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The map label for this gene is MCM [H]

Identifier: 156938084

GI number: 156938084

Start: 1151795

End: 1153864

Strand: Reverse

Name: MCM [H]

Synonym: Igni_1297

Alternate gene names: 156938084

Gene position: 1153864-1151795 (Counterclockwise)

Preceding gene: 156938085

Following gene: 156938079

Centisome position: 88.93

GC content: 56.18

Gene sequence:

>2070_bases
GTGAGTGAGGCGGGCTTCCTCGAGGAGAAGTTACCGGTCGAGGAGCGGTTCAGAGAGTTCTTGGAGTCCTACGAAGTAAA
CGGGAGAGTGAAGTACAAGGACGAAATAAGGAACGCCGTGGCCGAGAGGAGGGCGAGCGTAGTAGTCGACTTCACCGACG
TAATAGAGTTTGACCAAGAGTTGGCCGAAGAGATAGTCGAGAACCCGCTGGAAACGTTAGATAAACTGGATCAAGTAGTT
ACAGAAATAGCAAGCGCGTTTGCAAACAAAAAGTACCCGATGAGAGTTCGCTTCACCAACTTGCCGGAGAAGGTGAGGCT
CAGAGACCTTAGAGAGAGGTACGTCGGCAAGTTAGTGGCGTTCGACGGGATAGTTACGAAGGCGACCAACGTAAAGGGCA
AGCCGAAGAAGCTCTACTTCCGGTGCGAGGCGTGCGGGACGGTGTTCCCGGTCGAGCAGAGGGGAAAGTACTACCAAGCC
CCTACCGTCTGTCCCAACCCGGAGTGTCCTAAGAAGACCGGCCCTTTCACCTTGTTAGAGAACCACCCCAAGAACGAGTA
CGTGGACTGGCAGCTCCTAGTGGTGCAAGAGAAGCCGGAGGAGCTCCCGCCGGGACAAATGCCTAGGAGCATAGAAGTTA
TAGTGGAGGGCAAGGACCTCGTCGACGTAGCGCGCCCCGGAGATAGGGTTACAGTAATAGGCGTCTTGGAGGCGGTTCCC
AACAGAGTGCCCAAGAGAGGTTCCATGGTGGTTTTCGACTTCAAGATGATAGCCAACAACATAGAGGTTTCGCAGAAGGT
GTTGGAAGACGTCCACTTGAGTCCGGAGGACGTCGAAAGAATAAAGGAGCTCTCGAAAGACCCCTGGATCCACAAGAGCA
TAATCTTGAGCATAGCCCCGGCTATATACGGCCACTGGGACATAAAGGAGGCGATAGCCTTCGCGCTCTTCGGAGGGGTA
CCGAAGGAGCTGGAGGACGGAACTAGGATAAGGGGCGACATCCACGTCTTGATAATAGGGGACCCGGGCACGGCCAAGTC
CCAGCTCTTGCAGTACGCAGCTAGGATAGCGCCGAGGAGCGTTTACACGACCGGCAAGGGGAGCACCGCGGCGGGCCTCA
CGGCTGCAGTAGTTAGGGACAACATAACCGGCGAATACTACCTAGAGGCCGGCGCCTTAGTGTTGGCGGACGGCGGAGTG
GCGGTCATAGACGAGATAGACAAGATGAGGGAGGAGGACCGGTCGGCCATACACGAAGCTATGGAGCAGCAGACGGTCTC
CATAGCTAAGGCGGGAATAGTGGCCAAGCTCAACGCCCGCTGCGCGGTGCTCGCGGCGGGCAACCCCCGGTACGGCCGCT
ACGTGCCCGAGAGGTCCGTGGCGGAGAACATAAACTTGCCCCCGAGCATACTCTCGAGGTTCGACCTAATATTCGTCTTG
AGGGACGTCCCTGACCCGAAGAGGGATAGGAGGTTAGTAAGGTACATATTGAACGTACACAAGGAGGCCGACAAGATAGT
CCCGGAGATACCGGCGGACTTGCTGAAGAAGTACATAGCCTACGCGCGGAAGAGCGTGAAGCCCAAGCTCTCGGAGGCCG
CGGCGAGGATAATCGAGAACTTCTTCGTAGACTTGAGGAAGACCGCGGCCGAGAACCCGGAGATGGGCGTCCCCATAACA
GCGAGGCAGCTGGAAGCTCTGGTCAGGATGAGCGAGGCCCACGCGAAGATGGCCCTCAGAAGCGTGGTGGAGGAGGCCGA
CGCGATAGAGGCTGTCCGCATGATGCTCGCATTCTTAAGTACGGCTGGGGTCGACGTAGAGACCGGCAGGATAGACATAG
ATACCATATACGTGGGCGTTTCCAAGAGCAACCGCCAAAAGAGGCTGATATTGAAGGACATAATCAAAGAGAAGTTTAAG
GAGAAGGGGACTTGTGTGCACTTGAAGGAGGTAGTCAGGGAGGCGAGGAAGAGGGGTCTGAACGAGGAAGAGATAGAGCA
AATACTGACCCAGATGGTCAACCAAGGCGAGATATACGAGCCCAAGACCGCCTGTTACTCCCCGCTATAG

Upstream 100 bases:

>100_bases
GAAGTTCCCGTCAGCTTGAGGGAGAGGCTGACGCCGGAGGAGCAAGTGATCGCGGACGAGCTGGAGGGCGACATATCTCA
GTGGAAGAGGGTGGTGATCG

Downstream 100 bases:

>100_bases
CTCGATCTCCTCCTTGAGGTAGTAAGTCCTAACCCCGCAGCACTCCTCCACCCCTACGTAGCCCTCTGACACTAAGAACT
CCAAGTAAACCTTCAACCTT

Product: replicative DNA helicase Mcm

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MSEAGFLEEKLPVEERFREFLESYEVNGRVKYKDEIRNAVAERRASVVVDFTDVIEFDQELAEEIVENPLETLDKLDQVV
TEIASAFANKKYPMRVRFTNLPEKVRLRDLRERYVGKLVAFDGIVTKATNVKGKPKKLYFRCEACGTVFPVEQRGKYYQA
PTVCPNPECPKKTGPFTLLENHPKNEYVDWQLLVVQEKPEELPPGQMPRSIEVIVEGKDLVDVARPGDRVTVIGVLEAVP
NRVPKRGSMVVFDFKMIANNIEVSQKVLEDVHLSPEDVERIKELSKDPWIHKSIILSIAPAIYGHWDIKEAIAFALFGGV
PKELEDGTRIRGDIHVLIIGDPGTAKSQLLQYAARIAPRSVYTTGKGSTAAGLTAAVVRDNITGEYYLEAGALVLADGGV
AVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVAKLNARCAVLAAGNPRYGRYVPERSVAENINLPPSILSRFDLIFVL
RDVPDPKRDRRLVRYILNVHKEADKIVPEIPADLLKKYIAYARKSVKPKLSEAAARIIENFFVDLRKTAAENPEMGVPIT
ARQLEALVRMSEAHAKMALRSVVEEADAIEAVRMMLAFLSTAGVDVETGRIDIDTIYVGVSKSNRQKRLILKDIIKEKFK
EKGTCVHLKEVVREARKRGLNEEEIEQILTQMVNQGEIYEPKTACYSPL

Sequences:

>Translated_689_residues
MSEAGFLEEKLPVEERFREFLESYEVNGRVKYKDEIRNAVAERRASVVVDFTDVIEFDQELAEEIVENPLETLDKLDQVV
TEIASAFANKKYPMRVRFTNLPEKVRLRDLRERYVGKLVAFDGIVTKATNVKGKPKKLYFRCEACGTVFPVEQRGKYYQA
PTVCPNPECPKKTGPFTLLENHPKNEYVDWQLLVVQEKPEELPPGQMPRSIEVIVEGKDLVDVARPGDRVTVIGVLEAVP
NRVPKRGSMVVFDFKMIANNIEVSQKVLEDVHLSPEDVERIKELSKDPWIHKSIILSIAPAIYGHWDIKEAIAFALFGGV
PKELEDGTRIRGDIHVLIIGDPGTAKSQLLQYAARIAPRSVYTTGKGSTAAGLTAAVVRDNITGEYYLEAGALVLADGGV
AVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVAKLNARCAVLAAGNPRYGRYVPERSVAENINLPPSILSRFDLIFVL
RDVPDPKRDRRLVRYILNVHKEADKIVPEIPADLLKKYIAYARKSVKPKLSEAAARIIENFFVDLRKTAAENPEMGVPIT
ARQLEALVRMSEAHAKMALRSVVEEADAIEAVRMMLAFLSTAGVDVETGRIDIDTIYVGVSKSNRQKRLILKDIIKEKFK
EKGTCVHLKEVVREARKRGLNEEEIEQILTQMVNQGEIYEPKTACYSPL
>Mature_688_residues
SEAGFLEEKLPVEERFREFLESYEVNGRVKYKDEIRNAVAERRASVVVDFTDVIEFDQELAEEIVENPLETLDKLDQVVT
EIASAFANKKYPMRVRFTNLPEKVRLRDLRERYVGKLVAFDGIVTKATNVKGKPKKLYFRCEACGTVFPVEQRGKYYQAP
TVCPNPECPKKTGPFTLLENHPKNEYVDWQLLVVQEKPEELPPGQMPRSIEVIVEGKDLVDVARPGDRVTVIGVLEAVPN
RVPKRGSMVVFDFKMIANNIEVSQKVLEDVHLSPEDVERIKELSKDPWIHKSIILSIAPAIYGHWDIKEAIAFALFGGVP
KELEDGTRIRGDIHVLIIGDPGTAKSQLLQYAARIAPRSVYTTGKGSTAAGLTAAVVRDNITGEYYLEAGALVLADGGVA
VIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVAKLNARCAVLAAGNPRYGRYVPERSVAENINLPPSILSRFDLIFVLR
DVPDPKRDRRLVRYILNVHKEADKIVPEIPADLLKKYIAYARKSVKPKLSEAAARIIENFFVDLRKTAAENPEMGVPITA
RQLEALVRMSEAHAKMALRSVVEEADAIEAVRMMLAFLSTAGVDVETGRIDIDTIYVGVSKSNRQKRLILKDIIKEKFKE
KGTCVHLKEVVREARKRGLNEEEIEQILTQMVNQGEIYEPKTACYSPL

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33356547, Length=664, Percent_Identity=37.5, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI33469919, Length=623, Percent_Identity=37.8812199036918, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI33469917, Length=623, Percent_Identity=37.8812199036918, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI23510448, Length=710, Percent_Identity=35.0704225352113, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI33469968, Length=661, Percent_Identity=36.0060514372163, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI19923727, Length=752, Percent_Identity=32.8457446808511, Blast_Score=349, Evalue=5e-96,
Organism=Homo sapiens, GI7427519, Length=654, Percent_Identity=35.7798165137615, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI33469924, Length=746, Percent_Identity=32.9758713136729, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI6631095, Length=645, Percent_Identity=35.8139534883721, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI33469922, Length=478, Percent_Identity=41.0041841004184, Blast_Score=330, Evalue=4e-90,
Organism=Homo sapiens, GI310115110, Length=225, Percent_Identity=42.6666666666667, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI310128402, Length=225, Percent_Identity=42.6666666666667, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI310119838, Length=225, Percent_Identity=42.6666666666667, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI23397546, Length=358, Percent_Identity=31.5642458100559, Blast_Score=154, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71997752, Length=625, Percent_Identity=42.08, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17508417, Length=585, Percent_Identity=37.9487179487179, Blast_Score=387, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17554306, Length=638, Percent_Identity=34.7962382445141, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562700, Length=638, Percent_Identity=36.833855799373, Blast_Score=352, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17562702, Length=607, Percent_Identity=36.4085667215816, Blast_Score=337, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71997563, Length=632, Percent_Identity=35.7594936708861, Blast_Score=328, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI71997571, Length=313, Percent_Identity=46.6453674121406, Blast_Score=251, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6325276, Length=731, Percent_Identity=32.96853625171, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323304, Length=663, Percent_Identity=34.2383107088989, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319448, Length=653, Percent_Identity=36.2940275650842, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319679, Length=662, Percent_Identity=33.2326283987915, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6320803, Length=477, Percent_Identity=38.9937106918239, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6321237, Length=325, Percent_Identity=47.6923076923077, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17137132, Length=607, Percent_Identity=40.8566721581549, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24645774, Length=682, Percent_Identity=35.3372434017595, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17137242, Length=651, Percent_Identity=36.7127496159754, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24639835, Length=644, Percent_Identity=36.9565217391304, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI17530827, Length=640, Percent_Identity=35.15625, Blast_Score=346, Evalue=4e-95,
Organism=Drosophila melanogaster, GI17647617, Length=551, Percent_Identity=37.3865698729583, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24647251, Length=479, Percent_Identity=27.5574112734864, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 77368; Mature: 77237

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAGFLEEKLPVEERFREFLESYEVNGRVKYKDEIRNAVAERRASVVVDFTDVIEFDQE
CCCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHEEEEHHHHHHHHHH
LAEEIVENPLETLDKLDQVVTEIASAFANKKYPMRVRFTNLPEKVRLRDLRERYVGKLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
FDGIVTKATNVKGKPKKLYFRCEACGTVFPVEQRGKYYQAPTVCPNPECPKKTGPFTLLE
HCCHHEECCCCCCCCCEEEEEEECCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCEEEEC
NHPKNEYVDWQLLVVQEKPEELPPGQMPRSIEVIVEGKDLVDVARPGDRVTVIGVLEAVP
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCEEEEEHHHHHH
NRVPKRGSMVVFDFKMIANNIEVSQKVLEDVHLSPEDVERIKELSKDPWIHKSIILSIAP
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
AIYGHWDIKEAIAFALFGGVPKELEDGTRIRGDIHVLIIGDPGTAKSQLLQYAARIAPRS
HHHCCCCHHHHHHHHHHCCCCHHHCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCC
VYTTGKGSTAAGLTAAVVRDNITGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEA
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
MEQQTVSIAKAGIVAKLNARCAVLAAGNPRYGRYVPERSVAENINLPPSILSRFDLIFVL
HHHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHH
RDVPDPKRDRRLVRYILNVHKEADKIVPEIPADLLKKYIAYARKSVKPKLSEAAARIIEN
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FFVDLRKTAAENPEMGVPITARQLEALVRMSEAHAKMALRSVVEEADAIEAVRMMLAFLS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGVDVETGRIDIDTIYVGVSKSNRQKRLILKDIIKEKFKEKGTCVHLKEVVREARKRGL
HCCCCEECCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCC
NEEEIEQILTQMVNQGEIYEPKTACYSPL
CHHHHHHHHHHHHCCCCCCCCCHHCCCCC
>Mature Secondary Structure 
SEAGFLEEKLPVEERFREFLESYEVNGRVKYKDEIRNAVAERRASVVVDFTDVIEFDQE
CCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHEEEEHHHHHHHHHH
LAEEIVENPLETLDKLDQVVTEIASAFANKKYPMRVRFTNLPEKVRLRDLRERYVGKLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
FDGIVTKATNVKGKPKKLYFRCEACGTVFPVEQRGKYYQAPTVCPNPECPKKTGPFTLLE
HCCHHEECCCCCCCCCEEEEEEECCCCCCCHHHCCCEEECCCCCCCCCCCCCCCCEEEEC
NHPKNEYVDWQLLVVQEKPEELPPGQMPRSIEVIVEGKDLVDVARPGDRVTVIGVLEAVP
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCEEEEEHHHHHH
NRVPKRGSMVVFDFKMIANNIEVSQKVLEDVHLSPEDVERIKELSKDPWIHKSIILSIAP
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
AIYGHWDIKEAIAFALFGGVPKELEDGTRIRGDIHVLIIGDPGTAKSQLLQYAARIAPRS
HHHCCCCHHHHHHHHHHCCCCHHHCCCCEEECEEEEEEECCCCCHHHHHHHHHHHHCCCC
VYTTGKGSTAAGLTAAVVRDNITGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEA
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
MEQQTVSIAKAGIVAKLNARCAVLAAGNPRYGRYVPERSVAENINLPPSILSRFDLIFVL
HHHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHH
RDVPDPKRDRRLVRYILNVHKEADKIVPEIPADLLKKYIAYARKSVKPKLSEAAARIIEN
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FFVDLRKTAAENPEMGVPITARQLEALVRMSEAHAKMALRSVVEEADAIEAVRMMLAFLS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGVDVETGRIDIDTIYVGVSKSNRQKRLILKDIIKEKFKEKGTCVHLKEVVREARKRGL
HCCCCEECCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCC
NEEEIEQILTQMVNQGEIYEPKTACYSPL
CHHHHHHHHHHHHCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]