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The map label for this gene is hisI

Identifier: 156937355

GI number: 156937355

Start: 505017

End: 505406

Strand: Direct

Name: hisI

Synonym: Igni_0562

Alternate gene names: 156937355

Gene position: 505017-505406 (Clockwise)

Preceding gene: 156937354

Following gene: 156937365

Centisome position: 38.92

GC content: 55.9

Gene sequence:

>390_bases
TTGATGAGGGTTAGCGAAGAGGAGGCGAAGAGGATAGCGGAGAGGCTGAACTACAGGTGGCCCGACCGGACGGTGGTGGC
GGTGGCTCAAGAGTACAAGAGCGGGAAGGTATTGATGGTTGCCTCCATGAACAAAGAGGCGGTAATAAAGACCCTCACCA
CGGGAATAGTCCACTACTGGAGCAAGAGCAGAAAGGAACTGTGGGTGAAGGGGGCCACCAGCGGTCACGTACAAGTCCTA
GAGAAGTTCTACTACGACTGCGACGCCGACTCCGTGTTGCTGGTGGTGAGGCAAGCCTCGCTCATAGCTTGCCACGAGGG
CTACCGCTCGTGCTTTCACTACAAAGTAGAAGAGGGGGGAGTGAAAGTAGAAGAGCCCAGCTACGAGTAG

Upstream 100 bases:

>100_bases
AAGGTCAAAGTTAATGGTGAGACCTACTGGGTTAAGGTGATAGACGGCGACTTCTTGTACATATTCTCCCAACACGACGG
GGAGGTGGAGGTGGAGATAG

Downstream 100 bases:

>100_bases
CCCATCGAATAAACTAACAAGGCTAGGAAGGCCGCCAAGGTCACTGGAGCAACGAACTGCGCTAACTTGCAGTTGTTCTT
AAATAAAATGTAACTCAAAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MMRVSEEEAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGATSGHVQVL
EKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEEGGVKVEEPSYE

Sequences:

>Translated_129_residues
MMRVSEEEAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGATSGHVQVL
EKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEEGGVKVEEPSYE
>Mature_129_residues
MMRVSEEEAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGATSGHVQVL
EKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEEGGVKVEEPSYE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=97, Percent_Identity=39.1752577319588, Blast_Score=74, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_IGNH4 (A8A9Z2)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435151.1
- ProteinModelPortal:   A8A9Z2
- SMR:   A8A9Z2
- STRING:   A8A9Z2
- GeneID:   5561919
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0562
- eggNOG:   arNOG12274
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- BioCyc:   IHOS453591:IGNI_0562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14823; Mature: 14823

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRVSEEEAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYW
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHH
SKSRKELWVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEEGG
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHEEEECCCC
VKVEEPSYE
EEECCCCCC
>Mature Secondary Structure
MMRVSEEEAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYW
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHH
SKSRKELWVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEEGG
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHEEEECCCC
VKVEEPSYE
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA