Click here to switch to the map view.

The map label for this gene is yggV [C]

Identifier: 156936974

GI number: 156936974

Start: 159259

End: 159825

Strand: Direct

Name: yggV [C]

Synonym: Igni_0179

Alternate gene names: 156936974

Gene position: 159259-159825 (Clockwise)

Preceding gene: 156936973

Following gene: 156936975

Centisome position: 12.27

GC content: 56.97

Gene sequence:

>567_bases
ATGGTAAGCAAGAAGGTTTACTTCCTAACCTCTAACCCTCACAAGGCGAAGGAAGTTAGTGACGTGCTCAGCCAGTTCTC
GATCGAGGTGGTCCCTCTGAAGGGCGAGAAGTTGGAGATACAAGCGGACTCCGTGGAGGAGGTGGCGAGGTTCGCGGCGG
AGGAGGCCAAGAAGAGGTTCAAGGAGAGGCCGTTGCTCTTGGAGGACAGCGGGCTCTTCGTGGACGCTCTGAAGGGCTTC
CCGGGGCCGTACAGCAACTACGTTTATCGAACTCTGGGGTTGGAGGGGCTGTTGAAGCTCATGGAAGGGGTTGAGGACAG
GAGGGCGCGCTTCGTCTGCGCTGCTGCGTTAGTGAAGGAGGACGATAAGATCGTTATTGAGGTAGGAGAGGTTGAGGGCG
AAATAGCTTACGAGCCGAGGGGGGATAAGGGCTTCGGCTTCGACCCGATCTTCGTTCCCCTCGGCTACGAGAAGACCTTC
GCCGAGCTGGGGGAGGAGGTGAAGAAGAGGATTTCCCACAGGGCGAGGGCGTTCATGAAGATAGCTAAACACTTGTCCGG
GGAATAA

Upstream 100 bases:

>100_bases
GGAAGGGCTATTCTGAGTTCGGCGAGGCGGAGAAGATGAGGGAGCTGACCAAACAAATAGAGCTCTTGGGCCGCTACGTA
AAGGAGAGGAGGAAGACCGT

Downstream 100 bases:

>100_bases
CAGAGTGTCCCCGGCTCACCGCGGGCCCTCTGGCCCCCTTGCCGGGGAGCCGCCGGACTTAGGGACGGAGCCCTCTTGAA
ATGTTTTGAGGTCGCTCTGG

Product: RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRFKERPLLLEDSGLFVDALKGF
PGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKEDDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTF
AELGEEVKKRISHRARAFMKIAKHLSGE

Sequences:

>Translated_188_residues
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRFKERPLLLEDSGLFVDALKGF
PGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKEDDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTF
AELGEEVKKRISHRARAFMKIAKHLSGE
>Mature_188_residues
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRFKERPLLLEDSGLFVDALKGF
PGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKEDDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTF
AELGEEVKKRISHRARAFMKIAKHLSGE

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=188, Percent_Identity=35.6382978723404, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI31657144, Length=160, Percent_Identity=35, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1789324, Length=190, Percent_Identity=36.3157894736842, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17556833, Length=179, Percent_Identity=35.195530726257, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322529, Length=193, Percent_Identity=29.5336787564767, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19920712, Length=186, Percent_Identity=37.6344086021505, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_IGNH4 (A8A8W1)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001434770.1
- ProteinModelPortal:   A8A8W1
- SMR:   A8A8W1
- STRING:   A8A8W1
- GeneID:   5562338
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0179
- eggNOG:   arNOG10472
- HOGENOM:   HBG697237
- OMA:   FAYDSIF
- BioCyc:   IHOS453591:IGNI_0179-MONOMER
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21115; Mature: 21115

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRF
CCCCEEEEEECCCCHHHHHHHHHHHHCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
KERPLLLEDSGLFVDALKGFPGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKE
HHCCCEEECCCCHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHHCC
DDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTFAELGEEVKKRISHRARAFMK
CCEEEEEEECCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IAKHLSGE
HHHHHCCC
>Mature Secondary Structure
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRF
CCCCEEEEEECCCCHHHHHHHHHHHHCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
KERPLLLEDSGLFVDALKGFPGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKE
HHCCCEEECCCCHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHHCC
DDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTFAELGEEVKKRISHRARAFMK
CCEEEEEEECCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IAKHLSGE
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA