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The map label for this gene is gds [H]

Identifier: 156937956

GI number: 156937956

Start: 1039852

End: 1040835

Strand: Reverse

Name: gds [H]

Synonym: Igni_1168

Alternate gene names: 156937956

Gene position: 1040835-1039852 (Counterclockwise)

Preceding gene: 156937957

Following gene: 156937955

Centisome position: 80.22

GC content: 58.74

Gene sequence:

>984_bases
GTGGAAACGTTAACGCGCTACCTCAGCGAGTTCAGACCTCTGGTCGACAAGAAGATCATGGAAGTCCTAGAGGGGAGCCC
CAAGGAACTCTACGAGGCCGCGAGACACTTGCCCTCCAAGGGGGGCAAGAGGCTGAGGCCCGCCTTGGTCCTCTTGGTGA
ACAAGGCCCTCGGGGGCGAGGTGGAGGGCGCCTTGCCCGCCGCGGCCGCGGTGGAGCTCTTACACAACTTTACCCTGGTG
CACGACGACATAATGGATAGGGACGAGTTGAGGCGGGGGGTGCCCACGGTCCACGTCCTCTACGGGGAGTCCATGGCCAT
ACTCGCCGGCGACTTGCTCTACGCGAAGGCTTACGAGGCCTTGCTCCAGTCCCCCCAACCCCCGGACCTCGTAAAGGAGA
TGACGGAAGTGCTAACGTGGAGCGCCGTAACGGTCGCCGAGGGACAAGCCATGGACATGGAGTTCGAGAAGCGCTGGGAC
GTGACGGAGGAGGAGTACCTAGAGATGATAGAGAAGAAGACCGGCGCCCTCTTCGGCGCCTCCGCCGCGCTGGGGGCTTT
GACAGCAAACAAGAGGGAGGTTAAGGACCTCATGAAGGAGTTCGGCCTAATACTCGGGAAGGCCTTCCAAATAAAGGACG
ACGTACTCTCGCTGTTGGGAGACGAGAAGGTCACCGGGAAGCCGAAGTACAACGACCTGAGAGAGGGAAAGAAAACGATA
CTCGTGATATACGCATTAAGGAACTTGCCGAGGGACGAGGCCGAGAGGGTGAAGTCGGTCTTAGGTAGGGAAACTTCTTA
CGAGGCGTTGGAAGAGGTCGCTGAACTGATAAAGAGGTCCGGTGCCCTCGACTACGCAATGAAGCTCGCCGAAGAGTTCG
AGAAGAGGGCGTACGAGATATTGGAGACCGTGCGGTTCGAGGACGAGGAGGCAATGAGAGCGCTGAAAGAGCTCGTGGAC
TTTGCGGTTAAGAGGGAGTACTGA

Upstream 100 bases:

>100_bases
GATGAACGGCTTTTAGCGGTAAACGACCGGCTGGGATGACGGCTTCACGGACCGGTTGACCCCTTTTAAGATCCCGTTTC
CGCGGCCTAGGGGACCAGTC

Downstream 100 bases:

>100_bases
TGGACCCCTACAAGTTCCCCCGGCTGTTCGTGGAGGGCAAGGAAGGGGAGGAGTACGCCGTGGTGGAGGGCGACGAAGTA
GTTTTCGTTAAAGAGAAGGT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
METLTRYLSEFRPLVDKKIMEVLEGSPKELYEAARHLPSKGGKRLRPALVLLVNKALGGEVEGALPAAAAVELLHNFTLV
HDDIMDRDELRRGVPTVHVLYGESMAILAGDLLYAKAYEALLQSPQPPDLVKEMTEVLTWSAVTVAEGQAMDMEFEKRWD
VTEEEYLEMIEKKTGALFGASAALGALTANKREVKDLMKEFGLILGKAFQIKDDVLSLLGDEKVTGKPKYNDLREGKKTI
LVIYALRNLPRDEAERVKSVLGRETSYEALEEVAELIKRSGALDYAMKLAEEFEKRAYEILETVRFEDEEAMRALKELVD
FAVKREY

Sequences:

>Translated_327_residues
METLTRYLSEFRPLVDKKIMEVLEGSPKELYEAARHLPSKGGKRLRPALVLLVNKALGGEVEGALPAAAAVELLHNFTLV
HDDIMDRDELRRGVPTVHVLYGESMAILAGDLLYAKAYEALLQSPQPPDLVKEMTEVLTWSAVTVAEGQAMDMEFEKRWD
VTEEEYLEMIEKKTGALFGASAALGALTANKREVKDLMKEFGLILGKAFQIKDDVLSLLGDEKVTGKPKYNDLREGKKTI
LVIYALRNLPRDEAERVKSVLGRETSYEALEEVAELIKRSGALDYAMKLAEEFEKRAYEILETVRFEDEEAMRALKELVD
FAVKREY
>Mature_327_residues
METLTRYLSEFRPLVDKKIMEVLEGSPKELYEAARHLPSKGGKRLRPALVLLVNKALGGEVEGALPAAAAVELLHNFTLV
HDDIMDRDELRRGVPTVHVLYGESMAILAGDLLYAKAYEALLQSPQPPDLVKEMTEVLTWSAVTVAEGQAMDMEFEKRWD
VTEEEYLEMIEKKTGALFGASAALGALTANKREVKDLMKEFGLILGKAFQIKDDVLSLLGDEKVTGKPKYNDLREGKKTI
LVIYALRNLPRDEAERVKSVLGRETSYEALEEVAELIKRSGALDYAMKLAEEFEKRAYEILETVRFEDEEAMRALKELVD
FAVKREY

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=276, Percent_Identity=30.4347826086957, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI83700220, Length=276, Percent_Identity=30.4347826086957, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI50659086, Length=303, Percent_Identity=27.3927392739274, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1789578, Length=313, Percent_Identity=30.0319488817891, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786623, Length=254, Percent_Identity=35.0393700787402, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=310, Percent_Identity=26.1290322580645, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508563, Length=271, Percent_Identity=27.6752767527675, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325188, Length=217, Percent_Identity=29.4930875576037, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281365769, Length=259, Percent_Identity=32.046332046332, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24660002, Length=259, Percent_Identity=32.046332046332, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24651612, Length=293, Percent_Identity=24.9146757679181, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137582, Length=241, Percent_Identity=26.1410788381743, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 36842; Mature: 36842

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLTRYLSEFRPLVDKKIMEVLEGSPKELYEAARHLPSKGGKRLRPALVLLVNKALGGE
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
VEGALPAAAAVELLHNFTLVHDDIMDRDELRRGVPTVHVLYGESMAILAGDLLYAKAYEA
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LLQSPQPPDLVKEMTEVLTWSAVTVAEGQAMDMEFEKRWDVTEEEYLEMIEKKTGALFGA
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCHHHH
SAALGALTANKREVKDLMKEFGLILGKAFQIKDDVLSLLGDEKVTGKPKYNDLREGKKTI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHE
LVIYALRNLPRDEAERVKSVLGRETSYEALEEVAELIKRSGALDYAMKLAEEFEKRAYEI
EHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LETVRFEDEEAMRALKELVDFAVKREY
HHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METLTRYLSEFRPLVDKKIMEVLEGSPKELYEAARHLPSKGGKRLRPALVLLVNKALGGE
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
VEGALPAAAAVELLHNFTLVHDDIMDRDELRRGVPTVHVLYGESMAILAGDLLYAKAYEA
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LLQSPQPPDLVKEMTEVLTWSAVTVAEGQAMDMEFEKRWDVTEEEYLEMIEKKTGALFGA
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCHHHH
SAALGALTANKREVKDLMKEFGLILGKAFQIKDDVLSLLGDEKVTGKPKYNDLREGKKTI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHE
LVIYALRNLPRDEAERVKSVLGRETSYEALEEVAELIKRSGALDYAMKLAEEFEKRAYEI
EHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LETVRFEDEEAMRALKELVDFAVKREY
HHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]