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The map label for this gene is mvk [H]

Identifier: 156937551

GI number: 156937551

Start: 680638

End: 681603

Strand: Direct

Name: mvk [H]

Synonym: Igni_0758

Alternate gene names: 156937551

Gene position: 680638-681603 (Clockwise)

Preceding gene: 156937549

Following gene: 156937552

Centisome position: 52.46

GC content: 55.28

Gene sequence:

>966_bases
TTGAGCGTCTCGGCTAGAGCGCCAACCAAAGTTACCTTGTTCGGGGAACACTCAGTAGTCTACGGCAAGCCGGCCATAGT
ATTCTCTATGCCGATTTACATAAATGTGAAGCTGAGCCTCAGCGACGATCTAATGGTAATAACTGGCCCTGTGAGCCTTA
GAAGCGTAGATTTAGTGATTTCCAAGGACAAAATAGAGGTCGGCGACTTGGTGAGGAAACAAATGGAGAAGTACGTTTCA
TACGTCGTTGAAGCCTTGCAAACCATTGGGGTGGAAGGCGCGAGGGTGGAGATAGAGTCGCCCATGCCGGTGGGCGCGGG
AGTCGGCACCAGCGCGGCAGTAACTGTCGGTACGATAGCGGCGGCGTGTGCCCTAAAGAGGTGCGGGCTGAACAAGGAGG
GAATCGCCAAGCTCGCTTGGGAGGTCGAAAAGAAGGTTCAAGGGAAGGCCAGCCCTATGGATACTTTCGCTTCGGCCTTG
GGCGGCGTTTTATGGATAGAGAAGGAGGACAGCGGGTGGAAAATAGAGCGGTTAAGCGTGGACCAGCTCCCGCTAGTCGT
CGGGATTTTTGAGAAGAGGAAGACGACAGCTGAGCTCGTGAGGGAAGTGGCCTTAAAGGTTCAACGATCCGAGATCTATA
AGGACATAATCGAGCTTATGGGAAAAATAGCCAGGGAAGCCCGTGAGGCCTTGATCAAGGGAGACCTCAAGGAGCTGGGG
GAGCTTATGAAGCTAAACAACGCCATGCTCGAGGCGTTAGGACTGGTGACCAAAGAAGTATCGAATGCGATACACGCGGC
CGAGTTAGCTGGGGCTTACGGCGCGAAAGCGTCGGGCGCGGGGAGCGGCGGGGCAGTCGTAGCGCTGGCCGAGGACGTTA
AAGCGGTGAGGGCAGCGCTCTTGGCCTCCGGGGCCAAGAAGGTCTTCATCGTAGAGAACCCCTCCCGAGGTGTCGAACTT
ATATAG

Upstream 100 bases:

>100_bases
TGAAGGGAAGCTTCTTCTGAGGTGCGCTCAACTCCCTAAAACCCCGCGCAACTCAGCATTACAAAAATAAAAAGTCTAAT
AGAGTGGCTTCGGGCAAAAT

Downstream 100 bases:

>100_bases
ATATCGCTATATTTACGCCGTTTTTAAAAACCAGACGGGTGAGCAAGACACGGGAAGGGCGTCATGAAGAAAACCTCACT
ATTCCTCCTCGCGCTCCTAG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSVSARAPTKVTLFGEHSVVYGKPAIVFSMPIYINVKLSLSDDLMVITGPVSLRSVDLVISKDKIEVGDLVRKQMEKYVS
YVVEALQTIGVEGARVEIESPMPVGAGVGTSAAVTVGTIAAACALKRCGLNKEGIAKLAWEVEKKVQGKASPMDTFASAL
GGVLWIEKEDSGWKIERLSVDQLPLVVGIFEKRKTTAELVREVALKVQRSEIYKDIIELMGKIAREAREALIKGDLKELG
ELMKLNNAMLEALGLVTKEVSNAIHAAELAGAYGAKASGAGSGGAVVALAEDVKAVRAALLASGAKKVFIVENPSRGVEL
I

Sequences:

>Translated_321_residues
MSVSARAPTKVTLFGEHSVVYGKPAIVFSMPIYINVKLSLSDDLMVITGPVSLRSVDLVISKDKIEVGDLVRKQMEKYVS
YVVEALQTIGVEGARVEIESPMPVGAGVGTSAAVTVGTIAAACALKRCGLNKEGIAKLAWEVEKKVQGKASPMDTFASAL
GGVLWIEKEDSGWKIERLSVDQLPLVVGIFEKRKTTAELVREVALKVQRSEIYKDIIELMGKIAREAREALIKGDLKELG
ELMKLNNAMLEALGLVTKEVSNAIHAAELAGAYGAKASGAGSGGAVVALAEDVKAVRAALLASGAKKVFIVENPSRGVEL
I
>Mature_320_residues
SVSARAPTKVTLFGEHSVVYGKPAIVFSMPIYINVKLSLSDDLMVITGPVSLRSVDLVISKDKIEVGDLVRKQMEKYVSY
VVEALQTIGVEGARVEIESPMPVGAGVGTSAAVTVGTIAAACALKRCGLNKEGIAKLAWEVEKKVQGKASPMDTFASALG
GVLWIEKEDSGWKIERLSVDQLPLVVGIFEKRKTTAELVREVALKVQRSEIYKDIIELMGKIAREAREALIKGDLKELGE
LMKLNNAMLEALGLVTKEVSNAIHAAELAGAYGAKASGAGSGGAVVALAEDVKAVRAALLASGAKKVFIVENPSRGVELI

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34042; Mature: 33911

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSARAPTKVTLFGEHSVVYGKPAIVFSMPIYINVKLSLSDDLMVITGPVSLRSVDLVI
CCCCCCCCEEEEEEECCEEEECCCEEEEECCEEEEEEEEECCCEEEEECCCCEEEEEEEE
SKDKIEVGDLVRKQMEKYVSYVVEALQTIGVEGARVEIESPMPVGAGVGTSAAVTVGTIA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
AACALKRCGLNKEGIAKLAWEVEKKVQGKASPMDTFASALGGVLWIEKEDSGWKIERLSV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECC
DQLPLVVGIFEKRKTTAELVREVALKVQRSEIYKDIIELMGKIAREAREALIKGDLKELG
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ELMKLNNAMLEALGLVTKEVSNAIHAAELAGAYGAKASGAGSGGAVVALAEDVKAVRAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHH
LASGAKKVFIVENPSRGVELI
HHCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SVSARAPTKVTLFGEHSVVYGKPAIVFSMPIYINVKLSLSDDLMVITGPVSLRSVDLVI
CCCCCCCEEEEEEECCEEEECCCEEEEECCEEEEEEEEECCCEEEEECCCCEEEEEEEE
SKDKIEVGDLVRKQMEKYVSYVVEALQTIGVEGARVEIESPMPVGAGVGTSAAVTVGTIA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
AACALKRCGLNKEGIAKLAWEVEKKVQGKASPMDTFASALGGVLWIEKEDSGWKIERLSV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECC
DQLPLVVGIFEKRKTTAELVREVALKVQRSEIYKDIIELMGKIAREAREALIKGDLKELG
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ELMKLNNAMLEALGLVTKEVSNAIHAAELAGAYGAKASGAGSGGAVVALAEDVKAVRAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHH
LASGAKKVFIVENPSRGVELI
HHCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]