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The map label for this gene is ndk

Identifier: 156937518

GI number: 156937518

Start: 652492

End: 652935

Strand: Direct

Name: ndk

Synonym: Igni_0725

Alternate gene names: 156937518

Gene position: 652492-652935 (Clockwise)

Preceding gene: 156937517

Following gene: 156937519

Centisome position: 50.29

GC content: 54.5

Gene sequence:

>444_bases
GTGGAGAGAGAATTTGTAATGATCAAGCCGGACGGTGTCAAGAGGGGTCTCGTCGGCGAAATAATATCGAGGATCGAAAG
GAAGGGGCTCAAGATAGTGGCCATGAAGATGCTCAAGTTGGACAGGGAGATGGCAGAGAGGCTGTACGAAGAACACAAGG
GAAAGCCCTTCTTCGATGACTTGATAAGTTACGTGACCAGCGGCCCCGTGGTAGCGATGGTCGTCGAGGGACCCAACGCA
GTCGAAGTGATGAGGAGGATGATAGGAGACACCGACGGAGCCAAGGCCGCCCCCGGCACGATCAGAGGGGACTTCGCGCT
GAGTAAGGCGAGGAACGTAGTCCACGCGACCGACAGTCCCGAAAAGGTAGCTCGGGAAATGTCGATATTCTTCCGCGACG
ACGAGATCGTAGAGGGTTACGAGCTCTGTCACTCGATTTATTAA

Upstream 100 bases:

>100_bases
TTATGTGGTTCTGTAGCAGCAAGTGCTTCAAGAGCTTCAAGATGGGGAGAGACCCGAGGAAGCTTCCTTGGACCGCTAAG
TACGCCCGGAGGTGACAAAG

Downstream 100 bases:

>100_bases
CACTTTCTCTCCCCTGCACGCGGGAGTTTGGAGGACAGGGCTTTCTACTTGTTACTTAGAAAGTTTAGAGAGTTCGGCGT
GGACCCGAGCTGCGCGAGGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MEREFVMIKPDGVKRGLVGEIISRIERKGLKIVAMKMLKLDREMAERLYEEHKGKPFFDDLISYVTSGPVVAMVVEGPNA
VEVMRRMIGDTDGAKAAPGTIRGDFALSKARNVVHATDSPEKVAREMSIFFRDDEIVEGYELCHSIY

Sequences:

>Translated_147_residues
MEREFVMIKPDGVKRGLVGEIISRIERKGLKIVAMKMLKLDREMAERLYEEHKGKPFFDDLISYVTSGPVVAMVVEGPNA
VEVMRRMIGDTDGAKAAPGTIRGDFALSKARNVVHATDSPEKVAREMSIFFRDDEIVEGYELCHSIY
>Mature_147_residues
MEREFVMIKPDGVKRGLVGEIISRIERKGLKIVAMKMLKLDREMAERLYEEHKGKPFFDDLISYVTSGPVVAMVVEGPNA
VEVMRRMIGDTDGAKAAPGTIRGDFALSKARNVVHATDSPEKVAREMSIFFRDDEIVEGYELCHSIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=143, Percent_Identity=49.6503496503497, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392205, Length=143, Percent_Identity=49.6503496503497, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI4505409, Length=143, Percent_Identity=49.6503496503497, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392192, Length=143, Percent_Identity=49.6503496503497, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392203, Length=143, Percent_Identity=49.6503496503497, Blast_Score=151, Evalue=2e-37,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=51.8248175182482, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI38045913, Length=142, Percent_Identity=47.1830985915493, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4557797, Length=142, Percent_Identity=47.1830985915493, Blast_Score=144, Evalue=2e-35,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=47.7941176470588, Blast_Score=143, Evalue=6e-35,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI5031951, Length=145, Percent_Identity=33.1034482758621, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI148839372, Length=119, Percent_Identity=30.2521008403361, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=30.5970149253731, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=46.7153284671533, Blast_Score=134, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=48.1481481481481, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71995094, Length=130, Percent_Identity=35.3846153846154, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=47.4452554744526, Blast_Score=147, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=47.7941176470588, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=31.3432835820896, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645457, Length=134, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_IGNH4 (A8AAF5)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435314.1
- ProteinModelPortal:   A8AAF5
- SMR:   A8AAF5
- STRING:   A8AAF5
- GeneID:   5562530
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0725
- eggNOG:   arNOG07660
- HOGENOM:   HBG445152
- OMA:   DWADEGH
- BioCyc:   IHOS453591:IGNI_0725-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16550; Mature: 16550

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREFVMIKPDGVKRGLVGEIISRIERKGLKIVAMKMLKLDREMAERLYEEHKGKPFFDD
CCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LISYVTSGPVVAMVVEGPNAVEVMRRMIGDTDGAKAAPGTIRGDFALSKARNVVHATDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCH
EKVAREMSIFFRDDEIVEGYELCHSIY
HHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEREFVMIKPDGVKRGLVGEIISRIERKGLKIVAMKMLKLDREMAERLYEEHKGKPFFDD
CCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LISYVTSGPVVAMVVEGPNAVEVMRRMIGDTDGAKAAPGTIRGDFALSKARNVVHATDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEECCCCH
EKVAREMSIFFRDDEIVEGYELCHSIY
HHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA