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The map label for this gene is hpsA [H]

Identifier: 156937064

GI number: 156937064

Start: 232430

End: 233077

Strand: Direct

Name: hpsA [H]

Synonym: Igni_0269

Alternate gene names: 156937064

Gene position: 232430-233077 (Clockwise)

Preceding gene: 156937059

Following gene: 156937070

Centisome position: 17.91

GC content: 62.35

Gene sequence:

>648_bases
TTGGTCTGGGAGAGGAGGGAGAGGCCGCTCTTACAAGTAGCCTTGGACTTCACGACCATACCGAGTGCGATCTCCGTCGC
GGTCAAGGCGCTGAAGGCCGACATATTGGAGGTCGGGACCCCGTTGATAAAGTCTGAGGGTTCTAAGGCCGTTTCCGCGA
TAGCCGCGCTCGGCAAGCCTACGCTGGCCGACACCAAGACTTGCGACACCGGGGCCTTGGAGGCCTCCATAGCCTTCGAC
GCGGGGGCCGACGCGATGACCGTCATGGCGTTCTCCGACGACTCCGTCATAAAGGAGGCCGTGGAGGAGGCGGAGAGGAG
GGGGAAGGTGGTGGTGGCCGACATGATGCACTTGAAAGACCCGGTGGAGAGGGCTAAGAGGCTGAAGGAGCTCGGAGTTA
GGGCGGTTGAGCTACACGTAGGGATATCCCAACAGAGGGCCTACGGCGTCACTGCGGCCGACTTGGCGGCGCTGGCGGAG
AGGGTTAGGTCGCTCGGGCTAGTGGTTGCGGTGGCCGGGGGCATAACCCCGGAGACCGCGAGGGCCTTCGTAGGGAAGGC
GGACGTGGTGGTGGTTGGGGGTTATATAACGAAGTCCCCGAATCCAGAAAAGGCCGTTGAGGAGCTCCTTAAGGCTTTGG
GGAGGTAG

Upstream 100 bases:

>100_bases
GCCTCCTTAGGCCCCAGCGCGAACACTTCGACCCTCTCCCGCGTTCTGCCCGACGGAGACGTTAAGGGTTGGGGCGGACC
CCTACGCGCCGGGAAAGGCC

Downstream 100 bases:

>100_bases
GCCCTTACTTTTCGAAGATCGTGTAGCCGCACTTGCCGCAGTGCCACCTGGGCACGGGCTTCAAGTGGTGTGCCATGAAG
CTGCCGCAGCGCGGACACCT

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MVWERRERPLLQVALDFTTIPSAISVAVKALKADILEVGTPLIKSEGSKAVSAIAALGKPTLADTKTCDTGALEASIAFD
AGADAMTVMAFSDDSVIKEAVEEAERRGKVVVADMMHLKDPVERAKRLKELGVRAVELHVGISQQRAYGVTAADLAALAE
RVRSLGLVVAVAGGITPETARAFVGKADVVVVGGYITKSPNPEKAVEELLKALGR

Sequences:

>Translated_215_residues
MVWERRERPLLQVALDFTTIPSAISVAVKALKADILEVGTPLIKSEGSKAVSAIAALGKPTLADTKTCDTGALEASIAFD
AGADAMTVMAFSDDSVIKEAVEEAERRGKVVVADMMHLKDPVERAKRLKELGVRAVELHVGISQQRAYGVTAADLAALAE
RVRSLGLVVAVAGGITPETARAFVGKADVVVVGGYITKSPNPEKAVEELLKALGR
>Mature_215_residues
MVWERRERPLLQVALDFTTIPSAISVAVKALKADILEVGTPLIKSEGSKAVSAIAALGKPTLADTKTCDTGALEASIAFD
AGADAMTVMAFSDDSVIKEAVEEAERRGKVVVADMMHLKDPVERAKRLKELGVRAVELHVGISQQRAYGVTAADLAALAE
RVRSLGLVVAVAGGITPETARAFVGKADVVVVGGYITKSPNPEKAVEELLKALGR

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=212, Percent_Identity=33.0188679245283, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790006, Length=176, Percent_Identity=32.3863636363636, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR017120
- InterPro:   IPR001754
- InterPro:   IPR011060
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6; PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 22600; Mature: 22600

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWERRERPLLQVALDFTTIPSAISVAVKALKADILEVGTPLIKSEGSKAVSAIAALGKP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCC
TLADTKTCDTGALEASIAFDAGADAMTVMAFSDDSVIKEAVEEAERRGKVVVADMMHLKD
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEHHHHHHHH
PVERAKRLKELGVRAVELHVGISQQRAYGVTAADLAALAERVRSLGLVVAVAGGITPETA
HHHHHHHHHHHCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHH
RAFVGKADVVVVGGYITKSPNPEKAVEELLKALGR
HHHHCCCCEEEECCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVWERRERPLLQVALDFTTIPSAISVAVKALKADILEVGTPLIKSEGSKAVSAIAALGKP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCC
TLADTKTCDTGALEASIAFDAGADAMTVMAFSDDSVIKEAVEEAERRGKVVVADMMHLKD
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEHHHHHHHH
PVERAKRLKELGVRAVELHVGISQQRAYGVTAADLAALAERVRSLGLVVAVAGGITPETA
HHHHHHHHHHHCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHH
RAFVGKADVVVVGGYITKSPNPEKAVEELLKALGR
HHHHCCCCEEEECCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA