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The map label for this gene is 156937312

Identifier: 156937312

GI number: 156937312

Start: 463976

End: 465031

Strand: Direct

Name: 156937312

Synonym: Igni_0519

Alternate gene names: NA

Gene position: 463976-465031 (Clockwise)

Preceding gene: 156937311

Following gene: 156937317

Centisome position: 35.76

GC content: 58.9

Gene sequence:

>1056_bases
TTGGAGGTCTTAAAGCCGGTCGACCTAGTGGGCGATAAGGTAGTGTGGCTGGACACGAGGTACATACCTTGGAAGGAGGT
CTGGAAGGAGACTACCGATTACAAGGAGGTGGCCAGGGCCATAAAGGACATGGAGGTTAGGGGGGCCCCGGCGATAGGGG
TAGCGGCTGCCTTCGGGATGGCGCTGGCGGCCTTGCACTACGAAGGGGAGGACGTGGAGGGCCTGTTGAGGCGTTTGAGG
GAGGCTAAGGAAGTCCTCGCGAACACCAGGCCGACCGCGGTGAACTTGTTCTGGGCCCTAGAAAGGGTCATGAAGAGGGC
CGAAGAGGCCACGAGGTCCGGCTCGGCGGAGGCGGTGAGAGAGGCCGTGGTCGAGGAGGCCAGAAAGATCCAACAAGAGG
ACATAGAGTCCAACGTGAAGATGGGCAAGATCGGGGCCAAGCTGATAGAGGACGGGGACGTGGTGCTGACCCACTGCAAC
ACCGGGAGTTTAGCGACCGCGGGCTACGGGACCGCCTTGGGCGTGATAAGGGCCGCGTGGGAGGAGGGGAAGAGGATAGA
AGTGATAGCCACCGAAACCAGGCCGCTGGACCAAGGGGCGAGGCTGACGGTGTGGGAGCTCAAGAGGGACGGAATCCCAG
TGAAGCTCATAGCAGACACTATGGTAGGATACTTAATGAGCAAAGGTAAGGTAGACAAAGTGTTCTTGGGGGCCGACAGG
ATACTCCTCAGCGGCCACTTCGCCAACAAGATAGGCACGTACCAAATAGCGGTCTTGGCCAAACACCACGGGGTCCCCTT
CTACGTGGTGGCCCCGACGTCCACAGTGGACCCCAAGATAACCTTAGACGAGCTCGTCATAGAAGAGAGGGACCCAGACG
AAGTTAGGCGCTGCCCCTACCCCTTCGAGAAGGTGTACGTAACCGTGAGGGACGTAGAGGTTTACAACCCGGCCTTCGAC
GTCACCCCGCCGGAGCTGGTAACTGCCATAATAACGGAAAGGGGGATCGCTTACCCGCCGTTCTACGTGAGCTTGAAAAA
GCTATTGGAAGGCTAA

Upstream 100 bases:

>100_bases
TCGTGGAGCTCTTGCACTCCGCGGCGGAGAGGGGCTGTGACCCCTCCCGCGCCCTAGGCCTCTTGATTAAGCTCTTCGAA
GGGGGAGTGGGGGAAGGGCC

Downstream 100 bases:

>100_bases
CCGCACCTCTCGCCGACGACCGTAAGCTCGAAGGTTTTCTCGTGAACCATACCGTTCAGCGTGTAGGCCACCCTCACTAC
CGCTTGGTGGGCCCCGGGGG

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MEVLKPVDLVGDKVVWLDTRYIPWKEVWKETTDYKEVARAIKDMEVRGAPAIGVAAAFGMALAALHYEGEDVEGLLRRLR
EAKEVLANTRPTAVNLFWALERVMKRAEEATRSGSAEAVREAVVEEARKIQQEDIESNVKMGKIGAKLIEDGDVVLTHCN
TGSLATAGYGTALGVIRAAWEEGKRIEVIATETRPLDQGARLTVWELKRDGIPVKLIADTMVGYLMSKGKVDKVFLGADR
ILLSGHFANKIGTYQIAVLAKHHGVPFYVVAPTSTVDPKITLDELVIEERDPDEVRRCPYPFEKVYVTVRDVEVYNPAFD
VTPPELVTAIITERGIAYPPFYVSLKKLLEG

Sequences:

>Translated_351_residues
MEVLKPVDLVGDKVVWLDTRYIPWKEVWKETTDYKEVARAIKDMEVRGAPAIGVAAAFGMALAALHYEGEDVEGLLRRLR
EAKEVLANTRPTAVNLFWALERVMKRAEEATRSGSAEAVREAVVEEARKIQQEDIESNVKMGKIGAKLIEDGDVVLTHCN
TGSLATAGYGTALGVIRAAWEEGKRIEVIATETRPLDQGARLTVWELKRDGIPVKLIADTMVGYLMSKGKVDKVFLGADR
ILLSGHFANKIGTYQIAVLAKHHGVPFYVVAPTSTVDPKITLDELVIEERDPDEVRRCPYPFEKVYVTVRDVEVYNPAFD
VTPPELVTAIITERGIAYPPFYVSLKKLLEG
>Mature_351_residues
MEVLKPVDLVGDKVVWLDTRYIPWKEVWKETTDYKEVARAIKDMEVRGAPAIGVAAAFGMALAALHYEGEDVEGLLRRLR
EAKEVLANTRPTAVNLFWALERVMKRAEEATRSGSAEAVREAVVEEARKIQQEDIESNVKMGKIGAKLIEDGDVVLTHCN
TGSLATAGYGTALGVIRAAWEEGKRIEVIATETRPLDQGARLTVWELKRDGIPVKLIADTMVGYLMSKGKVDKVFLGADR
ILLSGHFANKIGTYQIAVLAKHHGVPFYVVAPTSTVDPKITLDELVIEERDPDEVRRCPYPFEKVYVTVRDVEVYNPAFD
VTPPELVTAIITERGIAYPPFYVSLKKLLEG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=335, Percent_Identity=42.3880597014925, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI23943880, Length=327, Percent_Identity=35.1681957186544, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI78000158, Length=269, Percent_Identity=28.2527881040892, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI78000156, Length=269, Percent_Identity=28.2527881040892, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI187607323, Length=269, Percent_Identity=28.2527881040892, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4503503, Length=280, Percent_Identity=29.2857142857143, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI7657058, Length=192, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557462, Length=335, Percent_Identity=36.7164179104478, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17557123, Length=278, Percent_Identity=28.0575539568345, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325375, Length=379, Percent_Identity=34.5646437994723, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322878, Length=271, Percent_Identity=29.520295202952, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357667, Length=352, Percent_Identity=39.4886363636364, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24651647, Length=352, Percent_Identity=39.4886363636364, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI281364091, Length=194, Percent_Identity=31.9587628865979, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24659399, Length=194, Percent_Identity=31.9587628865979, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24659407, Length=194, Percent_Identity=31.9587628865979, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922816, Length=194, Percent_Identity=31.9587628865979, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18543295, Length=228, Percent_Identity=25.8771929824561, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358605, Length=263, Percent_Identity=25.4752851711027, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38989; Mature: 38989

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLKPVDLVGDKVVWLDTRYIPWKEVWKETTDYKEVARAIKDMEVRGAPAIGVAAAFGM
CCCCCCHHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
ALAALHYEGEDVEGLLRRLREAKEVLANTRPTAVNLFWALERVMKRAEEATRSGSAEAVR
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EAVVEEARKIQQEDIESNVKMGKIGAKLIEDGDVVLTHCNTGSLATAGYGTALGVIRAAW
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCEECCCCHHHHHHHHHHH
EEGKRIEVIATETRPLDQGARLTVWELKRDGIPVKLIADTMVGYLMSKGKVDKVFLGADR
HCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCEEEECCCE
ILLSGHFANKIGTYQIAVLAKHHGVPFYVVAPTSTVDPKITLDELVIEERDPDEVRRCPY
EEEECCHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCEEHHHHHHCCCCHHHHHHCCC
PFEKVYVTVRDVEVYNPAFDVTPPELVTAIITERGIAYPPFYVSLKKLLEG
CHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MEVLKPVDLVGDKVVWLDTRYIPWKEVWKETTDYKEVARAIKDMEVRGAPAIGVAAAFGM
CCCCCCHHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
ALAALHYEGEDVEGLLRRLREAKEVLANTRPTAVNLFWALERVMKRAEEATRSGSAEAVR
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EAVVEEARKIQQEDIESNVKMGKIGAKLIEDGDVVLTHCNTGSLATAGYGTALGVIRAAW
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCCEECCCCHHHHHHHHHHH
EEGKRIEVIATETRPLDQGARLTVWELKRDGIPVKLIADTMVGYLMSKGKVDKVFLGADR
HCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCEEEECCCE
ILLSGHFANKIGTYQIAVLAKHHGVPFYVVAPTSTVDPKITLDELVIEERDPDEVRRCPY
EEEECCHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCEEHHHHHHCCCCHHHHHHCCC
PFEKVYVTVRDVEVYNPAFDVTPPELVTAIITERGIAYPPFYVSLKKLLEG
CHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]