Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 156937636

GI number: 156937636

Start: 747672

End: 748379

Strand: Direct

Name: purC [H]

Synonym: Igni_0843

Alternate gene names: 156937636

Gene position: 747672-748379 (Clockwise)

Preceding gene: 156937634

Following gene: 156937637

Centisome position: 57.62

GC content: 50.85

Gene sequence:

>708_bases
TTGAAGCTGATCTACGAGGGAAAGACAAAGAAAGTGTACGATATGGATGATAAGGTGCTGCTCAAATTCAAGGACGTTTT
CACCGCATTCGACGGCAAGAAGGTAGAAGAGGTAAAAGGTAAGGGAAAGGTAAACGCAGAGTTCACCGAGCTGTTGATGA
AGTACTTAGAACAGCACGGCGTTAAGACTCACTTCTTGAGCAGGAACGAAGACGAGATAGTTGCTATAAAAACCAAGCCT
CTTCCGTTAGAGTTCATCGTAAGGAACTACGCCTACGGTAGCTTGCTGAAGAGGCTCCCGATCCTAGAGAAGGGACAGAG
GTTGCTCACGCCGGTATTCGAGGTCCATTACAAGAGCGACGAGCTCCACGACCCCTTGCTCGCAGAGGACGACCCCGTAG
CGGCCGGGATAGTTTCCAAGGACGTAATGAAGACTATCAGGGAAACCACATTGAAGGTTAACGAGCTCCTCACAGAGCTC
TTCGAGAAGGCTGGGTTCAAGTTGATAGACTTCAAGGTGGAGTACGGAATAACGGAGGACGGAAGGGTCGTATTAATAGA
CGAGTTGAGTCCCGACTCCTTTAGGGCCCACAAGGGCGGCGAGGCTTACGACAAGGACTTGTTCCGCCAAGGCGCCAGCG
GCGAAGAAGTGTTGAAGAAGTACGTAGAGCTGTTAGAGGCTCTGAGGGAGGCGTTGGGCGTTGAATGA

Upstream 100 bases:

>100_bases
GTCGCTTCGAAGTCCGTGCACCGCGCGGTCATTCCCATCACGTTCGTAGTCGTGAGCAGACCTTAATTAGCGTCTACCTA
GAGCCGCTCTGGGAACTCTC

Downstream 100 bases:

>100_bases
ATACTTAGTCGAGGTCATAATTCGGAACAAGAGGGTCGCTAGGGACCCGGAGGGCGAGACCATAAAAAACGAACTGGTTA
GTAGGAGTTCCCTCGCGGAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKLIYEGKTKKVYDMDDKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHGVKTHFLSRNEDEIVAIKTKP
LPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKSDELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTEL
FEKAGFKLIDFKVEYGITEDGRVVLIDELSPDSFRAHKGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE

Sequences:

>Translated_235_residues
MKLIYEGKTKKVYDMDDKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHGVKTHFLSRNEDEIVAIKTKP
LPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKSDELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTEL
FEKAGFKLIDFKVEYGITEDGRVVLIDELSPDSFRAHKGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE
>Mature_235_residues
MKLIYEGKTKKVYDMDDKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHGVKTHFLSRNEDEIVAIKTKP
LPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKSDELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTEL
FEKAGFKLIDFKVEYGITEDGRVVLIDELSPDSFRAHKGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=222, Percent_Identity=29.7297297297297, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5453539, Length=222, Percent_Identity=29.7297297297297, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI119220559, Length=229, Percent_Identity=28.3842794759825, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=38.655462184874, Blast_Score=141, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17531275, Length=244, Percent_Identity=30.327868852459, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI18860083, Length=225, Percent_Identity=34.2222222222222, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583917, Length=210, Percent_Identity=32.8571428571429, Blast_Score=124, Evalue=7e-29,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26829; Mature: 26829

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYEGKTKKVYDMDDKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHG
CCEEECCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCC
VKTHFLSRNEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKSD
CEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCC
ELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGITED
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCC
GRVVLIDELSPDSFRAHKGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE
CCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLIYEGKTKKVYDMDDKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHG
CCEEECCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCC
VKTHFLSRNEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKSD
CEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCC
ELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGITED
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCC
GRVVLIDELSPDSFRAHKGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE
CCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA