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The map label for this gene is livH [H]

Identifier: 156937522

GI number: 156937522

Start: 655468

End: 656781

Strand: Direct

Name: livH [H]

Synonym: Igni_0729

Alternate gene names: 156937522

Gene position: 655468-656781 (Clockwise)

Preceding gene: 156937520

Following gene: 156937523

Centisome position: 50.52

GC content: 53.96

Gene sequence:

>1314_bases
TTGAGGACGAGGGCGTTAGCCAGCCTCATAGCACTCCTCATCGCCTTCTACGTTATCTGGAACGTAGCCCCCGTTTTGGG
CAACGTCTCTCAACAATTGCCTCAAGTGGTAGTGGACGCCATACTCTTGGGTAACTTGTACTTCCTCATCGCTGTCGGCA
TAACTCTGACCTACACGGTAGCCAAGTTCGCCAACTTCGCTCACGGAGACGTCGCGACGGCCGGCGCTTACGCCGCCTAT
CTGATATATAATTTCGCTATCATTGCTGGAATAATAAACAACATGGCGTTGTCCGTGGGCATAATATCCTTGCTTCTAGG
TATCCTTCTCATAGCCCTGTGGAAGATGGGGGGCAGCAGCGACGCGCTGGCCTTAGGCGTGCCCAGCGCCCTAACCGGCC
TTGCCATACTTTGGGCGTGCTTCTTACAAGCGAACTTGGTGGACTTGATTATTATTTCGGCCTCAGTTAGCGCGTTAACC
AGCGTGCTCTCCCACGTGTTGGTCTATCGCCCCTTGAGCAGGAGGGGGGCTACCTTAGTCCAACTAATGGTGGCCAGCAT
AGGCGTAGCCCTCTTCGTAAGATACTTCTTATACGAGCTCGCGTGGTACAGCAGGACGTACTTCAATACCGAGATAATGT
ACCAAAACTTCGGGATAAATTTAAATAGCTTCCAAGCGTGGTTAATGAACAATAGCTTGATAGTGGCTAACACGACGGCT
TCGTTCATATCCGACTACGTGCCGGCACTGAGCGTAGGGGCTCAAGGGATAAGGATAATCAAGGTGCCTTCCGTCGACTT
GCTGTTGAGTTTCCCCCAGCCGCTCTTGTCGTTCACGGACCTCCACGTGTGGAGTACGGTAACTGTGTTAGTAATACTCA
TAGCAATGACGACCATGTTCAAGAAGACTAAGATCGGAAAGGCTTGGAGGGCGGTGGCAGACAACCCGGTGCTGGCGGCC
GCGTGTGGAATAGACGTAGATTCGGTCATCAACTTAGCTTGGTTAGTCGCGGGAGCGCTGGCCGGGATAGGCGGCCTCTT
CTGGGCAATGCAGACGCAGATCTACCCCGAGCTGGGGTGGATGGTCCTCCTGAACGCGTTCGCAGTAGCGGTCTTGGGAG
GCCTCGGCAGCTTCTGGGGGACCTTCGTGGCCAGCTACTTGCTGGCCTTCGCGGAACAGTTGGGCGTCAGCATACTGGCG
TCCATCGACCCGCAACTGACCGGGTATAGGTTTATGATACCTTTCTCCGTGTTCCTCTTAGTTCTTTTCGTTAAGCCAGA
GGGGATAGCCGGCATTCGGAGGAGGAAGGCGTAA

Upstream 100 bases:

>100_bases
AACCTTCCCCGGCTCTCGCTAGGACGTCATGATTTAACTCTTATACCTATAAAGCAAAACGATATTAAAAGTTAAGCGAA
GTCGGGGCGGGCAAATAATA

Downstream 100 bases:

>100_bases
CTGGGGGTGTTGGGTATGGATAAGGTCGGCGCGCTCCTAGGGTTACTGATCTTGGGGGTCCTCGCGGCTCTGTTTTCGGT
AAGCCCGAGCTACGCTATTG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRTRALASLIALLIAFYVIWNVAPVLGNVSQQLPQVVVDAILLGNLYFLIAVGITLTYTVAKFANFAHGDVATAGAYAAY
LIYNFAIIAGIINNMALSVGIISLLLGILLIALWKMGGSSDALALGVPSALTGLAILWACFLQANLVDLIIISASVSALT
SVLSHVLVYRPLSRRGATLVQLMVASIGVALFVRYFLYELAWYSRTYFNTEIMYQNFGINLNSFQAWLMNNSLIVANTTA
SFISDYVPALSVGAQGIRIIKVPSVDLLLSFPQPLLSFTDLHVWSTVTVLVILIAMTTMFKKTKIGKAWRAVADNPVLAA
ACGIDVDSVINLAWLVAGALAGIGGLFWAMQTQIYPELGWMVLLNAFAVAVLGGLGSFWGTFVASYLLAFAEQLGVSILA
SIDPQLTGYRFMIPFSVFLLVLFVKPEGIAGIRRRKA

Sequences:

>Translated_437_residues
MRTRALASLIALLIAFYVIWNVAPVLGNVSQQLPQVVVDAILLGNLYFLIAVGITLTYTVAKFANFAHGDVATAGAYAAY
LIYNFAIIAGIINNMALSVGIISLLLGILLIALWKMGGSSDALALGVPSALTGLAILWACFLQANLVDLIIISASVSALT
SVLSHVLVYRPLSRRGATLVQLMVASIGVALFVRYFLYELAWYSRTYFNTEIMYQNFGINLNSFQAWLMNNSLIVANTTA
SFISDYVPALSVGAQGIRIIKVPSVDLLLSFPQPLLSFTDLHVWSTVTVLVILIAMTTMFKKTKIGKAWRAVADNPVLAA
ACGIDVDSVINLAWLVAGALAGIGGLFWAMQTQIYPELGWMVLLNAFAVAVLGGLGSFWGTFVASYLLAFAEQLGVSILA
SIDPQLTGYRFMIPFSVFLLVLFVKPEGIAGIRRRKA
>Mature_437_residues
MRTRALASLIALLIAFYVIWNVAPVLGNVSQQLPQVVVDAILLGNLYFLIAVGITLTYTVAKFANFAHGDVATAGAYAAY
LIYNFAIIAGIINNMALSVGIISLLLGILLIALWKMGGSSDALALGVPSALTGLAILWACFLQANLVDLIIISASVSALT
SVLSHVLVYRPLSRRGATLVQLMVASIGVALFVRYFLYELAWYSRTYFNTEIMYQNFGINLNSFQAWLMNNSLIVANTTA
SFISDYVPALSVGAQGIRIIKVPSVDLLLSFPQPLLSFTDLHVWSTVTVLVILIAMTTMFKKTKIGKAWRAVADNPVLAA
ACGIDVDSVINLAWLVAGALAGIGGLFWAMQTQIYPELGWMVLLNAFAVAVLGGLGSFWGTFVASYLLAFAEQLGVSILA
SIDPQLTGYRFMIPFSVFLLVLFVKPEGIAGIRRRKA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=143, Percent_Identity=33.5664335664336, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 47106; Mature: 47106

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRALASLIALLIAFYVIWNVAPVLGNVSQQLPQVVVDAILLGNLYFLIAVGITLTYTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKFANFAHGDVATAGAYAAYLIYNFAIIAGIINNMALSVGIISLLLGILLIALWKMGGSS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DALALGVPSALTGLAILWACFLQANLVDLIIISASVSALTSVLSHVLVYRPLSRRGATLV
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHH
QLMVASIGVALFVRYFLYELAWYSRTYFNTEIMYQNFGINLNSFQAWLMNNSLIVANTTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEECHH
SFISDYVPALSVGAQGIRIIKVPSVDLLLSFPQPLLSFTDLHVWSTVTVLVILIAMTTMF
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTKIGKAWRAVADNPVLAAACGIDVDSVINLAWLVAGALAGIGGLFWAMQTQIYPELGW
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVLLNAFAVAVLGGLGSFWGTFVASYLLAFAEQLGVSILASIDPQLTGYRFMIPFSVFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHH
VLFVKPEGIAGIRRRKA
HHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MRTRALASLIALLIAFYVIWNVAPVLGNVSQQLPQVVVDAILLGNLYFLIAVGITLTYTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKFANFAHGDVATAGAYAAYLIYNFAIIAGIINNMALSVGIISLLLGILLIALWKMGGSS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DALALGVPSALTGLAILWACFLQANLVDLIIISASVSALTSVLSHVLVYRPLSRRGATLV
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHH
QLMVASIGVALFVRYFLYELAWYSRTYFNTEIMYQNFGINLNSFQAWLMNNSLIVANTTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEECHH
SFISDYVPALSVGAQGIRIIKVPSVDLLLSFPQPLLSFTDLHVWSTVTVLVILIAMTTMF
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTKIGKAWRAVADNPVLAAACGIDVDSVINLAWLVAGALAGIGGLFWAMQTQIYPELGW
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVLLNAFAVAVLGGLGSFWGTFVASYLLAFAEQLGVSILASIDPQLTGYRFMIPFSVFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHH
VLFVKPEGIAGIRRRKA
HHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]