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The map label for this gene is thrS1 [H]

Identifier: 156937646

GI number: 156937646

Start: 756002

End: 757390

Strand: Direct

Name: thrS1 [H]

Synonym: Igni_0853

Alternate gene names: 156937646

Gene position: 756002-757390 (Clockwise)

Preceding gene: 156937640

Following gene: 156937647

Centisome position: 58.26

GC content: 53.56

Gene sequence:

>1389_bases
TTGAGCGTGAATCAGAAGGATCACATGGACTACGCCGTCGAGCTTGACATAGCCGTCAAGCCCACCACGCCGGTCCCCAA
CTTGGGCGCGGAGTACGGCTACTACGTGGGCGCGGGGAACCCGCTGTTCAGCGTCGGCGGAGGGGTCTTGAGGACCGCGC
TGAAGCACGTGTTGCACAAGTACCACGCGAGGAAGGGTTACTACGTCGTCGAGACTCCTATAATAGCTAGGACTACCCTC
TACGAGCTCACGGGTCACTTGAAGTTCTATAAGGAAAACATGTTCTTGTTGAACATAGAGGGCGACGAATACGCAATAAA
GCCTATGAATTGTCCCTTTCACGTCCTCATATTCATGAACTTGTTGCAGAAGTACTCATCTAAGGTAAAACTACCGTTCA
AGATATTCGAGACCGGGACTGTGCACCGCTACGAGATAGCGGGGGCCTTGAGGGGGCTGTTGAGGGTAAGGGCCTTCACC
CAAGACGACGCCCACTTGTTCTCTCCCGAGGAGCACGTCGAGGCATCTCTAATGGAAGTTTTCGAAATGATGAAGGACGT
GTACGAGAAACTCTTCTACATACCGGTTACCTCGGAGACAGTGAAGCTAAGGCTAAGCCTTTCGGATAAGAGTAAGATAG
GCGAGGAGTTCATGGGAGAACCAGAGATGTGGGAGTTCGCCGAAGAGAAGCTGTTCAAAGTGGCTGAGGAAGTGAAGAGG
AAGTACGGAATAGAATTCTTCGCCGAAGAGGGCGAGGCGGCCTTCTACGGCCCCAAGCTCGACGTGGTGGTCTACGAAGA
GGGAGGGAAGGAGTGGCAGATAGGCACTGCGCAGTTCGACTTCAACCTCCCAAAGCGCTTTAAACTACACGAACTGATTA
AAGAGACGCACGGCCTTGACGCGAACTTGTACATGATTCACAGGGCTCTGTTGGGCTCTCTCGAGAGGTTCTTGGGCATA
TACTTGGAGATGTTTAAGGGGAGGTTGCCCTTCTCGCTGGCTCCCTTACAGGTTTTGGTAATCGAGATAACTACGGGTAA
CGAGGAGGTTGACAAAAAGATAAAGGAGCTCAGCTCGAAAGTTGTGAACTCTTTAAAAGAAAACGAGATAAGGGTTGCAA
GCTTAACTAGCACCAAGACGCACTTGTCGAGGGACGTGAGGAAGGTGGAGTCGACCGTGAAGCCGCCTCTGATCTTGTAC
ATAGGCGGGAGGGAGGCCGAGGAGAGCGCGGTGGTCGCCAGGCCCTACGACCACAACAAGAGGAGGAGGGAGCAAATGAA
GTTGAAGGCTGACGAGGTCCTCAAGGTCATAGAGGAGATGGAGAGGGGAGTGGTGGAGCTGGCCGGGGCGCCGGTGAGGG
TGCCCGCGGACCCCTCCTACATGGTGTAA

Upstream 100 bases:

>100_bases
CCTCAACTTCTCGACCACCGGCTGCGGAACGACGCTCAGAGGTTTATTGCTTAAACAGCGACGCAGCTTGAATAGCGCTC
CGACGCCCTCGTGCGGGGGC

Downstream 100 bases:

>100_bases
CTCTTTCTTACCTCTCTTCGGAACGCCCCCGGGGCGAATTGGTTGAAGCTCACCTTCTTCGACGCCAGAGTATGGAAGTA
CGTGATCTCCGGGGTTTCTA

Product: Ser-tRNA(Thr) hydrolase

Products: NA

Alternate protein names: Threonine--tRNA ligase 1; ThrRS 1 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSVNQKDHMDYAVELDIAVKPTTPVPNLGAEYGYYVGAGNPLFSVGGGVLRTALKHVLHKYHARKGYYVVETPIIARTTL
YELTGHLKFYKENMFLLNIEGDEYAIKPMNCPFHVLIFMNLLQKYSSKVKLPFKIFETGTVHRYEIAGALRGLLRVRAFT
QDDAHLFSPEEHVEASLMEVFEMMKDVYEKLFYIPVTSETVKLRLSLSDKSKIGEEFMGEPEMWEFAEEKLFKVAEEVKR
KYGIEFFAEEGEAAFYGPKLDVVVYEEGGKEWQIGTAQFDFNLPKRFKLHELIKETHGLDANLYMIHRALLGSLERFLGI
YLEMFKGRLPFSLAPLQVLVIEITTGNEEVDKKIKELSSKVVNSLKENEIRVASLTSTKTHLSRDVRKVESTVKPPLILY
IGGREAEESAVVARPYDHNKRRREQMKLKADEVLKVIEEMERGVVELAGAPVRVPADPSYMV

Sequences:

>Translated_462_residues
MSVNQKDHMDYAVELDIAVKPTTPVPNLGAEYGYYVGAGNPLFSVGGGVLRTALKHVLHKYHARKGYYVVETPIIARTTL
YELTGHLKFYKENMFLLNIEGDEYAIKPMNCPFHVLIFMNLLQKYSSKVKLPFKIFETGTVHRYEIAGALRGLLRVRAFT
QDDAHLFSPEEHVEASLMEVFEMMKDVYEKLFYIPVTSETVKLRLSLSDKSKIGEEFMGEPEMWEFAEEKLFKVAEEVKR
KYGIEFFAEEGEAAFYGPKLDVVVYEEGGKEWQIGTAQFDFNLPKRFKLHELIKETHGLDANLYMIHRALLGSLERFLGI
YLEMFKGRLPFSLAPLQVLVIEITTGNEEVDKKIKELSSKVVNSLKENEIRVASLTSTKTHLSRDVRKVESTVKPPLILY
IGGREAEESAVVARPYDHNKRRREQMKLKADEVLKVIEEMERGVVELAGAPVRVPADPSYMV
>Mature_461_residues
SVNQKDHMDYAVELDIAVKPTTPVPNLGAEYGYYVGAGNPLFSVGGGVLRTALKHVLHKYHARKGYYVVETPIIARTTLY
ELTGHLKFYKENMFLLNIEGDEYAIKPMNCPFHVLIFMNLLQKYSSKVKLPFKIFETGTVHRYEIAGALRGLLRVRAFTQ
DDAHLFSPEEHVEASLMEVFEMMKDVYEKLFYIPVTSETVKLRLSLSDKSKIGEEFMGEPEMWEFAEEKLFKVAEEVKRK
YGIEFFAEEGEAAFYGPKLDVVVYEEGGKEWQIGTAQFDFNLPKRFKLHELIKETHGLDANLYMIHRALLGSLERFLGIY
LEMFKGRLPFSLAPLQVLVIEITTGNEEVDKKIKELSSKVVNSLKENEIRVASLTSTKTHLSRDVRKVESTVKPPLILYI
GGREAEESAVVARPYDHNKRRREQMKLKADEVLKVIEEMERGVVELAGAPVRVPADPSYMV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI20070344, Length=374, Percent_Identity=32.620320855615, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI38202255, Length=323, Percent_Identity=33.4365325077399, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI38570111, Length=384, Percent_Identity=32.2916666666667, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1788013, Length=374, Percent_Identity=36.096256684492, Blast_Score=212, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71984192, Length=398, Percent_Identity=31.6582914572864, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71984184, Length=398, Percent_Identity=31.6582914572864, Blast_Score=208, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6322112, Length=407, Percent_Identity=32.1867321867322, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6322654, Length=325, Percent_Identity=32.9230769230769, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24583839, Length=380, Percent_Identity=30.7894736842105, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24583842, Length=380, Percent_Identity=30.7894736842105, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574141, Length=380, Percent_Identity=30.7894736842105, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 52816; Mature: 52685

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNQKDHMDYAVELDIAVKPTTPVPNLGAEYGYYVGAGNPLFSVGGGVLRTALKHVLHK
CCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHH
YHARKGYYVVETPIIARTTLYELTGHLKFYKENMFLLNIEGDEYAIKPMNCPFHVLIFMN
HHCCCCEEEEECCHHHHHHHHHHHHHHEEEECCEEEEEECCCCEEEECCCCCHHHHHHHH
LLQKYSSKVKLPFKIFETGTVHRYEIAGALRGLLRVRAFTQDDAHLFSPEEHVEASLMEV
HHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FEMMKDVYEKLFYIPVTSETVKLRLSLSDKSKIGEEFMGEPEMWEFAEEKLFKVAEEVKR
HHHHHHHHHHHEEEEECCCEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KYGIEFFAEEGEAAFYGPKLDVVVYEEGGKEWQIGTAQFDFNLPKRFKLHELIKETHGLD
HHCCEEEECCCCEEEECCEEEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCC
ANLYMIHRALLGSLERFLGIYLEMFKGRLPFSLAPLQVLVIEITTGNEEVDKKIKELSSK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
VVNSLKENEIRVASLTSTKTHLSRDVRKVESTVKPPLILYIGGREAEESAVVARPYDHNK
HHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCHH
RRREQMKLKADEVLKVIEEMERGVVELAGAPVRVPADPSYMV
HHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCEECCCCCCCCC
>Mature Secondary Structure 
SVNQKDHMDYAVELDIAVKPTTPVPNLGAEYGYYVGAGNPLFSVGGGVLRTALKHVLHK
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHH
YHARKGYYVVETPIIARTTLYELTGHLKFYKENMFLLNIEGDEYAIKPMNCPFHVLIFMN
HHCCCCEEEEECCHHHHHHHHHHHHHHEEEECCEEEEEECCCCEEEECCCCCHHHHHHHH
LLQKYSSKVKLPFKIFETGTVHRYEIAGALRGLLRVRAFTQDDAHLFSPEEHVEASLMEV
HHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FEMMKDVYEKLFYIPVTSETVKLRLSLSDKSKIGEEFMGEPEMWEFAEEKLFKVAEEVKR
HHHHHHHHHHHEEEEECCCEEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KYGIEFFAEEGEAAFYGPKLDVVVYEEGGKEWQIGTAQFDFNLPKRFKLHELIKETHGLD
HHCCEEEECCCCEEEECCEEEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCC
ANLYMIHRALLGSLERFLGIYLEMFKGRLPFSLAPLQVLVIEITTGNEEVDKKIKELSSK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
VVNSLKENEIRVASLTSTKTHLSRDVRKVESTVKPPLILYIGGREAEESAVVARPYDHNK
HHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCHH
RRREQMKLKADEVLKVIEEMERGVVELAGAPVRVPADPSYMV
HHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]