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The map label for this gene is guaAB [H]

Identifier: 156937430

GI number: 156937430

Start: 573345

End: 574457

Strand: Direct

Name: guaAB [H]

Synonym: Igni_0637

Alternate gene names: 156937430

Gene position: 573345-574457 (Clockwise)

Preceding gene: 156937428

Following gene: 156937431

Centisome position: 44.19

GC content: 57.05

Gene sequence:

>1113_bases
GTGTTCAATGCGAACGACTTTATTAAGAAGAAGATAGAAGAGATAAGGGAACTGGTCGGGAAGGAAAAGGTTTTAGCGGC
CGTCAGCGGGGGCGTGGACTCCACCACGGCCGCTGCCCTCGCCTACAAGGCCTTGGGGCCGGAGCAGATAAAAGTGATAT
TCATTGACACGGGCTTCATGCGTAAGGGCGAGCCCGAGTGGGTCAAGAACGTCCTTAGAGACGTCATGCCGGTGGAAATA
GTGGACGCCAAAGAGCGCTTCTTCAACGCCGTCAAGGGCTTGAGTGACGCCGAGGAAAAGAGGAAAGCATTCAGAGAGGT
GTTTTACCAAGTAGTCTCGGAGGAGGCCAAGAAGTGGGGGGCGAGCTGGTTAGTCCAAGGGACCACCGCCCCAGACTGGA
TAGAAACCACTGGGGGGATCAAAACGCAACACAACGTCTTGGAACAGCTCGGAATAAACGTCAGGGAGAAGTGGGGCTTC
AAGCTGCTGGAGCCTTTGGTGGAGCTCTACAAAGACGAGGTGAGGGCGGTCGCTAGGGCCTTGGGGCTCCCGGAGGAGAT
AGCCTCCCGCCAACCCTTCCCGGGCCCGGGCTTGCTTGTGAGGATACCAGGCCTCGTTACCGAGGAGAAGCTAGAACTGC
TCAAAGAAGTTACCGAAGTGGTGGAGAAAGAGCTGGAGAGGTTCAAGCCCAGCCAGTACTTCGCGGCCATATGGGAGGAC
CGGCTCGGGCCGAAGGTGTCCGAGAGCCCCGAGGCCTACTTGTTCGAGGGGGTGAGGGCCACCGGGGTCAAAGGGGACAT
TCGCGCCTACGGCCCGGTGGCCCTACTCAAGGCCTTCGACTGGGAACGAGTGTACGACTACTGGAAGGAGATAATTCACA
AGAACAACGAAGTGACGCACGTAGTGGCGGAAGTGGGCGAGCGCGAGGAAGGGGAGTACACGATATCTATAAGGGCCGTC
TTGACGGACAACTTCATGACTGCCGACGTGCTCAAGCTGGATAGGGGAACGCTGGAGGAGATAGCTAAGAAGGTAATGAA
AGTTAGTCCCAAGATCAAGAGAGTGGTCTACGACGTGACCCCCAAGCCGCCCGCGACCATAGAGTACGAGTGA

Upstream 100 bases:

>100_bases
TGCGCCTCCCCTCGCGCTCGTGCGCGCTGATTCATACACTTTGTTGAGAGCTCGCAGTAAGGCTCATAGGTCCTTCCGGA
GCAGCCGCGAAGGGAAGTTC

Downstream 100 bases:

>100_bases
AGGGCTCGCCCGCGTTAGCTGCGTTCACCGGCCTCACCACACACCACCTCGCTCATCGCCTCGGCAATCAACACCCTCTT
CATCACTTCGGATGATAGGG

Product: GMP synthase (glutamine-hydrolyzing)

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MFNANDFIKKKIEEIRELVGKEKVLAAVSGGVDSTTAAALAYKALGPEQIKVIFIDTGFMRKGEPEWVKNVLRDVMPVEI
VDAKERFFNAVKGLSDAEEKRKAFREVFYQVVSEEAKKWGASWLVQGTTAPDWIETTGGIKTQHNVLEQLGINVREKWGF
KLLEPLVELYKDEVRAVARALGLPEEIASRQPFPGPGLLVRIPGLVTEEKLELLKEVTEVVEKELERFKPSQYFAAIWED
RLGPKVSESPEAYLFEGVRATGVKGDIRAYGPVALLKAFDWERVYDYWKEIIHKNNEVTHVVAEVGEREEGEYTISIRAV
LTDNFMTADVLKLDRGTLEEIAKKVMKVSPKIKRVVYDVTPKPPATIEYE

Sequences:

>Translated_370_residues
MFNANDFIKKKIEEIRELVGKEKVLAAVSGGVDSTTAAALAYKALGPEQIKVIFIDTGFMRKGEPEWVKNVLRDVMPVEI
VDAKERFFNAVKGLSDAEEKRKAFREVFYQVVSEEAKKWGASWLVQGTTAPDWIETTGGIKTQHNVLEQLGINVREKWGF
KLLEPLVELYKDEVRAVARALGLPEEIASRQPFPGPGLLVRIPGLVTEEKLELLKEVTEVVEKELERFKPSQYFAAIWED
RLGPKVSESPEAYLFEGVRATGVKGDIRAYGPVALLKAFDWERVYDYWKEIIHKNNEVTHVVAEVGEREEGEYTISIRAV
LTDNFMTADVLKLDRGTLEEIAKKVMKVSPKIKRVVYDVTPKPPATIEYE
>Mature_370_residues
MFNANDFIKKKIEEIRELVGKEKVLAAVSGGVDSTTAAALAYKALGPEQIKVIFIDTGFMRKGEPEWVKNVLRDVMPVEI
VDAKERFFNAVKGLSDAEEKRKAFREVFYQVVSEEAKKWGASWLVQGTTAPDWIETTGGIKTQHNVLEQLGINVREKWGF
KLLEPLVELYKDEVRAVARALGLPEEIASRQPFPGPGLLVRIPGLVTEEKLELLKEVTEVVEKELERFKPSQYFAAIWED
RLGPKVSESPEAYLFEGVRATGVKGDIRAYGPVALLKAFDWERVYDYWKEIIHKNNEVTHVVAEVGEREEGEYTISIRAV
LTDNFMTADVLKLDRGTLEEIAKKVMKVSPKIKRVVYDVTPKPPATIEYE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=343, Percent_Identity=33.5276967930029, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1788854, Length=373, Percent_Identity=35.9249329758713, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71992710, Length=359, Percent_Identity=30.9192200557103, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71992717, Length=359, Percent_Identity=30.9192200557103, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI133901714, Length=359, Percent_Identity=30.9192200557103, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323873, Length=384, Percent_Identity=33.0729166666667, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281365319, Length=345, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 41884; Mature: 41884

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNANDFIKKKIEEIRELVGKEKVLAAVSGGVDSTTAAALAYKALGPEQIKVIFIDTGFM
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCC
RKGEPEWVKNVLRDVMPVEIVDAKERFFNAVKGLSDAEEKRKAFREVFYQVVSEEAKKWG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ASWLVQGTTAPDWIETTGGIKTQHNVLEQLGINVREKWGFKLLEPLVELYKDEVRAVARA
CCEEEECCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHH
LGLPEEIASRQPFPGPGLLVRIPGLVTEEKLELLKEVTEVVEKELERFKPSQYFAAIWED
HCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RLGPKVSESPEAYLFEGVRATGVKGDIRAYGPVALLKAFDWERVYDYWKEIIHKNNEVTH
HCCCCCCCCCCHHHHCCCHHCCCCCCCHHCCHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
VVAEVGEREEGEYTISIRAVLTDNFMTADVLKLDRGTLEEIAKKVMKVSPKIKRVVYDVT
HHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHEEECC
PKPPATIEYE
CCCCCCCCCC
>Mature Secondary Structure
MFNANDFIKKKIEEIRELVGKEKVLAAVSGGVDSTTAAALAYKALGPEQIKVIFIDTGFM
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCC
RKGEPEWVKNVLRDVMPVEIVDAKERFFNAVKGLSDAEEKRKAFREVFYQVVSEEAKKWG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ASWLVQGTTAPDWIETTGGIKTQHNVLEQLGINVREKWGFKLLEPLVELYKDEVRAVARA
CCEEEECCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHH
LGLPEEIASRQPFPGPGLLVRIPGLVTEEKLELLKEVTEVVEKELERFKPSQYFAAIWED
HCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RLGPKVSESPEAYLFEGVRATGVKGDIRAYGPVALLKAFDWERVYDYWKEIIHKNNEVTH
HCCCCCCCCCCHHHHCCCHHCCCCCCCHHCCHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
VVAEVGEREEGEYTISIRAVLTDNFMTADVLKLDRGTLEEIAKKVMKVSPKIKRVVYDVT
HHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHEEECC
PKPPATIEYE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]