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The map label for this gene is hemL

Identifier: 156937476

GI number: 156937476

Start: 615235

End: 616506

Strand: Direct

Name: hemL

Synonym: Igni_0683

Alternate gene names: 156937476

Gene position: 615235-616506 (Clockwise)

Preceding gene: 156937475

Following gene: 156937477

Centisome position: 47.42

GC content: 56.21

Gene sequence:

>1272_bases
GTGGACCGGTCGCTCGAGCTCTTCCAAATTGCAAAGAACTTGTTCCCGGGAGGGGTGAACAGCCCCATAAGGGCTGCTGT
AAAACCGTATCCGTTTTACGTAAAGAAGGCCAGCGGCGCCACTTTAGTGACTGTCGACGGCGTAGAACTAATTGACTACG
TACTGGGTTACGGCCCCTTAATACTAGGTCACATGCACCCTAAGGTCTTGGAAGCGGTGGAAGAGCAACTGAACAGAGGC
TGGTTGTACGGTACCCCCCACGAACTCGAGATAGAGCTAGCAAAGAAGATAGTGAGCCATTACCCCTCTATTGATATGGT
TAGGTTCGTGAATTCGGGGACTGAAGCGACGATGACCGCCATAAGGCTGGCCAGGGGTTTCACTAAGAAGAACAAAATAA
TCAAGTTCGACGGCTGCTACCACGGAGCACACGACTCCGTCTTAGTCAAGGCCGGCTCGGCCGTCTCGCACTTCGGGGTC
CCCGGCTCCGCCGGCGTCCCAGAGGAGGTGAGCAAGCTAACCTTGGTGGTGCCCTTCAACGACGTTGAAGCGGTAGAGAA
GGTGGCCAAGGAGAATCAAGACGACTTGGCCGCTATAATTGTTGAACCGGTGATGGGGAATGCCGGCGTAATCCCTCCCA
AGGAGGGCTTCCTCAAGGAGTTGAGGAGGATCGCCGATGAGACCGGCGCGCTCTTGATCTTCGACGAAGTGATCACCGGG
TACAGGCTGGGCTTGGGTGGCGCCCAAGCGAAGTTCGGCGTAGTACCGGATCTAACTACCTTAGGCAAGATAGTTGGCGG
AGGCTTCCCGGTAGGCGTCGTCGGAGGTAAGAGGGAGATCATGGAATACCTAACCCCCTCTGGCCCAGTGTTTAACGCCG
GCACGTTCAACGCGCACCCCGTAACTATGGCAGCGGGGCTCGCGACTATCAACGAACTCGAGAGGGGGTACGTCTACGAG
GTCGCCAACAGCGCGGCAGAAAAGGTGGCCAAGGCGTTGGAACAAGAAGCGGTGGCCAAGTTCGGGGGCGTAGTGCACAG
AGTGGCCAGCATGTTCCAGTGGTTCCCCGGGGTGGAAGAAGTTAACAACTACGCCGACGCCTTGAAGGCCAACAAGGAAA
TCTCGTTAAGGCTGCACGAGGAACTTCTGAAGAGAGGAGTATTCATAGCGCCGAGCTTGTTCGAAGCGTGGTTCACCTCC
GCGGCTCACGGGGAGGACGTGGTCAACAAGACGTTGGAGGCCTTATCCGAAGCGCTAAAGGTGATATCTTGA

Upstream 100 bases:

>100_bases
CGGAATAGCTATCGCGATAGTCATACTCTTCGCAATATAACAGCTTTTTTAGACACAGCGAAAATTAACGTCCCTTTGTT
CGAGATCCGTGGGTAAAAGC

Downstream 100 bases:

>100_bases
AAATCAAGATAGCCGCGCGCGGGAGCAAACTCAGCTTAAAGCAAGTATCCATGTTCACCTCCTACCTCCTCAAGTTCTTT
CCCGACTTGGAGTACGAAGT

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDRSLELFQIAKNLFPGGVNSPIRAAVKPYPFYVKKASGATLVTVDGVELIDYVLGYGPLILGHMHPKVLEAVEEQLNRG
WLYGTPHELEIELAKKIVSHYPSIDMVRFVNSGTEATMTAIRLARGFTKKNKIIKFDGCYHGAHDSVLVKAGSAVSHFGV
PGSAGVPEEVSKLTLVVPFNDVEAVEKVAKENQDDLAAIIVEPVMGNAGVIPPKEGFLKELRRIADETGALLIFDEVITG
YRLGLGGAQAKFGVVPDLTTLGKIVGGGFPVGVVGGKREIMEYLTPSGPVFNAGTFNAHPVTMAAGLATINELERGYVYE
VANSAAEKVAKALEQEAVAKFGGVVHRVASMFQWFPGVEEVNNYADALKANKEISLRLHEELLKRGVFIAPSLFEAWFTS
AAHGEDVVNKTLEALSEALKVIS

Sequences:

>Translated_423_residues
MDRSLELFQIAKNLFPGGVNSPIRAAVKPYPFYVKKASGATLVTVDGVELIDYVLGYGPLILGHMHPKVLEAVEEQLNRG
WLYGTPHELEIELAKKIVSHYPSIDMVRFVNSGTEATMTAIRLARGFTKKNKIIKFDGCYHGAHDSVLVKAGSAVSHFGV
PGSAGVPEEVSKLTLVVPFNDVEAVEKVAKENQDDLAAIIVEPVMGNAGVIPPKEGFLKELRRIADETGALLIFDEVITG
YRLGLGGAQAKFGVVPDLTTLGKIVGGGFPVGVVGGKREIMEYLTPSGPVFNAGTFNAHPVTMAAGLATINELERGYVYE
VANSAAEKVAKALEQEAVAKFGGVVHRVASMFQWFPGVEEVNNYADALKANKEISLRLHEELLKRGVFIAPSLFEAWFTS
AAHGEDVVNKTLEALSEALKVIS
>Mature_423_residues
MDRSLELFQIAKNLFPGGVNSPIRAAVKPYPFYVKKASGATLVTVDGVELIDYVLGYGPLILGHMHPKVLEAVEEQLNRG
WLYGTPHELEIELAKKIVSHYPSIDMVRFVNSGTEATMTAIRLARGFTKKNKIIKFDGCYHGAHDSVLVKAGSAVSHFGV
PGSAGVPEEVSKLTLVVPFNDVEAVEKVAKENQDDLAAIIVEPVMGNAGVIPPKEGFLKELRRIADETGALLIFDEVITG
YRLGLGGAQAKFGVVPDLTTLGKIVGGGFPVGVVGGKREIMEYLTPSGPVFNAGTFNAHPVTMAAGLATINELERGYVYE
VANSAAEKVAKALEQEAVAKFGGVVHRVASMFQWFPGVEEVNNYADALKANKEISLRLHEELLKRGVFIAPSLFEAWFTS
AAHGEDVVNKTLEALSEALKVIS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI13994255, Length=325, Percent_Identity=28.6153846153846, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557809, Length=312, Percent_Identity=28.8461538461538, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24119277, Length=346, Percent_Identity=27.7456647398844, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI37574042, Length=336, Percent_Identity=27.9761904761905, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442709, Length=305, Percent_Identity=29.5081967213115, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442705, Length=275, Percent_Identity=29.4545454545455, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=30.2631578947368, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=47.8468899521531, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789016, Length=351, Percent_Identity=30.7692307692308, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI145693181, Length=284, Percent_Identity=35.9154929577465, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788044, Length=266, Percent_Identity=35.3383458646617, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787560, Length=315, Percent_Identity=32.3809523809524, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789759, Length=320, Percent_Identity=30.625, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1786991, Length=344, Percent_Identity=27.906976744186, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=347, Percent_Identity=28.8184438040346, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=329, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=309, Percent_Identity=29.7734627831715, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=151, Percent_Identity=33.7748344370861, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=344, Percent_Identity=28.4883720930233, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=265, Percent_Identity=29.811320754717, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356575, Length=316, Percent_Identity=27.5316455696203, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357415, Length=292, Percent_Identity=29.1095890410959, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_IGNH4 (A8AAB3)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435272.1
- ProteinModelPortal:   A8AAB3
- SMR:   A8AAB3
- STRING:   A8AAB3
- GeneID:   5561840
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0683
- eggNOG:   arNOG04972
- HOGENOM:   HBG725944
- OMA:   NANIPFF
- BioCyc:   IHOS453591:IGNI_0683-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45539; Mature: 45539

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSLELFQIAKNLFPGGVNSPIRAAVKPYPFYVKKASGATLVTVDGVELIDYVLGYGPL
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHCCHHH
ILGHMHPKVLEAVEEQLNRGWLYGTPHELEIELAKKIVSHYPSIDMVRFVNSGTEATMTA
HHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
IRLARGFTKKNKIIKFDGCYHGAHDSVLVKAGSAVSHFGVPGSAGVPEEVSKLTLVVPFN
HHHHHCCHHCCCEEEEECCCCCCCCCEEEECCCHHHHCCCCCCCCCCHHHCCEEEEEECC
DVEAVEKVAKENQDDLAAIIVEPVMGNAGVIPPKEGFLKELRRIADETGALLIFDEVITG
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHH
YRLGLGGAQAKFGVVPDLTTLGKIVGGGFPVGVVGGKREIMEYLTPSGPVFNAGTFNAHP
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCEECCCCCCCCC
VTMAAGLATINELERGYVYEVANSAAEKVAKALEQEAVAKFGGVVHRVASMFQWFPGVEE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VNNYADALKANKEISLRLHEELLKRGVFIAPSLFEAWFTSAAHGEDVVNKTLEALSEALK
HHHHHHHHHCCCHHHHHHHHHHHHCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VIS
HCC
>Mature Secondary Structure
MDRSLELFQIAKNLFPGGVNSPIRAAVKPYPFYVKKASGATLVTVDGVELIDYVLGYGPL
CCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHCCHHH
ILGHMHPKVLEAVEEQLNRGWLYGTPHELEIELAKKIVSHYPSIDMVRFVNSGTEATMTA
HHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
IRLARGFTKKNKIIKFDGCYHGAHDSVLVKAGSAVSHFGVPGSAGVPEEVSKLTLVVPFN
HHHHHCCHHCCCEEEEECCCCCCCCCEEEECCCHHHHCCCCCCCCCCHHHCCEEEEEECC
DVEAVEKVAKENQDDLAAIIVEPVMGNAGVIPPKEGFLKELRRIADETGALLIFDEVITG
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHH
YRLGLGGAQAKFGVVPDLTTLGKIVGGGFPVGVVGGKREIMEYLTPSGPVFNAGTFNAHP
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCEECCCCCCCCC
VTMAAGLATINELERGYVYEVANSAAEKVAKALEQEAVAKFGGVVHRVASMFQWFPGVEE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VNNYADALKANKEISLRLHEELLKRGVFIAPSLFEAWFTSAAHGEDVVNKTLEALSEALK
HHHHHHHHHCCCHHHHHHHHHHHHCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VIS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA