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The map label for this gene is rnz

Identifier: 156937827

GI number: 156937827

Start: 925659

End: 926561

Strand: Reverse

Name: rnz

Synonym: Igni_1037

Alternate gene names: 156937827

Gene position: 926561-925659 (Counterclockwise)

Preceding gene: 156937828

Following gene: 156937826

Centisome position: 71.41

GC content: 61.02

Gene sequence:

>903_bases
TTGAAGAGGGCGAGGTTCGTAGTGCTGGGCAGCGGCGCCGCCTCCCCGGCCCCCGAGAGGGCCCTGCCAGCCCACTACTT
CGAGTACGAAGGGGTTGGGGCGCTCTTGGACTGCGGCGAGGGGACGCAGTTCCAGCTCATGAAGGCCAAGATAAGCTTCT
CGAGGATAAAGGTAGTCTTCGTCTCCCACCTCCACGGGGACCACGTCCTCGGCCTCCCGGGCCTGCTCCAGACCATGGCC
ATGGCCTCCAGGAGGGACGAGCTGCTGGTGATAGGACCCAAGGGGTTGAAGGACTTCCTCCTCTCGTCCTTTGAGCTCAC
TTACTTCTACCCCCCTTACCCGATAAAGGTAGTGGAAGTCCTTAGGGATGCAGAAATAACTTATAGGAACTTGAAGTTAA
AGGTGTTTCCAGTGAATCACACGGTCCCCGCCTTCGGCGTGTCGGTGGAGACCGCTTCCAAGAGGAAGGTGAGGGCAGAC
GTGTTGGAAAGGGAGGGGCTGCCCAAGAGGCTCTGGGGGAGGCTCCAGCGCGGGGAGGACGTGGTCTGGGAGGGGAGGGT
GTTCAAGTACGAGGACTTCACGTTCGAGGGCGAGAGGATAAAGGTGGTCTACAGCGGCGACACGGCTCCTTGCGAGAGGC
TGGTGGAAGAGGCCGAGGGGGCTGACTTATTGGTCCACGAGGCCACCTTCACCAAGGAGTTAAAGGAGGAGGCCCACGAC
AGGGGGCACTCCACCGCGGAGGACGCGGCGACGGCAGCGGCTAGGGCCGGGGTCAAGCAGCTCTTGATGGTCCACTTCTC
CGCTAGGTACAAGGACTTGAGGAGGCACTTGGAGGAGGCTAGGAGGGTCTTCCCCCGCTCCTACGCCGCGGAGGACTTAA
CTAAGGTGGTTATACTGAAGTGA

Upstream 100 bases:

>100_bases
AGGGTCCCCCTCCTTACCTTCTCCTCACCCCTCGGAGGAGGTGCATTCGGGCATCCCCCATAAGGGGGCCTTCCGCTCCC
CCTTTCAAAGGAAAGGGGCT

Downstream 100 bases:

>100_bases
GCGGTGCCCCCCGTGGACTTGGGGCTGGCGGGCAAGAGGGTCTTGGTCACGGCCTCCACTAAGGGCATAGGCCTCGCTGT
GGCGAGGGAGTTCCTAAAGG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKRARFVVLGSGAASPAPERALPAHYFEYEGVGALLDCGEGTQFQLMKAKISFSRIKVVFVSHLHGDHVLGLPGLLQTMA
MASRRDELLVIGPKGLKDFLLSSFELTYFYPPYPIKVVEVLRDAEITYRNLKLKVFPVNHTVPAFGVSVETASKRKVRAD
VLEREGLPKRLWGRLQRGEDVVWEGRVFKYEDFTFEGERIKVVYSGDTAPCERLVEEAEGADLLVHEATFTKELKEEAHD
RGHSTAEDAATAAARAGVKQLLMVHFSARYKDLRRHLEEARRVFPRSYAAEDLTKVVILK

Sequences:

>Translated_300_residues
MKRARFVVLGSGAASPAPERALPAHYFEYEGVGALLDCGEGTQFQLMKAKISFSRIKVVFVSHLHGDHVLGLPGLLQTMA
MASRRDELLVIGPKGLKDFLLSSFELTYFYPPYPIKVVEVLRDAEITYRNLKLKVFPVNHTVPAFGVSVETASKRKVRAD
VLEREGLPKRLWGRLQRGEDVVWEGRVFKYEDFTFEGERIKVVYSGDTAPCERLVEEAEGADLLVHEATFTKELKEEAHD
RGHSTAEDAATAAARAGVKQLLMVHFSARYKDLRRHLEEARRVFPRSYAAEDLTKVVILK
>Mature_300_residues
MKRARFVVLGSGAASPAPERALPAHYFEYEGVGALLDCGEGTQFQLMKAKISFSRIKVVFVSHLHGDHVLGLPGLLQTMA
MASRRDELLVIGPKGLKDFLLSSFELTYFYPPYPIKVVEVLRDAEITYRNLKLKVFPVNHTVPAFGVSVETASKRKVRAD
VLEREGLPKRLWGRLQRGEDVVWEGRVFKYEDFTFEGERIKVVYSGDTAPCERLVEEAEGADLLVHEATFTKELKEEAHD
RGHSTAEDAATAAARAGVKQLLMVHFSARYKDLRRHLEEARRVFPRSYAAEDLTKVVILK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=312, Percent_Identity=33.974358974359, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI260166619, Length=301, Percent_Identity=30.5647840531561, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI260166622, Length=301, Percent_Identity=30.5647840531561, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI145553959, Length=301, Percent_Identity=30.5647840531561, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI87082078, Length=302, Percent_Identity=33.112582781457, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71985808, Length=285, Percent_Identity=25.9649122807018, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71985814, Length=285, Percent_Identity=25.9649122807018, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24652403, Length=321, Percent_Identity=25.5451713395639, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_IGNH4 (A8ABB4)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435623.1
- ProteinModelPortal:   A8ABB4
- SMR:   A8ABB4
- STRING:   A8ABB4
- GeneID:   5562748
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1037
- eggNOG:   arNOG04942
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK883695
- BioCyc:   IHOS453591:IGNI_1037-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 33801; Mature: 33801

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRARFVVLGSGAASPAPERALPAHYFEYEGVGALLDCGEGTQFQLMKAKISFSRIKVVF
CCCEEEEEEECCCCCCCCCCCCCCHHEEECCCCEEEECCCCCEEEEEEEHHHHHHEEEEE
VSHLHGDHVLGLPGLLQTMAMASRRDELLVIGPKGLKDFLLSSFELTYFYPPYPIKVVEV
EEECCCCCEECCHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEEECCCCHHHHHH
LRDAEITYRNLKLKVFPVNHTVPAFGVSVETASKRKVRADVLEREGLPKRLWGRLQRGED
HHCCCEEEEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCC
VVWEGRVFKYEDFTFEGERIKVVYSGDTAPCERLVEEAEGADLLVHEATFTKELKEEAHD
EEECCEEEEEECCEECCCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
RGHSTAEDAATAAARAGVKQLLMVHFSARYKDLRRHLEEARRVFPRSYAAEDLTKVVILK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEC
>Mature Secondary Structure
MKRARFVVLGSGAASPAPERALPAHYFEYEGVGALLDCGEGTQFQLMKAKISFSRIKVVF
CCCEEEEEEECCCCCCCCCCCCCCHHEEECCCCEEEECCCCCEEEEEEEHHHHHHEEEEE
VSHLHGDHVLGLPGLLQTMAMASRRDELLVIGPKGLKDFLLSSFELTYFYPPYPIKVVEV
EEECCCCCEECCHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCEEEEECCCCHHHHHH
LRDAEITYRNLKLKVFPVNHTVPAFGVSVETASKRKVRADVLEREGLPKRLWGRLQRGED
HHCCCEEEEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCC
VVWEGRVFKYEDFTFEGERIKVVYSGDTAPCERLVEEAEGADLLVHEATFTKELKEEAHD
EEECCEEEEEECCEECCCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
RGHSTAEDAATAAARAGVKQLLMVHFSARYKDLRRHLEEARRVFPRSYAAEDLTKVVILK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA