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The map label for this gene is uppS [H]

Identifier: 156937379

GI number: 156937379

Start: 526541

End: 527353

Strand: Reverse

Name: uppS [H]

Synonym: Igni_0586

Alternate gene names: 156937379

Gene position: 527353-526541 (Counterclockwise)

Preceding gene: 156937380

Following gene: 156937376

Centisome position: 40.64

GC content: 53.38

Gene sequence:

>813_bases
TTGCAAACCAGAGCCGCGCTAGCGAACAGGGGCTGGAGGACAATATCCTTCTTGATGAAGCCAATATACGAGATATATGA
AAAGAAGCTGGAAGCGGAGATAAGCAAGGACCATTTGCCCAAACACGTAGCAATAATTCCCGACGGCAACAGGAGGTGGG
CGCGGATGAGGGGGCTCCAAGAGTGGTTGGGTCATAGAGAAGGCTACAAGAAGATGAGGGAAGTGTTAATGTGGTTGTTG
GAGTTAGGGATAGAGGTGGTCACAGTCTTCGCTATGTCGACGGAGAACTGCACTAGGAGGAGCCCGGAGGAGAGGGAAAA
GCTTTACGAGCTCATAGCCGGGGGCTTGAGGGAGCTCGCCAAGGACGAGATAGTTCACAGAAACGAAGTAAAGGTCATGG
TAATAGGGAGAAGGAACTTGTGGCCCAAGGAACTCCTCGAGGCCGCTAAGGAGGTAGAGGAGGCTACGAAGGGTTACAAC
AAGAGGGTGATAAACGTCGCCGTGTGTTACGGGGGCCGACAAGAAATAGTTGACGCGGTGAGGAAGATAGCTTGGAAGGT
GAAGAGGGGGGAGCTGGAGCCGGACCAGATAGACGAGAACGTGATCACCCAACACTTATACACGGAGAACTTACCCGACC
CCGACTTGATAATAAGGACGAGCGGGGAGGAGAGGATAAGCAACTTCTTGCTCTGGCAGTCGGCGTACAGCGAGCTCTAC
TTCGCCAACATCTACTGGCCAGAAATAAGGAGGATAGACATACTGAGGGCCCTCCGGGACTACCAGAGGAGGCAGAGGAG
GTTCGGGCGCTGA

Upstream 100 bases:

>100_bases
CGCTCCACGAAGTCCAACTGCTTGCCCCCGAAGTCAGGTTCGGGCCTCTCATCCCTACTTAATTTTAATCCCAACTAACC
CGCTGAACGGGAGTTAATGC

Downstream 100 bases:

>100_bases
GCGAGGTCGGCTAGGGGGGCCCTCTCCGCTCACCCCTCGCGACCCGGACCAACTCCTCATCCGTAGAGCCGAAACCCCCC
GACCTGCCGTCGTTTGGGGG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQTRAALANRGWRTISFLMKPIYEIYEKKLEAEISKDHLPKHVAIIPDGNRRWARMRGLQEWLGHREGYKKMREVLMWLL
ELGIEVVTVFAMSTENCTRRSPEEREKLYELIAGGLRELAKDEIVHRNEVKVMVIGRRNLWPKELLEAAKEVEEATKGYN
KRVINVAVCYGGRQEIVDAVRKIAWKVKRGELEPDQIDENVITQHLYTENLPDPDLIIRTSGEERISNFLLWQSAYSELY
FANIYWPEIRRIDILRALRDYQRRQRRFGR

Sequences:

>Translated_270_residues
MQTRAALANRGWRTISFLMKPIYEIYEKKLEAEISKDHLPKHVAIIPDGNRRWARMRGLQEWLGHREGYKKMREVLMWLL
ELGIEVVTVFAMSTENCTRRSPEEREKLYELIAGGLRELAKDEIVHRNEVKVMVIGRRNLWPKELLEAAKEVEEATKGYN
KRVINVAVCYGGRQEIVDAVRKIAWKVKRGELEPDQIDENVITQHLYTENLPDPDLIIRTSGEERISNFLLWQSAYSELY
FANIYWPEIRRIDILRALRDYQRRQRRFGR
>Mature_270_residues
MQTRAALANRGWRTISFLMKPIYEIYEKKLEAEISKDHLPKHVAIIPDGNRRWARMRGLQEWLGHREGYKKMREVLMWLL
ELGIEVVTVFAMSTENCTRRSPEEREKLYELIAGGLRELAKDEIVHRNEVKVMVIGRRNLWPKELLEAAKEVEEATKGYN
KRVINVAVCYGGRQEIVDAVRKIAWKVKRGELEPDQIDENVITQHLYTENLPDPDLIIRTSGEERISNFLLWQSAYSELY
FANIYWPEIRRIDILRALRDYQRRQRRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=41.3333333333333, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=41.3333333333333, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=42.6724137931034, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=33.6206896551724, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=237, Percent_Identity=35.0210970464135, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=28.7037037037037, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=37.9310344827586, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 32037; Mature: 32037

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRAALANRGWRTISFLMKPIYEIYEKKLEAEISKDHLPKHVAIIPDGNRRWARMRGLQ
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
EWLGHREGYKKMREVLMWLLELGIEVVTVFAMSTENCTRRSPEEREKLYELIAGGLRELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHH
KDEIVHRNEVKVMVIGRRNLWPKELLEAAKEVEEATKGYNKRVINVAVCYGGRQEIVDAV
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHH
RKIAWKVKRGELEPDQIDENVITQHLYTENLPDPDLIIRTSGEERISNFLLWQSAYSELY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
FANIYWPEIRRIDILRALRDYQRRQRRFGR
EEEEECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTRAALANRGWRTISFLMKPIYEIYEKKLEAEISKDHLPKHVAIIPDGNRRWARMRGLQ
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
EWLGHREGYKKMREVLMWLLELGIEVVTVFAMSTENCTRRSPEEREKLYELIAGGLRELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHH
KDEIVHRNEVKVMVIGRRNLWPKELLEAAKEVEEATKGYNKRVINVAVCYGGRQEIVDAV
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHH
RKIAWKVKRGELEPDQIDENVITQHLYTENLPDPDLIIRTSGEERISNFLLWQSAYSELY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
FANIYWPEIRRIDILRALRDYQRRQRRFGR
EEEEECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]