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The map label for this gene is eif2g [H]

Identifier: 156937117

GI number: 156937117

Start: 279553

End: 280800

Strand: Direct

Name: eif2g [H]

Synonym: Igni_0323

Alternate gene names: 156937117

Gene position: 279553-280800 (Clockwise)

Preceding gene: 156937115

Following gene: 156937119

Centisome position: 21.54

GC content: 61.46

Gene sequence:

>1248_bases
GTGGAAGAGAGGGAAGTGCAGCCCGAGGTTAACATCGGCGTGGTAGGGCACGTGGACCACGGAAAGACCACGTTGGTCCA
AGCGCTCACTGGCGTGTGGACCGCCAGGCACAGCGAGGAGCTCAAGAGGGGGATGACTATAAAGCTGGGCTACGCCGACG
GGGACATATACAAGTGCACCAACTGCCCCGAACCGGACGCCTACTCCCCCGAGCCTAAATGCCCGAGGTGCCCCAAGGGG
AGCGAGCCGGTCCTCCAGAGGAGGGTCTCCTACGTGGACGCCCCGGGACACGAGGTGTTGATGGCCACCATGCTCTCCGG
CTCCTCCTTGGTGGATGGCGCCTTGCTAGTAATAGCTGCAAACGAGCCTTGTCCCCAGCCGCAGACTAAGGAGCACTTCA
TGGCTTTGGACATAATAGGCATTAGGAAGTTAGTTGTCGTCCAGAACAAGATAGACGTGGTGAGCAAGGACCAAGCGATG
AAGAACTACCAACAGATCAGGAAGTTCTTGGAGGGCACTTGGGCTGAGGACGCGGTGGTTGTGCCGGTCAGCGCCTTGCA
CAAGGCCAACATAGACGCGCTGCTGGAGGCGATCCAAGAGGAGATCCCCACTCCCCCGAGGGACTTGGACTCCCCGCCCC
TCATGTGGATAGCTAGGAGCTTCGACGTGAACAGGCCGGGCACGCCCCCGGAGAAGCTCGTAGGAGGGGTCGTCGGGGGC
TCCTTGATGAGGGGGAAGCTGAGGGTAGGGGATAAGATAGAGATAAGGCCCGGCTACGCCGTAAGGAGCGGGAACAAGGT
CGAGTACGTCCCGCTGGAGAGCGAAGTGGTCAGCTTGAGGTTCGGCAACGTGGAGGTAGAAGAGGCCAAGCCCGGCGGGC
TGGTGGCGGTGGGCACCCGGCTGGACCCCTCCGTTACCAAGGCTGACGCCCTCGTGGGGAGCGTGTTGGGGAGGCCCGGG
GAGCTGCCGCCGGTTTACGACCAGCTCACCTTGGAGTACCACTTGCTCGACCGCGTGGTGGGCTTCAGAGGGGGCGAGAT
GAAGATGGCCCCGCTGAGGAGGGGAGAGGTGTTAATGATGACCATAGGTACGAACATAACCATCGGTATGGTAGTCGACT
TGAAGAAGGACGAAATGACCGTGAAGCTCCAGAGGCCCGCGGTGGCCTGGAAGGGGGCGAGGGTGGCCTTCAGCAGGAGG
ATACAAGGCCGCTGGAGGCTGGCGGGCTGGGGCGTGGTTAAAAACTAG

Upstream 100 bases:

>100_bases
GGCGATGAGGTGGGTAACCCCGTCCGAAAGGTGAGGTAGGAATTTTCGTCTGAGCCGACCTTCTTAAGGCCTCTCCCGGA
AGGCCCACGGGGTTATAGGA

Downstream 100 bases:

>100_bases
AACATCTTTAGGTCCAACCCTTCCTTGAGCCACCTCGAGGCCTCCAAGGCGTGGTACGTTATTATTATGTTTGCGCCGGC
CCTCTTTATTGAGTGCAGTA

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MEEREVQPEVNIGVVGHVDHGKTTLVQALTGVWTARHSEELKRGMTIKLGYADGDIYKCTNCPEPDAYSPEPKCPRCPKG
SEPVLQRRVSYVDAPGHEVLMATMLSGSSLVDGALLVIAANEPCPQPQTKEHFMALDIIGIRKLVVVQNKIDVVSKDQAM
KNYQQIRKFLEGTWAEDAVVVPVSALHKANIDALLEAIQEEIPTPPRDLDSPPLMWIARSFDVNRPGTPPEKLVGGVVGG
SLMRGKLRVGDKIEIRPGYAVRSGNKVEYVPLESEVVSLRFGNVEVEEAKPGGLVAVGTRLDPSVTKADALVGSVLGRPG
ELPPVYDQLTLEYHLLDRVVGFRGGEMKMAPLRRGEVLMMTIGTNITIGMVVDLKKDEMTVKLQRPAVAWKGARVAFSRR
IQGRWRLAGWGVVKN

Sequences:

>Translated_415_residues
MEEREVQPEVNIGVVGHVDHGKTTLVQALTGVWTARHSEELKRGMTIKLGYADGDIYKCTNCPEPDAYSPEPKCPRCPKG
SEPVLQRRVSYVDAPGHEVLMATMLSGSSLVDGALLVIAANEPCPQPQTKEHFMALDIIGIRKLVVVQNKIDVVSKDQAM
KNYQQIRKFLEGTWAEDAVVVPVSALHKANIDALLEAIQEEIPTPPRDLDSPPLMWIARSFDVNRPGTPPEKLVGGVVGG
SLMRGKLRVGDKIEIRPGYAVRSGNKVEYVPLESEVVSLRFGNVEVEEAKPGGLVAVGTRLDPSVTKADALVGSVLGRPG
ELPPVYDQLTLEYHLLDRVVGFRGGEMKMAPLRRGEVLMMTIGTNITIGMVVDLKKDEMTVKLQRPAVAWKGARVAFSRR
IQGRWRLAGWGVVKN
>Mature_415_residues
MEEREVQPEVNIGVVGHVDHGKTTLVQALTGVWTARHSEELKRGMTIKLGYADGDIYKCTNCPEPDAYSPEPKCPRCPKG
SEPVLQRRVSYVDAPGHEVLMATMLSGSSLVDGALLVIAANEPCPQPQTKEHFMALDIIGIRKLVVVQNKIDVVSKDQAM
KNYQQIRKFLEGTWAEDAVVVPVSALHKANIDALLEAIQEEIPTPPRDLDSPPLMWIARSFDVNRPGTPPEKLVGGVVGG
SLMRGKLRVGDKIEIRPGYAVRSGNKVEYVPLESEVVSLRFGNVEVEEAKPGGLVAVGTRLDPSVTKADALVGSVLGRPG
ELPPVYDQLTLEYHLLDRVVGFRGGEMKMAPLRRGEVLMMTIGTNITIGMVVDLKKDEMTVKLQRPAVAWKGARVAFSRR
IQGRWRLAGWGVVKN

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=423, Percent_Identity=45.1536643026005, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34147630, Length=350, Percent_Identity=28.8571428571429, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI54607086, Length=296, Percent_Identity=29.0540540540541, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI46094014, Length=334, Percent_Identity=24.8502994011976, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367247, Length=244, Percent_Identity=33.6065573770492, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790412, Length=440, Percent_Identity=26.8181818181818, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789737, Length=440, Percent_Identity=26.8181818181818, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17509919, Length=422, Percent_Identity=44.0758293838863, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17556456, Length=353, Percent_Identity=27.7620396600567, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25141371, Length=363, Percent_Identity=29.2011019283747, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17506081, Length=259, Percent_Identity=25.4826254826255, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320863, Length=423, Percent_Identity=45.3900709219858, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324761, Length=330, Percent_Identity=30.6060606060606, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647046, Length=421, Percent_Identity=45.3681710213777, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24647048, Length=421, Percent_Identity=45.3681710213777, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363316, Length=350, Percent_Identity=31.7142857142857, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17864358, Length=350, Percent_Identity=31.7142857142857, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922690, Length=329, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921738, Length=253, Percent_Identity=32.4110671936759, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137380, Length=332, Percent_Identity=25.9036144578313, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 45469; Mature: 45469

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEREVQPEVNIGVVGHVDHGKTTLVQALTGVWTARHSEELKRGMTIKLGYADGDIYKCT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCEEECC
NCPEPDAYSPEPKCPRCPKGSEPVLQRRVSYVDAPGHEVLMATMLSGSSLVDGALLVIAA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCEEEEEEC
NEPCPQPQTKEHFMALDIIGIRKLVVVQNKIDVVSKDQAMKNYQQIRKFLEGTWAEDAVV
CCCCCCCCCHHHEEEEEHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
VPVSALHKANIDALLEAIQEEIPTPPRDLDSPPLMWIARSFDVNRPGTPPEKLVGGVVGG
EEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCC
SLMRGKLRVGDKIEIRPGYAVRSGNKVEYVPLESEVVSLRFGNVEVEEAKPGGLVAVGTR
HHEECEECCCCEEEECCCEEEECCCEEEEEECCCEEEEEEECCEEEECCCCCCEEEECCC
LDPSVTKADALVGSVLGRPGELPPVYDQLTLEYHLLDRVVGFRGGEMKMAPLRRGEVLMM
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEE
TIGTNITIGMVVDLKKDEMTVKLQRPAVAWKGARVAFSRRIQGRWRLAGWGVVKN
EECCCEEEEEEEEECCCCEEEEEECCCEEECCCHHEEHHHCCCEEEEEECCCCCC
>Mature Secondary Structure
MEEREVQPEVNIGVVGHVDHGKTTLVQALTGVWTARHSEELKRGMTIKLGYADGDIYKCT
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCEEECC
NCPEPDAYSPEPKCPRCPKGSEPVLQRRVSYVDAPGHEVLMATMLSGSSLVDGALLVIAA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCEEEEEEC
NEPCPQPQTKEHFMALDIIGIRKLVVVQNKIDVVSKDQAMKNYQQIRKFLEGTWAEDAVV
CCCCCCCCCHHHEEEEEHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
VPVSALHKANIDALLEAIQEEIPTPPRDLDSPPLMWIARSFDVNRPGTPPEKLVGGVVGG
EEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCC
SLMRGKLRVGDKIEIRPGYAVRSGNKVEYVPLESEVVSLRFGNVEVEEAKPGGLVAVGTR
HHEECEECCCCEEEECCCEEEECCCEEEEEECCCEEEEEEECCEEEECCCCCCEEEECCC
LDPSVTKADALVGSVLGRPGELPPVYDQLTLEYHLLDRVVGFRGGEMKMAPLRRGEVLMM
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEE
TIGTNITIGMVVDLKKDEMTVKLQRPAVAWKGARVAFSRRIQGRWRLAGWGVVKN
EECCCEEEEEEEEECCCCEEEEEECCCEEECCCHHEEHHHCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]