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The map label for this gene is hemA

Identifier: 156937306

GI number: 156937306

Start: 451641

End: 452966

Strand: Direct

Name: hemA

Synonym: Igni_0512

Alternate gene names: 156937306

Gene position: 451641-452966 (Clockwise)

Preceding gene: 156937305

Following gene: 156937309

Centisome position: 34.81

GC content: 55.43

Gene sequence:

>1326_bases
GTGCCCGCCGCCGCCAGAGTGCCCCTCTTCGTTGACGATTTGGTGATGGTAGGGGTAAACTACAAGACGTCCGGGAAGGA
GCTGGTCGAGAAGGCCCAGTTCCCCGACCCTCTGGCGGCCTACTCGGCGATCAGCAGGATACCGGCAGTGAGGGAAGTGG
TCCTACTCCAGACTTGCAATAGGGTAGAAGTTTACGCAATAACGACTAACAAAAAGGCCACTGTAGAGTCCATCAAGAGC
TTGTTGGAAGCTAGGGCGGGGGAGCCCATACCGGAGGAAAAGTTCGTCATTTACTACGGCACGGACGCCGTGAGGCACTT
GTTCCGCGTGGCAGCTGGTTTGGAATCCATGGTGCTCGGAGAGCCGGACATATTGAGGCAAGTTAGGGAGGCGGCGGAGT
TCGCTGCCAAAGAGGGGTACATAGGTAAAGCGTTGAAGCTGACGTTCGAGAACGCAGTAAGAGTGGGGAAGAGGGTGAGG
ACGGAGACTGCGCTGGGGAAGGGCAGCATAGGCATCCCCTCTGCCTCGGTCAAGCTCTTGGAGGAGCTGATAGGGCTCGA
GGGGAAGAAGCTGCTCGTGGTGGGCGCCGGGATGGCCGGGAGGGTGGTGGCAGTCAACGCAGCGAAGAGGGGAGCCAAAG
TGATAATCGTTAACAGAACTTTAAGCAAGGCGAAAGAGCTGGCCGAGGAGGTCGGCGGGGAGGCCTACCCCTTGGAGGAG
CTCCCCCGGCTCCTAAGGGAGGCGGACGCGGTGGTGGTCGCCGTGGGAGGGGGGAGCAAGGTAATAACTAGGGACGCGGT
GGCAGAAGTAAACAAGAAGCTGGTGATAGTGGACATTTCCGAACCTCCGGCCGTAGACCCTGGAGTTTCCTTAAACCCCT
ACGTGATATACAAAGACATGTTAGCGGTGGCGGAAGTGGCGAACAGGGGACTGGAGAAGAGGAAGTCAGAAATAAAGAGG
GCCGAAGACATAATAGAGGCGGAGCTGAACAAGTTCGTTAACTTCGCCCAGAGGGTGTTAGCGGACAAGATCTTAAGGGA
GTTGATGGAGAAGGTAGAACAGATTAGAATAAACGAGCTCTCCAAGGCGATGGCCAAAGTACCCCAAGAGTACGCAGAGG
TGTTGGACAAGATGACGTCGTCCCTAGTCAAGAAGGTTCTAAAGGACGTCATCTTGAAGGTGAGGGAAGCTGCCGGGAAG
GGGGACCTAACCACCTTGAGGATAGTGGCGGAAGTCTTCGACTTGAAAGAGTCCTTGAACAACATAGAAATAATATACGA
TTACAACGGCGTGGAACAAGAGCTCAAACGGAAGCTCGAGCTTTAA

Upstream 100 bases:

>100_bases
AGGAGGGGTGGTTTAAGTTTCGCTTCCGAGACATGAGGTCTATCTATTTTACAGAAAACCCTATTAATTAGGTCACGGGG
CTTCAGACGGCGATCAATCA

Downstream 100 bases:

>100_bases
CCTCCGCCTCCGTCGCCCCGCGGGCACGCCCTTTGTGGAGGGTCGCGGTAGACGTAGGCGGCACGTTCACGGACCTCTTC
GCCGTGGGTCCCAGAGGTTA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCNRVEVYAITTNKKATVESIKS
LLEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLGEPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVR
TETALGKGSIGIPSASVKLLEELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEE
LPRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDMLAVAEVANRGLEKRKSEIKR
AEDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINELSKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGK
GDLTTLRIVAEVFDLKESLNNIEIIYDYNGVEQELKRKLEL

Sequences:

>Translated_441_residues
MPAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCNRVEVYAITTNKKATVESIKS
LLEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLGEPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVR
TETALGKGSIGIPSASVKLLEELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEE
LPRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDMLAVAEVANRGLEKRKSEIKR
AEDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINELSKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGK
GDLTTLRIVAEVFDLKESLNNIEIIYDYNGVEQELKRKLEL
>Mature_440_residues
PAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCNRVEVYAITTNKKATVESIKSL
LEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLGEPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVRT
ETALGKGSIGIPSASVKLLEELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEEL
PRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDMLAVAEVANRGLEKRKSEIKRA
EDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINELSKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGKG
DLTTLRIVAEVFDLKESLNNIEIIYDYNGVEQELKRKLEL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=30.622009569378, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_IGNH4 (A8A9U3)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435102.1
- ProteinModelPortal:   A8A9U3
- SMR:   A8A9U3
- STRING:   A8A9U3
- GeneID:   5562776
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0512
- eggNOG:   arNOG04783
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- BioCyc:   IHOS453591:IGNI_0512-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48267; Mature: 48136

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 59-59 BINDING 116-116 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCN
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RVEVYAITTNKKATVESIKSLLEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLG
CEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCC
EPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVRTETALGKGSIGIPSASVKLL
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
EELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEE
HHHHCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHHHHCCCCCCHHH
LPRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDM
HHHHHHHCCEEEEEECCCCCEEHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LAVAEVANRGLEKRKSEIKRAEDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINEL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGKGDLTTLRIVAEVFDLKESLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
NIEIIYDYNGVEQELKRKLEL
CEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure 
PAAARVPLFVDDLVMVGVNYKTSGKELVEKAQFPDPLAAYSAISRIPAVREVVLLQTCN
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RVEVYAITTNKKATVESIKSLLEARAGEPIPEEKFVIYYGTDAVRHLFRVAAGLESMVLG
CEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCC
EPDILRQVREAAEFAAKEGYIGKALKLTFENAVRVGKRVRTETALGKGSIGIPSASVKLL
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
EELIGLEGKKLLVVGAGMAGRVVAVNAAKRGAKVIIVNRTLSKAKELAEEVGGEAYPLEE
HHHHCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHHHHCCCCCCHHH
LPRLLREADAVVVAVGGGSKVITRDAVAEVNKKLVIVDISEPPAVDPGVSLNPYVIYKDM
HHHHHHHCCEEEEEECCCCCEEHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LAVAEVANRGLEKRKSEIKRAEDIIEAELNKFVNFAQRVLADKILRELMEKVEQIRINEL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAMAKVPQEYAEVLDKMTSSLVKKVLKDVILKVREAAGKGDLTTLRIVAEVFDLKESLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
NIEIIYDYNGVEQELKRKLEL
CEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA