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The map label for this gene is pyrH

Identifier: 156937526

GI number: 156937526

Start: 659334

End: 659999

Strand: Direct

Name: pyrH

Synonym: Igni_0733

Alternate gene names: 156937526

Gene position: 659334-659999 (Clockwise)

Preceding gene: 156937525

Following gene: 156937529

Centisome position: 50.81

GC content: 55.71

Gene sequence:

>666_bases
TTGAAAACCTTGGTCTTGAAGATTTCAGGCAAGTTCGTGTCGCCTTATGACACGCCCCTCGTGGAGGGCTATGCCAAGAC
TCTAGAAGCGCTTAGGAGGAAGTACAAGCTAGCAGTGGTCGTGGGCGGGGGAAGCGTCGCTAGGAAGTACATAGAGCTGG
CCCCTCCCTCCAAAGGTCTCAAGGACTTGATAGGGATAGAGGTGTCAAGGCTGAACGCGTTGCTGCTTTCCATGCACACT
CCCTCGGCGAAGAAAGTAATCCCCAAGAGCGCCTCGGAGGTGCTCGAGCTCTGGGACGGCGAGGACATCCTCATAGTAGG
GGGCTTACAGCCCGGTCAATCCACGAACGCAGTCGCTCTGGTAGTGGCGGAGCTGGTGGGTGCTGACTTGGTGGTGAACG
CGACCACGGTGGACGCCGTGTACGACAAGCCCCCCTCGCAGCCTGGCGCTAAGAGAATAGAAAAAATAAAGGCCAGAGAG
CTCCAAAGGCTCTTAGAGAGTTTCGACTGGAAGAACGAGCCCGGAAGGTACGAGTTAATGGACTCCATCGCCTTGCAGAT
TGCAGAGAGGAGTAAGATTCCTATAGCTGTAATCTACGGCGGTGAGCCCGAGAGGATACCGTCTATAGTCGAGGAGGAGG
CGTGGGGAACCCTAATCTTACCGTAG

Upstream 100 bases:

>100_bases
GACGGGCAGAGTAGCCTACACGGCTCCAGCCAAGGAAATATTGAGTCACCCGGAGATCGGCAAGCTCTACTTGGGCTTGA
AGGGAGCGGGTGCTTGAACG

Downstream 100 bases:

>100_bases
CTCGGCAAGCACTTCCATTATGTCGCCCGTGCACGGCTTTTTGGGTTTCCTAAACTTGTTAGGGCCCTTCCTCCTAAGGG
CGGCACAGTCCTCTTGCTTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKTLVLKISGKFVSPYDTPLVEGYAKTLEALRRKYKLAVVVGGGSVARKYIELAPPSKGLKDLIGIEVSRLNALLLSMHT
PSAKKVIPKSASEVLELWDGEDILIVGGLQPGQSTNAVALVVAELVGADLVVNATTVDAVYDKPPSQPGAKRIEKIKARE
LQRLLESFDWKNEPGRYELMDSIALQIAERSKIPIAVIYGGEPERIPSIVEEEAWGTLILP

Sequences:

>Translated_221_residues
MKTLVLKISGKFVSPYDTPLVEGYAKTLEALRRKYKLAVVVGGGSVARKYIELAPPSKGLKDLIGIEVSRLNALLLSMHT
PSAKKVIPKSASEVLELWDGEDILIVGGLQPGQSTNAVALVVAELVGADLVVNATTVDAVYDKPPSQPGAKRIEKIKARE
LQRLLESFDWKNEPGRYELMDSIALQIAERSKIPIAVIYGGEPERIPSIVEEEAWGTLILP
>Mature_221_residues
MKTLVLKISGKFVSPYDTPLVEGYAKTLEALRRKYKLAVVVGGGSVARKYIELAPPSKGLKDLIGIEVSRLNALLLSMHT
PSAKKVIPKSASEVLELWDGEDILIVGGLQPGQSTNAVALVVAELVGADLVVNATTVDAVYDKPPSQPGAKRIEKIKARE
LQRLLESFDWKNEPGRYELMDSIALQIAERSKIPIAVIYGGEPERIPSIVEEEAWGTLILP

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_IGNH4 (A8AAG3)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435322.1
- ProteinModelPortal:   A8AAG3
- STRING:   A8AAG3
- GeneID:   5562469
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0733
- eggNOG:   arNOG05927
- HOGENOM:   HBG497552
- OMA:   AREYIEI
- BioCyc:   IHOS453591:IGNI_0733-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24023; Mature: 24023

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 44-44 BINDING 48-48 BINDING 62-62 BINDING 135-135 BINDING 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVLKISGKFVSPYDTPLVEGYAKTLEALRRKYKLAVVVGGGSVARKYIELAPPSKGL
CCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCCCH
KDLIGIEVSRLNALLLSMHTPSAKKVIPKSASEVLELWDGEDILIVGGLQPGQSTNAVAL
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCCEEEECCCCCCCCCCHHHH
VVAELVGADLVVNATTVDAVYDKPPSQPGAKRIEKIKARELQRLLESFDWKNEPGRYELM
HHHHHHCCCEEEECEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DSIALQIAERSKIPIAVIYGGEPERIPSIVEEEAWGTLILP
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKTLVLKISGKFVSPYDTPLVEGYAKTLEALRRKYKLAVVVGGGSVARKYIELAPPSKGL
CCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCCCH
KDLIGIEVSRLNALLLSMHTPSAKKVIPKSASEVLELWDGEDILIVGGLQPGQSTNAVAL
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCCEEEECCCCCCCCCCHHHH
VVAELVGADLVVNATTVDAVYDKPPSQPGAKRIEKIKARELQRLLESFDWKNEPGRYELM
HHHHHHCCCEEEECEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DSIALQIAERSKIPIAVIYGGEPERIPSIVEEEAWGTLILP
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA