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The map label for this gene is apr [H]

Identifier: 156937327

GI number: 156937327

Start: 477153

End: 478562

Strand: Direct

Name: apr [H]

Synonym: Igni_0534

Alternate gene names: 156937327

Gene position: 477153-478562 (Clockwise)

Preceding gene: 156937324

Following gene: 156937328

Centisome position: 36.77

GC content: 61.13

Gene sequence:

>1410_bases
TTGCGAGCCTTAATAATATTATTACTCGTCGTCTCGTCAATGCTCGCGGACTCCGGGGACTGCGCCTTCGGGTGGTGGAA
GGACCTCTTGCGGGCCCCTGACGCCCACTCGGAAGGGGTCACCGGAAAGGGCGTGGTGGCCTTAGTTATAGACACCGGAG
TCGACGCCGAGGTAATTAAATCTGTATTCAATAGGACTGTTGACCGGTACTTCAACGCGGCCTACGAGGCTCACAAGGAC
GAGTGCTTTAAGTACGTAGACTACAAGAACGTCACCATGTGCGTGTACGGCTTGACGGAGGTAGGGGGGAGGAGCGCTTA
CTTGGCCGCCCCCGTGAACGAAACCACCGACTTGGCCGGCCACGGGACCGCCGTCGCGGCCGCCCTGCTGTCGGTGGCCC
CCGACGTAGACTTGCACGTTGCTAAGGTGGCTTGCTACGTCCTACTCCTCGACGAGAACGGCTCCGTGACTTACGCAATC
CCATTCATAGACCCAGAAGCCTTGAAGCTCGCATTGGAAAGGGCAGTTAACGGGACGGACGTAGTGAACTTGAGCTTGGG
CTCGGTAACTCCCGTCACCGGCCCCTTGCCGGACGTCCCGACCGCCTTAGCCCTCAGGGGGCTGTGGGACGTTATCTACT
CTAAGAGCTCAGAAACAGCCTTCGTGGCGGCTGCGGGCAACGAGGGCCTCAAGGTCCCCTCCTTCCCCGCGCTCTCGGAG
CACGTCATAGGCGTCTCGGCCTTAGCTTACAAGGACGGCGAGTTTGAGGTGGCGAGCTTCAGCGACGGGGGGCCCGGGGT
AGACTTTTCCAGCGTAGGGGTCGGGCTCTACTTGCCGGTCCCCAAGTACTCTTACATAGCCGAAGCGGTGAAGGACCCGT
GCGCCGAGGAGGTCGGAAGGGCCCTGTTCTTGAGGCTGGACGGAACCTCTTTCGCCGCCCCGCTGGTCTCGGGTACCGCC
GCGCTGTGGATCCAGAGGACGGGGGTCAAAGGGACCTCTGAGGTGAGAGAGGTGTTAAAACAGAACTCATTGCACCCCTT
CGGCCCCGGGTGGTCGCCCGAGGCCGGCTGGGGGGTGCCGGTGGCCGTGCCGGTGGAGGGCCAAGGGCTCTCCTTGCCCG
GAATACCCTTCGCCGGCTTGCCCGCGTTGCTCCTAGCGAAGCGCAAGAGGGGAGCTACGCTCTTGACAATTATGATGATA
AGTTCATCGGCCTTCGCCGTGGAGCCGGAGAAGCTGGGCGAGGCCTTCGCGATCTCTTCCCTAGCCACTTGGACCGCGTA
CTACGTCGCGAACGGCCTCGGCCCGGTCGCCTCGCTCTGGATGGCCACCTTCAACACTTTGATCGTTACTGCCTTGTTAG
CAATATCTTGGAAGGTCGTGGAGCTCGTGTGCGCAACGATTAAGTGTTAG

Upstream 100 bases:

>100_bases
GGGCCTACTACGCCCTCACGAACTTCATCTTGGGGGCCTTCTTCTTGGTGACCTTCTCCATTTCTCTGTTCATTGTGGAG
GAGTTGGGGTGGTGAGGGGT

Downstream 100 bases:

>100_bases
CCCGGAGGCCCCAGAGGCGGGCAAGCTAGGTTGAAGGCCCTAAAGAAGCTGGCAGAAAAGCTCGAGGACCCGAGATCGGT
GGCGAAGGCCACATTCGCCA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRALIILLLVVSSMLADSGDCAFGWWKDLLRAPDAHSEGVTGKGVVALVIDTGVDAEVIKSVFNRTVDRYFNAAYEAHKD
ECFKYVDYKNVTMCVYGLTEVGGRSAYLAAPVNETTDLAGHGTAVAAALLSVAPDVDLHVAKVACYVLLLDENGSVTYAI
PFIDPEALKLALERAVNGTDVVNLSLGSVTPVTGPLPDVPTALALRGLWDVIYSKSSETAFVAAAGNEGLKVPSFPALSE
HVIGVSALAYKDGEFEVASFSDGGPGVDFSSVGVGLYLPVPKYSYIAEAVKDPCAEEVGRALFLRLDGTSFAAPLVSGTA
ALWIQRTGVKGTSEVREVLKQNSLHPFGPGWSPEAGWGVPVAVPVEGQGLSLPGIPFAGLPALLLAKRKRGATLLTIMMI
SSSAFAVEPEKLGEAFAISSLATWTAYYVANGLGPVASLWMATFNTLIVTALLAISWKVVELVCATIKC

Sequences:

>Translated_469_residues
MRALIILLLVVSSMLADSGDCAFGWWKDLLRAPDAHSEGVTGKGVVALVIDTGVDAEVIKSVFNRTVDRYFNAAYEAHKD
ECFKYVDYKNVTMCVYGLTEVGGRSAYLAAPVNETTDLAGHGTAVAAALLSVAPDVDLHVAKVACYVLLLDENGSVTYAI
PFIDPEALKLALERAVNGTDVVNLSLGSVTPVTGPLPDVPTALALRGLWDVIYSKSSETAFVAAAGNEGLKVPSFPALSE
HVIGVSALAYKDGEFEVASFSDGGPGVDFSSVGVGLYLPVPKYSYIAEAVKDPCAEEVGRALFLRLDGTSFAAPLVSGTA
ALWIQRTGVKGTSEVREVLKQNSLHPFGPGWSPEAGWGVPVAVPVEGQGLSLPGIPFAGLPALLLAKRKRGATLLTIMMI
SSSAFAVEPEKLGEAFAISSLATWTAYYVANGLGPVASLWMATFNTLIVTALLAISWKVVELVCATIKC
>Mature_469_residues
MRALIILLLVVSSMLADSGDCAFGWWKDLLRAPDAHSEGVTGKGVVALVIDTGVDAEVIKSVFNRTVDRYFNAAYEAHKD
ECFKYVDYKNVTMCVYGLTEVGGRSAYLAAPVNETTDLAGHGTAVAAALLSVAPDVDLHVAKVACYVLLLDENGSVTYAI
PFIDPEALKLALERAVNGTDVVNLSLGSVTPVTGPLPDVPTALALRGLWDVIYSKSSETAFVAAAGNEGLKVPSFPALSE
HVIGVSALAYKDGEFEVASFSDGGPGVDFSSVGVGLYLPVPKYSYIAEAVKDPCAEEVGRALFLRLDGTSFAAPLVSGTA
ALWIQRTGVKGTSEVREVLKQNSLHPFGPGWSPEAGWGVPVAVPVEGQGLSLPGIPFAGLPALLLAKRKRGATLLTIMMI
SSSAFAVEPEKLGEAFAISSLATWTAYYVANGLGPVASLWMATFNTLIVTALLAISWKVVELVCATIKC

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 49302; Mature: 49302

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALIILLLVVSSMLADSGDCAFGWWKDLLRAPDAHSEGVTGKGVVALVIDTGVDAEVIK
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
SVFNRTVDRYFNAAYEAHKDECFKYVDYKNVTMCVYGLTEVGGRSAYLAAPVNETTDLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCEEEEECCCCCCCCCC
HGTAVAAALLSVAPDVDLHVAKVACYVLLLDENGSVTYAIPFIDPEALKLALERAVNGTD
CHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCC
VVNLSLGSVTPVTGPLPDVPTALALRGLWDVIYSKSSETAFVAAAGNEGLKVPSFPALSE
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHH
HVIGVSALAYKDGEFEVASFSDGGPGVDFSSVGVGLYLPVPKYSYIAEAVKDPCAEEVGR
HHHEEEEEEEECCCEEEEEECCCCCCCCHHHCCEEEEECCCCHHHHHHHHHCHHHHHHCC
ALFLRLDGTSFAAPLVSGTAALWIQRTGVKGTSEVREVLKQNSLHPFGPGWSPEAGWGVP
EEEEEECCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VAVPVEGQGLSLPGIPFAGLPALLLAKRKRGATLLTIMMISSSAFAVEPEKLGEAFAISS
EEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHCHHHHHHH
LATWTAYYVANGLGPVASLWMATFNTLIVTALLAISWKVVELVCATIKC
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALIILLLVVSSMLADSGDCAFGWWKDLLRAPDAHSEGVTGKGVVALVIDTGVDAEVIK
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
SVFNRTVDRYFNAAYEAHKDECFKYVDYKNVTMCVYGLTEVGGRSAYLAAPVNETTDLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCEEEEECCCCCCCCCC
HGTAVAAALLSVAPDVDLHVAKVACYVLLLDENGSVTYAIPFIDPEALKLALERAVNGTD
CHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCC
VVNLSLGSVTPVTGPLPDVPTALALRGLWDVIYSKSSETAFVAAAGNEGLKVPSFPALSE
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHH
HVIGVSALAYKDGEFEVASFSDGGPGVDFSSVGVGLYLPVPKYSYIAEAVKDPCAEEVGR
HHHEEEEEEEECCCEEEEEECCCCCCCCHHHCCEEEEECCCCHHHHHHHHHCHHHHHHCC
ALFLRLDGTSFAAPLVSGTAALWIQRTGVKGTSEVREVLKQNSLHPFGPGWSPEAGWGVP
EEEEEECCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VAVPVEGQGLSLPGIPFAGLPALLLAKRKRGATLLTIMMISSSAFAVEPEKLGEAFAISS
EEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHCHHHHHHH
LATWTAYYVANGLGPVASLWMATFNTLIVTALLAISWKVVELVCATIKC
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]