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The map label for this gene is cdc6-2 [H]

Identifier: 156938082

GI number: 156938082

Start: 1150318

End: 1151592

Strand: Direct

Name: cdc6-2 [H]

Synonym: Igni_1295

Alternate gene names: 156938082

Gene position: 1150318-1151592 (Clockwise)

Preceding gene: 156938081

Following gene: 156938083

Centisome position: 88.65

GC content: 53.18

Gene sequence:

>1275_bases
GTGAGCAGCGAGCTCTTCGACGAAATATACTCGGGGGGTCACAGGGTCATAAAGAACGAGGAGCTCCTGCACCCGGACAC
AGTGCCCCCTAGAATGCCCCACAGGGAGGAGGAACTCAAGAAGTTGGCCTACCTCTTCATGTCCTTGGTTAAGGAACCCG
GAGAGACCTTCAACTTCGCGGTTATATCGGGGAAGCAAGGGGTAGGCAAGACCCACTCCACAATCTTCTTCTACGAGCAC
GGACTCGCTAAACATTTAAAAGAGAAACAAGGAAAAGAGATAATACTGGCCCATGTGAACTGCTTCAAGAACAGCACTTT
GAACTCCATCTTGGCCACGGTATTAAACAGCATGCTGAGGGTCCCTCAGCCCGCCCGGGGGCTCTCGCCCAAGGAGCAGC
TGGACATAATTATGAATAGATTAGAGAGGAAGGATCGCTACATGCTCTTGGTCCTCGACGACTTCCACGTGGCCCTCCAG
AGGCAAGGCGAGTCCTTGACCAACTTCTTCGTCCGCATGTACGAGGACTCCGAGTACAAGAAGAAGAGGGTCCACGTCGT
TTTCATAGTTAGAGATTTTGATGTTATGGAGAGGTACTTAAGCGATCAAAAGGCTAAACTTAACTTGAAGAGTCGCCACA
TACACTTCGACCCCTACACGAGCTCTCAACTCTTCGACATTCTGGAAGACAGGGCGAAGCTTGCCCTCTACGAGAGCTCT
TACGACGAAGAAGTACTGTGGGAGATCTCTAGGATGATAGGTTACGACGTGAACCCCACTTTGCCCGACTCCGGGAGCGC
GCGGTTCGCTATAGAGATGTTATACTACGCCGCGAGGAACGCAGAAGAGCACGGGAGGAGTCAAATAACGATTGACGACG
TTAGGGTCGCTTGGGGGGTCTTGAGCGAGAGGGGAGGGGACTTGATTAGGATAAGCGAGGCGTTGGAAGACCTTAACGAC
CACCAGCTCTTGCTGCTCCTCTCCCTGTTGAACTTGTTGAAGCTGGACCCCGAGGGGGTGCCCATAGGTAGGATAGAGGA
GGAGTACAGGGAGGTGTGCGAAGTGGCGGGCGTGGAGCCTAGGAAGCACACCCAAGTCTACCAGTACGTGACGGACATGG
AGAAGAAAGGCATCGTAGACAGGATCGTGGGTAAGGTGAAGAACTCAAAGGGGAGGTCCTCCATAATAAGCGTGAGGTAC
CCTCCGGACGCCATGAGGAGGAGAGTCCTCGAGATACTTAAGAGGAGGGGGTACAACGTTGCGCATCTCGCGTGA

Upstream 100 bases:

>100_bases
GAATTGGTTTAAAAAATTTTTCGTTATTCGCGGGAGCGAAAGTTTTGTGTATACACTGTTGGTGTAAAAACTTTCGAGAG
GTAACTAAAGGGGGAGCGGG

Downstream 100 bases:

>100_bases
AATACTGAATAGGCCGACTATGTTAAAGGCGCTCATAGTGTTAAAGGACAGCGGCCCGATGACCCTAAGTGCCTTGAGCC
GCGCGCTCGGCACAAACAAG

Product: ORC complex protein Cdc6/Orc1

Products: NA

Alternate protein names: CDC6 homolog 2 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSSELFDEIYSGGHRVIKNEELLHPDTVPPRMPHREEELKKLAYLFMSLVKEPGETFNFAVISGKQGVGKTHSTIFFYEH
GLAKHLKEKQGKEIILAHVNCFKNSTLNSILATVLNSMLRVPQPARGLSPKEQLDIIMNRLERKDRYMLLVLDDFHVALQ
RQGESLTNFFVRMYEDSEYKKKRVHVVFIVRDFDVMERYLSDQKAKLNLKSRHIHFDPYTSSQLFDILEDRAKLALYESS
YDEEVLWEISRMIGYDVNPTLPDSGSARFAIEMLYYAARNAEEHGRSQITIDDVRVAWGVLSERGGDLIRISEALEDLND
HQLLLLLSLLNLLKLDPEGVPIGRIEEEYREVCEVAGVEPRKHTQVYQYVTDMEKKGIVDRIVGKVKNSKGRSSIISVRY
PPDAMRRRVLEILKRRGYNVAHLA

Sequences:

>Translated_424_residues
MSSELFDEIYSGGHRVIKNEELLHPDTVPPRMPHREEELKKLAYLFMSLVKEPGETFNFAVISGKQGVGKTHSTIFFYEH
GLAKHLKEKQGKEIILAHVNCFKNSTLNSILATVLNSMLRVPQPARGLSPKEQLDIIMNRLERKDRYMLLVLDDFHVALQ
RQGESLTNFFVRMYEDSEYKKKRVHVVFIVRDFDVMERYLSDQKAKLNLKSRHIHFDPYTSSQLFDILEDRAKLALYESS
YDEEVLWEISRMIGYDVNPTLPDSGSARFAIEMLYYAARNAEEHGRSQITIDDVRVAWGVLSERGGDLIRISEALEDLND
HQLLLLLSLLNLLKLDPEGVPIGRIEEEYREVCEVAGVEPRKHTQVYQYVTDMEKKGIVDRIVGKVKNSKGRSSIISVRY
PPDAMRRRVLEILKRRGYNVAHLA
>Mature_423_residues
SSELFDEIYSGGHRVIKNEELLHPDTVPPRMPHREEELKKLAYLFMSLVKEPGETFNFAVISGKQGVGKTHSTIFFYEHG
LAKHLKEKQGKEIILAHVNCFKNSTLNSILATVLNSMLRVPQPARGLSPKEQLDIIMNRLERKDRYMLLVLDDFHVALQR
QGESLTNFFVRMYEDSEYKKKRVHVVFIVRDFDVMERYLSDQKAKLNLKSRHIHFDPYTSSQLFDILEDRAKLALYESSY
DEEVLWEISRMIGYDVNPTLPDSGSARFAIEMLYYAARNAEEHGRSQITIDDVRVAWGVLSERGGDLIRISEALEDLNDH
QLLLLLSLLNLLKLDPEGVPIGRIEEEYREVCEVAGVEPRKHTQVYQYVTDMEKKGIVDRIVGKVKNSKGRSSIISVRYP
PDAMRRRVLEILKRRGYNVAHLA

Specific function: Might be involved in the initiation of DNA replication. Binds both single-strand and double-strand DNA. Has a weak ATPase activity. Strongly inhibits the ATPase and DNA helicase activity of the MCM protein [H]

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family [H]

Homologues:

Organism=Drosophila melanogaster, GI21355681, Length=401, Percent_Identity=23.1920199501247, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C [H]

EC number: NA

Molecular weight: Translated: 49005; Mature: 48874

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSELFDEIYSGGHRVIKNEELLHPDTVPPRMPHREEELKKLAYLFMSLVKEPGETFNFA
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VISGKQGVGKTHSTIFFYEHGLAKHLKEKQGKEIILAHVNCFKNSTLNSILATVLNSMLR
EEECCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHC
VPQPARGLSPKEQLDIIMNRLERKDRYMLLVLDDFHVALQRQGESLTNFFVRMYEDSEYK
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHCCCCHH
KKRVHVVFIVRDFDVMERYLSDQKAKLNLKSRHIHFDPYTSSQLFDILEDRAKLALYESS
HCEEEEEEEEECHHHHHHHHCCCHHEECEECCEEEECCCCHHHHHHHHHHHHHEEEECCC
YDEEVLWEISRMIGYDVNPTLPDSGSARFAIEMLYYAARNAEEHGRSQITIDDVRVAWGV
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHH
LSERGGDLIRISEALEDLNDHQLLLLLSLLNLLKLDPEGVPIGRIEEEYREVCEVAGVEP
HHHCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
RKHTQVYQYVTDMEKKGIVDRIVGKVKNSKGRSSIISVRYPPDAMRRRVLEILKRRGYNV
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCE
AHLA
ECCC
>Mature Secondary Structure 
SSELFDEIYSGGHRVIKNEELLHPDTVPPRMPHREEELKKLAYLFMSLVKEPGETFNFA
CHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VISGKQGVGKTHSTIFFYEHGLAKHLKEKQGKEIILAHVNCFKNSTLNSILATVLNSMLR
EEECCCCCCCCCCEEEEEECCHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHC
VPQPARGLSPKEQLDIIMNRLERKDRYMLLVLDDFHVALQRQGESLTNFFVRMYEDSEYK
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHCCCCHH
KKRVHVVFIVRDFDVMERYLSDQKAKLNLKSRHIHFDPYTSSQLFDILEDRAKLALYESS
HCEEEEEEEEECHHHHHHHHCCCHHEECEECCEEEECCCCHHHHHHHHHHHHHEEEECCC
YDEEVLWEISRMIGYDVNPTLPDSGSARFAIEMLYYAARNAEEHGRSQITIDDVRVAWGV
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHH
LSERGGDLIRISEALEDLNDHQLLLLLSLLNLLKLDPEGVPIGRIEEEYREVCEVAGVEP
HHHCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
RKHTQVYQYVTDMEKKGIVDRIVGKVKNSKGRSSIISVRYPPDAMRRRVLEILKRRGYNV
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCE
AHLA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]