is trpC [H]

Identifier: 156938116

GI number: 156938116

Start: 1182111

End: 1182875

Strand: Direct

Name: trpC [H]

Synonym: Igni_1329

Alternate gene names: 156938116

Gene position: 1182111-1182875 (Clockwise)

Preceding gene: 156938115

Following gene: 156938117

Centisome position: 91.1

GC content: 57.65

Gene sequence:

>765_bases
TTGCTAGAGAAGATAATTGATATCACAGTTAAGAGAGTGGAAGAGGAGCGCAAGCGGTTGGCTCTGCCCAAGAGGTTCAA
GCCCGTGAGGGACTTCCGAGGGAGCTTGGAGAGGGGCGCTTTTGCTGTCATAGCGGAGTTCAAGCCCTCCTCCCCCAGCG
GGGTCAAGGCGAGGTGGGGGCTGTTGGAATATTTGGAGAGGGTCAAGGCGGCTGACGCCCTCTCAGTGCTCACCGAGCCC
CGCTTCTTCAAGGGCTCCTACTACAACTTGGCGAGGGCCGCGACGTTAACGGACAAGCCCATATTGTTTAAAGACTTCGT
GGTCGACCCCTTCCAGATCGAGGCCGCCTACGCCTTCGGAGCGGACGCGGTGTTGTTGATGATTGACGTCTTAGGAGAGG
ACGACCTAAAGTACATGGCTCTCAAAGCGAAGTCGCTGGGCCTCCAGACGTTGGTAGAGGTCAGCAAGCCCGAGGACGCG
AGCGTTTCCGAAGAGGCGTGGGTTGATGTGTTGGGCGTGAACTCGAGAGACTTTAAGACGTTAAAAACCGACATAAAGAG
GATATTTAAAGCTACAAGGTACATAGCAGAGAGGGCCTTCCCCCTAGCCGAGTCCGGGGTTAAGGGGTCGAGGGACGCTT
ACGAGTTGGCCCTCAGGGGCTACCGGGGAGCGTTGGTGGGGACGAGCTTGATGGAGAGTCCCGACCCGCTGGGCTCCTTG
CTGTCTATAAAGAGGGCCGGCAGCGCGGGGCTGGGCAGGATTTAG

Upstream 100 bases:

>100_bases
GGGGAAGGCGAAGAAGAGTAGGGCCCAGAAGGCCCCCTTCCACGCGAACTCCTTCCTCCCCTTATCTTCCCCCAAAGCGC
CAGCACCTCTGGGGCCGCGC

Downstream 100 bases:

>100_bases
GGGCCCTCCCGAAGGGCGGGCCCAGAGGTAAACGTTCGTTGCCGTTCGACCCGCTCCCCCCAGACACTGTCATGAAGACG
GTAAACCTAAAGAAGTACTA

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MLEKIIDITVKRVEEERKRLALPKRFKPVRDFRGSLERGAFAVIAEFKPSSPSGVKARWGLLEYLERVKAADALSVLTEP
RFFKGSYYNLARAATLTDKPILFKDFVVDPFQIEAAYAFGADAVLLMIDVLGEDDLKYMALKAKSLGLQTLVEVSKPEDA
SVSEEAWVDVLGVNSRDFKTLKTDIKRIFKATRYIAERAFPLAESGVKGSRDAYELALRGYRGALVGTSLMESPDPLGSL
LSIKRAGSAGLGRI

Sequences:

>Translated_254_residues
MLEKIIDITVKRVEEERKRLALPKRFKPVRDFRGSLERGAFAVIAEFKPSSPSGVKARWGLLEYLERVKAADALSVLTEP
RFFKGSYYNLARAATLTDKPILFKDFVVDPFQIEAAYAFGADAVLLMIDVLGEDDLKYMALKAKSLGLQTLVEVSKPEDA
SVSEEAWVDVLGVNSRDFKTLKTDIKRIFKATRYIAERAFPLAESGVKGSRDAYELALRGYRGALVGTSLMESPDPLGSL
LSIKRAGSAGLGRI
>Mature_254_residues
MLEKIIDITVKRVEEERKRLALPKRFKPVRDFRGSLERGAFAVIAEFKPSSPSGVKARWGLLEYLERVKAADALSVLTEP
RFFKGSYYNLARAATLTDKPILFKDFVVDPFQIEAAYAFGADAVLLMIDVLGEDDLKYMALKAKSLGLQTLVEVSKPEDA
SVSEEAWVDVLGVNSRDFKTLKTDIKRIFKATRYIAERAFPLAESGVKGSRDAYELALRGYRGALVGTSLMESPDPLGSL
LSIKRAGSAGLGRI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=234, Percent_Identity=31.6239316239316, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322638, Length=225, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28112; Mature: 28112

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKIIDITVKRVEEERKRLALPKRFKPVRDFRGSLERGAFAVIAEFKPSSPSGVKARWG
CCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
LLEYLERVKAADALSVLTEPRFFKGSYYNLARAATLTDKPILFKDFVVDPFQIEAAYAFG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEHHHHCCCCCEEEEEHHCC
ADAVLLMIDVLGEDDLKYMALKAKSLGLQTLVEVSKPEDASVSEEAWVDVLGVNSRDFKT
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHEEECCCCCHHHH
LKTDIKRIFKATRYIAERAFPLAESGVKGSRDAYELALRGYRGALVGTSLMESPDPLGSL
HHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHH
LSIKRAGSAGLGRI
HHHHHCCCCCCCCC
>Mature Secondary Structure
MLEKIIDITVKRVEEERKRLALPKRFKPVRDFRGSLERGAFAVIAEFKPSSPSGVKARWG
CCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHH
LLEYLERVKAADALSVLTEPRFFKGSYYNLARAATLTDKPILFKDFVVDPFQIEAAYAFG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEHHHHCCCCCEEEEEHHCC
ADAVLLMIDVLGEDDLKYMALKAKSLGLQTLVEVSKPEDASVSEEAWVDVLGVNSRDFKT
CCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHEEECCCCCHHHH
LKTDIKRIFKATRYIAERAFPLAESGVKGSRDAYELALRGYRGALVGTSLMESPDPLGSL
HHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHH
LSIKRAGSAGLGRI
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]