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The map label for this gene is pyrC [H]

Identifier: 156937389

GI number: 156937389

Start: 533760

End: 534911

Strand: Reverse

Name: pyrC [H]

Synonym: Igni_0596

Alternate gene names: 156937389

Gene position: 534911-533760 (Counterclockwise)

Preceding gene: 156937390

Following gene: 156937380

Centisome position: 41.23

GC content: 57.47

Gene sequence:

>1152_bases
GTGGTCGAGGCGACCCTCATCTCAGAAGGGGAGCGCTTGGCGGTGCGCGGCCCCTCGGCCGCTTGTGACTGTGAGACTTG
CCTCGAGATGAGGGGTACGATCGCCCTGCCCGGCATGGTCGACGCGCACGTGCACACGAGGGGCCTCATGTTGTCACACA
AGGAAGACCCCTTGACGGCCTCCCGGGCAGCGCTCAAGGGAGGGGTAGTTGCCATAGCCGACATGCCGAACACCTTACCC
AAGATAAACAATCTAGAAATATTGAAGAAAAGGTTGGAAGAGTTCAAGCGAACGTGTTTGGTCGACTGCTACCAGTACGC
CGGGGTCCCGGAAAGCCCGGAGGAGCTGAGGGCGATGTCTAAACACGTCGTCGGAGTGAAGGTGTATCCAGAGGACTACC
CTAACCTACACGTCTTGAGGAACTATGACGGTTTGATAGTGGTTCACCCCGAGCACCCCGCGTTCGTCAAGGAGAGCCCC
GACCCCGGCGAGAGGGGGCTCTCGAGGTCGCCCTTCGCTGAGCCGGCGGCTATGGAGCTGTTTAGGGGCTTCTCTAAAGT
TCACTTCACCCACGTAAGCACCCCGGAAGGGGCGAGAAAAGCCGAGGAAATGGGCTTTACGTTCGACGTAACGCCCCATC
ACATATTGTTAAACAACGAAGTAGAAAAGCTAAAAGGATGCGTCGCAAAGGTGAACCCTCCACTGCGGGACGAGCCGAGG
AGGGGGATGATGTTCGACATTTTCGTCAACAAGGACGTAATGATGGTAACCGACCACGCCCCTCACGCCGTGTGGGAGAA
GGAGCTTCCATTCTACGACTGTCCCCCGGGCTTCCCCGGGCTGGAGACCGCGCTGCCCTTGCTCTTAACTTTGTACAAGA
GGGGCATAATTTCCCTCAACAAGGTAGTGAGGAGCTACTCCGAGCTCCCCGCCAAGCTACTGGGCCTCTGGCCGGACTTG
GGGAGGCTGGAGACCGGTTCCTTGGCCTCCTTCACAGTGGTGGACGTAAACGAGAGGAGGAGGGTGGAGCCTTGGGAGTT
CGAGAGCAAAGCTAAGTACAGCCCCTTCGAGGGCATGAACCTCTGGGGAGAGGTAGTGGCAACCGTAGTGAGGGGAAAAA
TTAGGTACTTTAGTGGAAACTTCTATTACTGA

Upstream 100 bases:

>100_bases
ATCAAGCCCCGCGTGAGGGGGGTTAGCGCGGAAGAGGTAAAAGACGTTGGCGAAGGAGTGCGCAGTAGGCTACAAGGGGA
AGATATTTTATAAAGGAGAG

Downstream 100 bases:

>100_bases
GGCTGCTTTTAGGTTTGCTCTTTCTGCTTCTTCCTCTCCGGCTTCTCCTCCGGGTTTATGCCGGCCAAGGAAAGGGCGAC
ATCCTCCATTTCCTCCAACG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MVEATLISEGERLAVRGPSAACDCETCLEMRGTIALPGMVDAHVHTRGLMLSHKEDPLTASRAALKGGVVAIADMPNTLP
KINNLEILKKRLEEFKRTCLVDCYQYAGVPESPEELRAMSKHVVGVKVYPEDYPNLHVLRNYDGLIVVHPEHPAFVKESP
DPGERGLSRSPFAEPAAMELFRGFSKVHFTHVSTPEGARKAEEMGFTFDVTPHHILLNNEVEKLKGCVAKVNPPLRDEPR
RGMMFDIFVNKDVMMVTDHAPHAVWEKELPFYDCPPGFPGLETALPLLLTLYKRGIISLNKVVRSYSELPAKLLGLWPDL
GRLETGSLASFTVVDVNERRRVEPWEFESKAKYSPFEGMNLWGEVVATVVRGKIRYFSGNFYY

Sequences:

>Translated_383_residues
MVEATLISEGERLAVRGPSAACDCETCLEMRGTIALPGMVDAHVHTRGLMLSHKEDPLTASRAALKGGVVAIADMPNTLP
KINNLEILKKRLEEFKRTCLVDCYQYAGVPESPEELRAMSKHVVGVKVYPEDYPNLHVLRNYDGLIVVHPEHPAFVKESP
DPGERGLSRSPFAEPAAMELFRGFSKVHFTHVSTPEGARKAEEMGFTFDVTPHHILLNNEVEKLKGCVAKVNPPLRDEPR
RGMMFDIFVNKDVMMVTDHAPHAVWEKELPFYDCPPGFPGLETALPLLLTLYKRGIISLNKVVRSYSELPAKLLGLWPDL
GRLETGSLASFTVVDVNERRRVEPWEFESKAKYSPFEGMNLWGEVVATVVRGKIRYFSGNFYY
>Mature_383_residues
MVEATLISEGERLAVRGPSAACDCETCLEMRGTIALPGMVDAHVHTRGLMLSHKEDPLTASRAALKGGVVAIADMPNTLP
KINNLEILKKRLEEFKRTCLVDCYQYAGVPESPEELRAMSKHVVGVKVYPEDYPNLHVLRNYDGLIVVHPEHPAFVKESP
DPGERGLSRSPFAEPAAMELFRGFSKVHFTHVSTPEGARKAEEMGFTFDVTPHHILLNNEVEKLKGCVAKVNPPLRDEPR
RGMMFDIFVNKDVMMVTDHAPHAVWEKELPFYDCPPGFPGLETALPLLLTLYKRGIISLNKVVRSYSELPAKLLGLWPDL
GRLETGSLASFTVVDVNERRRVEPWEFESKAKYSPFEGMNLWGEVVATVVRGKIRYFSGNFYY

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=371, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786722, Length=426, Percent_Identity=26.056338028169, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082175, Length=399, Percent_Identity=24.812030075188, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=362, Percent_Identity=29.0055248618785, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24642586, Length=363, Percent_Identity=31.404958677686, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI18859883, Length=404, Percent_Identity=25.4950495049505, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 42947; Mature: 42947

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEATLISEGERLAVRGPSAACDCETCLEMRGTIALPGMVDAHVHTRGLMLSHKEDPLTA
CCCEEEECCCCEEEEECCCCCCCHHHHHHCCCCEECCCCEECCCHHCCEEEECCCCCCHH
SRAALKGGVVAIADMPNTLPKINNLEILKKRLEEFKRTCLVDCYQYAGVPESPEELRAMS
HHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KHVVGVKVYPEDYPNLHVLRNYDGLIVVHPEHPAFVKESPDPGERGLSRSPFAEPAAMEL
HHEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHH
FRGFSKVHFTHVSTPEGARKAEEMGFTFDVTPHHILLNNEVEKLKGCVAKVNPPLRDEPR
HHHHHHEEEEECCCCCHHHHHHHCCCEEECCCCEEEECCCHHHHHHHHHHCCCCCCCCCC
RGMMFDIFVNKDVMMVTDHAPHAVWEKELPFYDCPPGFPGLETALPLLLTLYKRGIISLN
CCCEEEEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVVRSYSELPAKLLGLWPDLGRLETGSLASFTVVDVNERRRVEPWEFESKAKYSPFEGMN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCH
LWGEVVATVVRGKIRYFSGNFYY
HHHHHHHHHHHCCEEEECCCCCC
>Mature Secondary Structure
MVEATLISEGERLAVRGPSAACDCETCLEMRGTIALPGMVDAHVHTRGLMLSHKEDPLTA
CCCEEEECCCCEEEEECCCCCCCHHHHHHCCCCEECCCCEECCCHHCCEEEECCCCCCHH
SRAALKGGVVAIADMPNTLPKINNLEILKKRLEEFKRTCLVDCYQYAGVPESPEELRAMS
HHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KHVVGVKVYPEDYPNLHVLRNYDGLIVVHPEHPAFVKESPDPGERGLSRSPFAEPAAMEL
HHEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHH
FRGFSKVHFTHVSTPEGARKAEEMGFTFDVTPHHILLNNEVEKLKGCVAKVNPPLRDEPR
HHHHHHEEEEECCCCCHHHHHHHCCCEEECCCCEEEECCCHHHHHHHHHHCCCCCCCCCC
RGMMFDIFVNKDVMMVTDHAPHAVWEKELPFYDCPPGFPGLETALPLLLTLYKRGIISLN
CCCEEEEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVVRSYSELPAKLLGLWPDLGRLETGSLASFTVVDVNERRRVEPWEFESKAKYSPFEGMN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCH
LWGEVVATVVRGKIRYFSGNFYY
HHHHHHHHHHHCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]